Risk factors for primary sclerosing cholangitis

Boonstra, Kirsten; Vries, Elisabeth M.G. de; Geloven, Nan van; Erpecum, Karel J. van; Spanier, Marcel; Poen, Alexander C.; Nieuwkerk, C.M. van; Witteman, Ben J.M.; Tuynman, Hans A.R.E.; Naber, A.H.J.; Kingma, Paul J.; Beuers, Ulrich; Ponsioen, Cyriel Y.

doi:10.1111/liv.12894

Cited by 27 publications

(22 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genome‐wide association studies suggest a polygenetic background with a defined, but limited role for autoimmunity . In view of the close association between IBD and PSC, gut‐derived inflammatory cells, toxins or microbial products have been postulated to play a role in the aetiology of PSC .…”

mentioning

confidence: 99%

Elevated interleukin‐8 in bile of patients with primary sclerosing cholangitis

Zweers

Shiryaev

Komuta

et al. 2016

Liver International

Self Cite

View full text Add to dashboard Cite

Background & Aims To better understand the pathogenesis of primary sclerosing cholangitis, anti‐ and pro‐inflammatory factors were studied in bile. Methods Ductal bile of PSC patients (n = 36) and controls (n = 20) was collected by endoscopic retrograde cholangiography. Gallbladder bile was collected at liver transplantation. Bile samples were analysed for cytokines, FGF19 and biliary lipids. Hepatobiliary tissues of PSC and non‐PSC patients (n = 8–11 per patient group) were collected at transplantation and were analysed for IL8 and FGF19 mRNA expression and IL8 localization. The effect of IL8 on proliferation of primary human cholangiocytes and expression of pro‐fibrotic genes was studied. Results In PSC patients, median IL8 in ductal bile was 6.6 ng/ml vs. 0.24 ng/ml in controls. Median IL8 in gallbladder bile was 7.6 ng/ml in PSC vs. 2.2 and 0.3 ng/ml in two control groups. IL8 mRNA in PSC gallbladder was increased and bile ducts stained positive for IL8. In vitro, IL8 induced proliferation of primary human cholangiocytes and increased the expression of pro‐fibrotic genes. Conclusion Elevation of IL8 in bile of PSC patients, collected at different stages of disease, indicates an ongoing inflammatory stimulus that drives IL8 production. This challenges the idea that advanced PSC is a burned‐out disease, and calls for reconsideration of anti‐inflammatory therapy in PSC.

show abstract

mentioning

confidence: 99%

Elevated interleukin‐8 in bile of patients with primary sclerosing cholangitis

Zweers

Shiryaev

Komuta

et al. 2016

Liver International

Self Cite

View full text Add to dashboard Cite

show abstract

“…Still, only four (10%) patients were lost to follow up, meaning that complications were captured in most patients during the study period. We were unable to capture tobacco use on our patients, which is a known protective factor for PSC …”

Section: Discussionmentioning

confidence: 99%

Long‐term outcomes of primary sclerosing cholangitis: an Australian non‐transplant tertiary hospital perspective

Freeman

Majeed

Kemp

et al. 2019

Internal Medicine Journal

View full text Add to dashboard Cite

show abstract

“…On the other hand, PSC is a progressive cholestatic liver disease, which is strongly associated with inflammatory bowel disease. A case-control study in the Netherlands has demonstrated that smoking has a protective effect for developing PSC [1]. In terms of AIH, it is mentioned that alcohol drinking and living in a childhood home with wood heating are protective factors against the development of AIH [2].…”

Section: Discussionmentioning

confidence: 99%

“…In Europe, AILD represent a major indication for liver transplantation. As complex disorders, AILD develop from the interactions between a variety of genetic and environmental factors [1–3]. Until now, the pathogenesis of PBC, PSC, AIH or IgG4 related cholangitis has not been fully elaborated.…”

Section: Introductionmentioning

confidence: 99%

National incidence of autoimmune liver diseases and its relationship with the human development index

et al. 2016

View full text Add to dashboard Cite

ObjectivePrimary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) and immunoglobulin G4 related cholangitis represent the major autoimmune liver diseases (AILD). However, the relationship between AILD incidence and socioeconomic development levels is yet to be explored.ResultsA total of 43 studies were included. There was a positive but not significant correlation between the PBC incidence and HDI on a global level (r=0.348, P=0.082). However, in Europe, a significantly positive correlation existed between the PBC incidence and HDI (r=0.455, P=0.044). No statistical correlation between PSC incidence and HDI was observed (r=0.116, P=0.706). The incidence of AIH revealed a positive correlation with the national HDI both globally (r=0.638, P=0.014) and in Europe (r=0.644, P=0.045). Moreover, the PBC incidence demonstrated a positive correlation with the health index (r=0.422, P=0.036), but a negative correlation with the education index (r= −0.650, P<0.01). Moreover, the income index presented a positive correlation with both the PSC incidence (r=0.599, P=0.031) and the AIH incidence (r=0.649, P=0.012).MethodsPubMed was searched to identify relevant epidemiological studies on AILD. The human development index (HDI) was applied as an indicator for socioeconomic development. HDI data were obtained and calculated based on the 2014 Human Development Report. Pearson coefficient and linear regression analysis were conducted to estimate the correlation between incidence and HDI.ConclusionsThere is positive association between the national incidence of AILD and the socioeconomic status, as measured by HDI. In less-developed countries, the incidence of AILD, especially PBC and AIH, might be less common.

show abstract

Risk factors for primary sclerosing cholangitis

Abstract: In this large population-based case-control study we confirm that smoking is associated with a lower risk of developing PSC, independent of its protective effect for developing UC. Appendectomy is not associated with the risk of developing PSC.

Cited by 27 publications

References 36 publications

Elevated interleukin‐8 in bile of patients with primary sclerosing cholangitis

Elevated interleukin‐8 in bile of patients with primary sclerosing cholangitis

Long‐term outcomes of primary sclerosing cholangitis: an Australian non‐transplant tertiary hospital perspective

National incidence of autoimmune liver diseases and its relationship with the human development index

Contact Info

Product

Resources

About