Risk factors for progression of and treatment options for NAFLD in children

Hartmann, Phillipp; Schnabl, Bernd

doi:10.1002/cld.685

Cited by 21 publications

(15 citation statements)

References 11 publications

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“…Covariates were selected as potential confounders because they were reported to be associated with NAFLD or the P-value <0.1 on the basis of the statistical consideration. Age, BMI, gender, hyperlipidemia hypertension, diabetes, smoking, passive smoking, drinking, education, and income were adjusted in the final models [18][19][20][21]. Two-sided P-values of <0.05 were considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Associations between Phase Angle Values Obtained by Bioelectrical Impedance Analysis and Nonalcoholic Fatty Liver Disease in an Overweight Population

Chen

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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Objective. There is a limited diagnosis of nonalcoholic fatty liver disease (NAFLD). Thus, the noninvasive assessments are worth exploring. We determined the associations of phase angles (PhAs) obtained from bioelectric impedance analysis (BIA) with the risk of NAFLD in an overweight population. Methods. A study involving 953 overweight participants was conducted in Wuhan city, China. The associations between PhAs (right arm, left arm, body trunk, right leg, left leg, and whole body) and the risk of NAFLD were conducted using multivariate logistic regression analyses. The associations of PhAs with the controlled attenuation parameter (CAP), a noninvasive assessment of liver steatosis and fibrosis, were also evaluated by both linear and logistic regression analyses. Results. The PhA values of the whole body, trunk, and legs were significantly lower (P<0.05) in the NAFLD group than the non-NAFLD group. After adjustment for BMI, gender, education, income/year, hyperlipidemia, hypertension, diabetes, smoking, passive smoking, and drinking, significant associations of PhA values of the right leg, left leg, and whole body with the risk of NAFLD were observed. In addition, the PhA of the right leg, left leg, and whole body were significantly related to the CAP values. Further stratified analyses indicated that these associations were significant in the participants with BMI <30, but not in the participants with BMI ≥30. Conclusions. PhAs might be effective indicators in the management of NAFLD among overweight people.

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Section: Discussionmentioning

confidence: 99%

Associations between Phase Angle Values Obtained by Bioelectrical Impedance Analysis and Nonalcoholic Fatty Liver Disease in an Overweight Population

Chen

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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“… 7 In addition, the prevalence of NAFLD also showed an increasing trend among young children. 8 Therefore, NAFLD has become a worldwide public health problem. Currently, the drugs used in the clinical treatment of NAFLD, such as membrane insulin sensitizers, antioxidants, biological agents, weight-loss drugs, anti-inflammatory and liver-protecting drugs, are beneficial to the relief of symptoms, but cannot completely reverse NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice

Li¹,

Yang²,

Yang³

et al. 2021

JIR

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Background: Ginkgo biloba extract 50 (GBE50) has a variety of pharmacological functions such as anti-inflammatory, antioxidant and maintenance of glucose and lipid metabolism homeostasis. However, the therapeutic effects and mechanisms of GBE50 on non-alcoholic fatty liver disease (NAFLD) remain unknown. Therefore, in this study, we evaluated the therapeutic effects of GBE50 in NAFLD by using a high-fat diet (HFD) mice model. Methods: C57BL/6J mice were fed a HFD diet for 15 weeks and were given respectively 25, 50, and 100 mg/kg GBE50 daily by gavage from 3 to 15 weeks. After the administration, blood samples and liver tissues were collected for biochemical detection, histological measurement, immunohistochemistry and Western blot, respectively. Results: We found that GBE50 treatment could ameliorate insulin resistance (IR), glucose intolerance, lipid accumulation, hepatic steatosis and liver injury in HFD-fed mice. Further mechanism exploration discovered that the hepatoprotective effects of GBE50 on NAFLD may be related to the strengthening of IRS-1 signal activation and the weakening of NF-κB, Akt and endoplasmic reticulum stress signals activation. Conclusion: GBE50 is a potentially powerful therapeutic agent for the treatment of NAFLD.

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“…For example, mutations of PNPLA3I148 M and TM6SF2 E167K affect the remodelling of lipid droplet and the secretion of lipid in liver cells, which may increase the risk of liver disease in children under 18; [ 13 – 15 ] The Mttp variant rs2306986 is an independent risk factor for NAFLD onset in children aged 6 to 18 years. [ 16 ] It is generally believed that the intestinal liver axis may enhance the interaction between intestinal bacteria-bacterial products and liver receptors, thereby promoting oxidative stress, insulin resistance, liver inflammation and fibrosis. Studies [ 17 ] suggest fatty liver.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy and safety of traditional Chinese patent medicine for NAFLD in childhood or adolescence

et al. 2021

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Background: Nonalcoholic fatty liver disease is a common reason for chronic liver disease in children and adults. The increasing incidence of the disease has become one of the most critical public health problems in the 21st century, closely related to genetic and environmental factors. So far, apart from changing lifestyle and diet, modern medicine still lacks effective treatment measures. Chinese patent medicine has the advantages of apparent curative effect, overall regulation and fewer side effects. However, there is a lack of research on the simultaneous comparison of various Chinese patent medicines. Therefore, we used a reticular meta-analysis to indirectly compare the efficacy and safety of different oral Chinese patent medicines through standard reference. Method: We will conduct a comprehensive and systematic search of Chinese and English databases from the beginning to December 2020. All randomized controlled trials (RCTs) of oral Chinese patent medicine for NAFLD in children will be searched. The 2 researchers then independently filter the retrieved literature, extract the data according to the data extraction table and assess the risk of bias. We will perform a pair of meta-analyses and a Bayesian network meta-analysis. STATA and Win BUGS software will be used for data analysis. Results: This study will thoroughly compare and analyze the differences in the efficacy of all kinds of TCPM in NAFLD treatment in childhood or adolescence. Conclusion: This study will provide reference and evidence support for clinical drug selection optimization. Ethics and dissemination: This study does not require ethical approval. INPLASY registration number: 2020120068.

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Risk factors for progression of and treatment options for NAFLD in children

Abstract: http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/11-1-reading-hartmann.html a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/11-1-interview-hartmann.html the interview with the author

Cited by 21 publications

References 11 publications

Associations between Phase Angle Values Obtained by Bioelectrical Impedance Analysis and Nonalcoholic Fatty Liver Disease in an Overweight Population

Associations between Phase Angle Values Obtained by Bioelectrical Impedance Analysis and Nonalcoholic Fatty Liver Disease in an Overweight Population

Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice

Comparative efficacy and safety of traditional Chinese patent medicine for NAFLD in childhood or adolescence

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