Risk factors for sudden deafness: a case-control study

Nakashima, Tsutomu; Tanabe, Tada-aki; Yanagita, Noriyuki; Wakai, Kenji; Ohno, Yoshiyuki

doi:10.1016/s0385-8146(96)00024-7

Cited by 51 publications

(48 citation statements)

References 13 publications

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“…0.001). In our study, treated hypertension, diabetes, and hyperlipidemia were not associated with the risk of ISSHL; this is in accordance with other case-control studies, also based on the interview of the subjects [Nakashima et al, 1997;Rudack et al, 2006]. The size of the cohort and the population-based data set (data collected from Taiwan's National Health Insurance program in the study published by Lin et al [2008]) could account for these controversial results.…”

Section: Cardiovascular and Thromboembolic Risk Factorssupporting

confidence: 89%

“…The size of the cohort and the population-based data set (data collected from Taiwan's National Health Insurance program in the study published by Lin et al [2008]) could account for these controversial results. Smoking is an important risk factor of cardiovascular disease, but the prevalence of smokers was similar among ISSHL patients and controls in our study, and in the literature [Nakashima et al, 1997;Marcucci et al, 2005]. Only Rudack et al [2006] found that the frequency of current smokers was higher in patients compared to controls (80/142 vs. 18/84, p !…”

Section: Cardiovascular and Thromboembolic Risk Factorssupporting

confidence: 71%

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Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Mosnier

Stépanian²,

Baron³

et al. 2010

Audiol Neurotol

139

126

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Objective: The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSHL) remains unknown, but vascular involvement is one of the main hypotheses. The main objective of this study was to investigate the association between ISSHL and cardiovascular and thromboembolic risk factors. Study Design: Multicentric case-control study. Methods: Ninety-six Caucasian patients with ISSHL and 179 sex- and age-matched controls were included. Patients were evaluated on the day of the inclusion and 1 week, 3 weeks and 3 months later. Clinical information concerning personal and familial cardiovascular and thromboembolic risk factors and concerning the ISSHL was collected. Blood samples were collected for genetic analysis of factor V Leiden and G20210A polymorphism in the factor II gene. The severity of the hearing loss was classified as mild (21–40 dB), moderate (41–70 dB), severe (71–90 dB) and profound or total (>90 dB). Hearing improvement was calculated as a relative improvement of hearing thresholds using the contralateral ear as baseline. Results: Systolic blood pressure was higher in patients (130 ± 1.7 mm Hg) than in controls (124 ± 1.1 mm Hg, p = 0.003). The personal/familial history of cardiovascular events was also more prevalent in patients (p = 0.023 and p = 0.014, respectively), whereas no difference was found in the prevalence of personal cardiovascular risk factors (hypertension, diabetes mellitus, hyperlipidemia, smoking habits). There was no correlation between the audiogram type, the hearing outcome and the presence of cardiovascular risk factors. No significant difference was observed in the personal/familial history or in the presence of thromboembolic risk factors. The prothrombin and factor V mutations were uncommon in both patients and controls. The final hearing threshold was only correlated with the severity of the initial hearing loss (p < 0.001), but not influenced by the presence of vertigo, audiogram type, time elapsed from onset of ISSHL to hospitalization or failure of a previous oral therapy. Hearing stabilization was obtained at 21 days in 92% of patients. Conclusion: These results support the theory of vascular involvement as the etiology of some cases of ISSHL. The sole predictive factor of poor final hearing is the severity of the initial hearing loss.

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Section: Cardiovascular and Thromboembolic Risk Factorssupporting

confidence: 89%

Section: Cardiovascular and Thromboembolic Risk Factorssupporting

confidence: 71%

Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Mosnier

Stépanian²,

Baron³

et al. 2010

Audiol Neurotol

139

126

View full text Add to dashboard Cite

show abstract

“…Possible causes of SSNHL may include viral or bacterial infection, circulatory disturbance in the area of the anterior inferior cerebellar artery, acoustic tumor, perilymphatic fistula [4], environment [5], diet [6] or weather [7]. SSNHL is also occasionally preceded by a common cold or upper respiratory tract infection, as reported in patients with vestibular neuronitis [8] or Ménière’s disease [7].…”

Section: Introductionmentioning

confidence: 99%

Sudden Sensorineural Hearing Loss: Evidence from Taiwan

2006

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Objective:This study uses 5-year population data to determine the incidence rate of sudden sensorineural hearing loss (SSNHL) in Taiwan, taking into consideration the age and gender of patients, as well as seasonal variations. Study Design:A retrospective cross-sectional study. Method: The data used is from the Taiwan National Health Insurance Research Database covering the period from 1998 to 2002. A total of 9,267 sample patients were identified from the database by a principal diagnosis of unspecified sudden hearing loss (ICD-9-CM code 3882). The autoregressive integrated moving average (ARIMA) method was also carried out in order to identify any variations in the monthly incidence rates of SSNHL. Results:We find that for the period under examination, gender-specific incidence rates per 100,000 of the population were 8.85 for males, and 7.79 for females, and that there was an increase in age-specific SSNHL incidence with age. The ARIMA test for seasonality was found to be significant for the whole sample. Of all the seasons in Taiwan, the highest SSNHL incidence rates were found in autumn. Conclusions: Our finding of significant variations in the monthly incidence of SSNHL provides valuable information for otolaryngologists and public health officials, creating an awareness of periods of a potential increased risk of SSNHL.

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“…2005; Nakashima et al, 1997;Nakamura et al, 2001]. However, despite their recognition of a number of possible triggering factors proposed for SSNHL, very few of the empirical studies have placed any emphasis on an investigation into the existence, or otherwise, of an association between the weather and the onset of SSNHL; therefore, the relationship between these two factors has yet to be fully examined.…”

mentioning

confidence: 99%

The Effects of Weather on the Incidence of Sudden Sensorineural Hearing Loss: A 5-Year Population-Based Study

Lin

Lee²,

Chao

et al. 2006

Audiol Neurotol

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Objective:This study utilizes 5-year population data to examine the association between weather conditions and the incidence of sudden sensorineural hearing loss (SSNHL) in Taiwan with a specific focus on ambient temperature, relative humidity, atmospheric pressure, rainfall and total hours of sunshine. Method: The data, covering the period from 1998 to 2002, is sourced from the Taiwan National Health Insurance Research Database (NHIRD), with a total of 8712 first-time admissions being identified from the database by a principal diagnosis of unspecified sudden hearing loss (ICD-9-CM code 3882). After controlling for time trend effects, this study adopted the autoregressive integrated moving average regression method as a means of evaluating the effects of climatic and monthly factors on SSNHL incidence rates. Results:Although significant associations were found between ambient temperature, relative humidity and the SSNHL incidence rates for the total population, after adjusting for seasonality, months and trends, the significant relationship between SSNHL incidence rates and the climatic parameters disappeared. Conclusions: This study has demonstrated that after adjusting for seasonality, months and trends, there is no significant relationship between monthly SSNHL incidence rates and weather conditions. Therefore, the theory that weather is a triggering factor in SSNHL pathogenesis is not supported by this study.

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Risk factors for sudden deafness: a case-control study

Cited by 51 publications

References 13 publications

Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Sudden Sensorineural Hearing Loss: Evidence from Taiwan

The Effects of Weather on the Incidence of Sudden Sensorineural Hearing Loss: A 5-Year Population-Based Study

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