Risk factors for the development of non-response to first-line treatment for tuberculosis in southern Vietnam

Keane, Vincent; Klerk, Nicholas de; Krieng, T; Hammond, G. Denman; Musk, A.W.

doi:10.1093/ije/26.5.1115

Cited by 13 publications

(8 citation statements)

References 12 publications

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“…There may be other socio-cultural characteristics among our population that blunted any differences. , weight loss 10,11 and HIV 12 seropositivity were not significant in our study.…”

Section: Discussioncontrasting

confidence: 69%

“…13 It is noteworthy that Keane et al who used a treatment regimen similar to ours did not find high bacillary load at start of treatment a predictor of treatment failure. 11 Presence of cavities on the chest radiograph and extensive radiological involvement were not found to be significantly associated with treatment failure at multivariate analysis contrary to what was demonstrated by Qingsong et al (OR 1.5, p=<0.001) 14 This was probably due to inadequate sample size. Poor adherence to treatment was also a predictor of treatment failure in our study.…”

Section: Discussionmentioning

confidence: 60%

“…Studies done in other settings show that these predictors include social, radiological, laboratory and treatment related factors. 4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] No study had been done in our setting to identify these predictors and we did a case control study to identify them.…”

mentioning

confidence: 99%

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Predictors of treatment failure among pulmonary tuberculosis patients in Mulago hospital, Uganda

Namukwaya¹,

Fn²,

Mulekya³

et al. 2011

Af Hlth Sci

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“…There may be other socio-cultural characteristics among our population that blunted any differences. , weight loss 10,11 and HIV 12 seropositivity were not significant in our study.…”

Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 60%

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Predictors of treatment failure among pulmonary tuberculosis patients in Mulago hospital, Uganda

Namukwaya¹,

Fn²,

Mulekya³

et al. 2011

Af Hlth Sci

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“…In this way a larger proportion of patients will be correctly treated with the drug that is provided free of costs by the ministry of health while avoiding the use of second line drugs that have adverse side effects and are more expensive [17], [18]. Similar approaches to determine prognostic scores of treatment failure have been proposed for other diseases such as tuberculosis [19]. Clinical scores were also developed to predict fatal outcome in patients with visceral leishmaniasis [20], [21].…”

Section: Discussionmentioning

confidence: 99%

Prediction Score for Antimony Treatment Failure in Patients with Ulcerative Leishmaniasis Lesions

et al. 2012

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Background Increased rates for failure in leishmaniasis antimony treatment have been recently recognized worldwide. Although several risk factors have been identified there is no clinical score to predict antimony therapy failure of cutaneous leishmaniasis. Methods A case control study was conducted in Peru from 2001 to 2004. 171 patients were treated with pentavalent antimony and followed up to at least 6 months to determine cure or failure. Only patients with ulcerative cutaneous leishmaniasis (N = 87) were considered for data analysis. Epidemiological, demographical, clinical and laboratory data were analyzed to identify risk factors for treatment failure. Two prognostic scores for antimonial treatment failure were tested for sensitivity and specificity to predict antimony therapy failure by comparison with treatment outcome. Results Among 87 antimony-treated patients, 18 (21%) failed the treatment and 69 (79%) were cured. A novel risk factor for treatment failure was identified: presence of concomitant distant lesions. Patients presenting concomitant-distant lesions showed a 30.5-fold increase in the risk of treatment failure compared to other patients. The best prognostic score for antimonial treatment failure showed a sensitivity of 77.78% and specificity of 95.52% to predict antimony therapy failure. Conclusions A prognostic score including a novel risk factor was able to predict antimonial treatment failure in cutaneous leishmaniasis with high specificity and sensitivity. This prognostic score presents practical advantages as it relies on clinical and epidemiological characteristics, easily obtained by physicians or health workers, and makes it a promising clinical tool that needs to be validated before their use for developing countries.

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“…We searched for articles describing radiological signs associated pulmonary MDR-TB (as compared to DS-TB), particularly we looked for radiological signs which may offer differentiation between pulmonary MDR-TB and DS-TB. It has already been known that cavitary lesion can be seen in both DS-TB and MDR-TB, and with higher prevalence in MDR-TB (12)(13)(14)(15)(16). However, cavitary lesion alone does not offer differential diagnosis of MDR-TB, thus articles merely reported the differences of cavitary lesion prevalence in DS-TB and MDR-TB were not analyzed in this review.…”

Section: Methodsmentioning

confidence: 99%

Radiological signs associated with pulmonary multi-drug resistant tuberculosis: an analysis of published evidences

Wáng

Chung

Skrahin

et al. 2018

Quant. Imaging Med. Surg.

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Risk factors for the development of non-response to first-line treatment for tuberculosis in southern Vietnam

Cited by 13 publications

References 12 publications

Predictors of treatment failure among pulmonary tuberculosis patients in Mulago hospital, Uganda

Predictors of treatment failure among pulmonary tuberculosis patients in Mulago hospital, Uganda

Prediction Score for Antimony Treatment Failure in Patients with Ulcerative Leishmaniasis Lesions

Radiological signs associated with pulmonary multi-drug resistant tuberculosis: an analysis of published evidences

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