Risk factors for the development of premature ventricular complex-induced cardiomyopathy: a systematic review and meta-analysis

Lavallaz, J Du Fay De; Mézier, Julien; Mertz, Lara; Mannhart, Diego; Serban, Teodor; Knecht, Sven; Abid, Qurrat‐ul‐ain; Nguyen, Tai Van; Kühne, Michael; Sticherling, Christian; Huang, Henry; Gold, Michael R.; Badertscher, Patrick

doi:10.1007/s10840-022-01421-8

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…For PVC-induced cardiomyopathy, the identification of PVC burden as a primary risk factor echoes current understanding, 35 yet the survey indicates variability in the assessment of right ventricular function, suggesting an area where guidelines could provide clarity. 36…”

Section: Discussionmentioning

confidence: 98%

Definition and management of arrhythmia-induced cardiomyopathy: findings from the European Heart Rhythm Association survey

Serban,

Badertscher,

du Fay de Lavallaz

et al. 2024

Europace

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Background Arrhythmia-induced Cardiomyopathy (AiCM) represents a subtype of acute heart failure (HF) in the context of sustained arrhythmia. Clear definitions and management recommendations for AiCM are lacking. Purpose The European Heart Rhythm Association Scientific Initiatives Committee (EHRA SIC) conducted a survey to explore the current definitions and management of patients with AiCM among European and non-European electrophysiologists. Methods A 25-item online questionnaire was developed and distributed among EP specialists on the EHRA SIC website and on social media between September 4th and October 5th 2023. Results Of the 206 respondents, 16% were female and 61% were between 30-49 years old. Most of the respondents were EP-Specialists (81%) working at University Hospitals (47%). While most participants (67%) agreed that AiCM should be defined as a left ventricular ejection fraction (LVEF) impairment after new onset of an arrhythmia, only 35% identified a specific LVEF drop to diagnose AiCM with a wide range of values (5-20% LVEF drop). Most respondents considered all available therapies: catheter ablation(93%), electrical cardioversion(83%), antiarrhythmic drugs (76%) and adjuvant HF treatment(76%). 83% of respondents indicated that adjuvant HF treatment should be started at first HF diagnosis prior to antiarrhythmic treatment and 84% agreed it should be stopped within six months after LVEF normalization. Responses for the optimal time point for the first LVEF reassessment during follow-up varied markedly (1 day-6 months after antiarrhythmic treatment). Conclusion This EHRA Survey reveals varying practices regarding AiCM among physicians, highlighting a lack of consensus and heterogenous care of these patients.

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Section: Discussionmentioning

confidence: 98%

Definition and management of arrhythmia-induced cardiomyopathy: findings from the European Heart Rhythm Association survey

Serban,

Badertscher,

du Fay de Lavallaz

et al. 2024

Europace

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Premature ventricular complexes: Assessing burden density in a large national cohort to better define optimal ECG monitoring duration

Krumerman,

Di Biase,

Gerstenfeld

et al. 2024

Heart Rhythm

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Monomorphic premature ventricular contractions in patients without cardiac structural changes: clinical and prognostic significance and evaluation of therapy effectiveness (clinical and experimental study)

Olesin,

Konstantinova,

Tyuteleva

et al. 2024

Russ J Cardiol

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Aim. To determine the individualized choice of therapy for monomorphic premature ventricular contractions (PVCs) in patients without structural cardiac changes by assessing the predictors of arrhythmogenic cardiomyopathy (ACM) and the clinical and prognostic significance of its course.Material and methods. Experimental study. Animals were used to model PVCs by the mechanism of early post-depolarization (EPD) (aconitine), re-entry (peroxide or H2O2 arrhythmia). In addition to the generally accepted parameters, the following ACMs were analyzed during electrocardiography (ECG): pre-ectopic interval, its variability, maximum index of internal deviation of PVCs, the QRS complex of PVC (QRSpvc), QRS of sinus rhythm (QRSsr), their ratio (QRSpvc/QRSsr), etc. Clinical study. A total of 343 patients with class IV-V PVCs aged 16 to 34 years were observed (B. Rayn, 1984). The same parameters were determined by ECG as in experimental arrhythmias. The follow-up duration was up to 10 years. The end point was the detection or absence of cardiovascular pathology.Results. Experimental study. When modeling ventricular arrhythmias using the EPD mechanism, early (R/T) monotopic PVCs were recorded, and re-entry — early and late monomorphic PVCs. ACM predictors were recorded only when modeling arrhythmia by the re-entry mechanism. Clinical study. In patients without structural cardiac changes, early (R/T) monotopic PVC highly correlated with ventricular ectopy induced by the EPD mechanism (aconitine) (r=0,92). These patients did not have cardiovascular diseases, and the most effective antiarrhythmic drugs for eliminating ventricular ectopy were class I drugs. In patients without structural cardiac changes, early and late monomorphic PVCs highly correlated with experimental ventricular ectopy caused by the re-entry mechanism (H2O2 arrhythmia). In these patients, on average, 7,2±0,5 years after inclusion in the study, various clinical forms of coronary artery disease were detected, and the positive clinical effect of PVC treatment was achieved mainly with the use of class III antiarrhythmic drugs.Conclusion. In patients with early monotopic ventricular ectopia, without detection of ACM predictors, the most effective were class I antiarrhythmic drugs. In other patients with early and late monomorphic ventricular ectopia and detected ACM predictors, class III agents were found to be effective.

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Risk factors for the development of premature ventricular complex-induced cardiomyopathy: a systematic review and meta-analysis

Cited by 4 publications

References 54 publications

Definition and management of arrhythmia-induced cardiomyopathy: findings from the European Heart Rhythm Association survey

Definition and management of arrhythmia-induced cardiomyopathy: findings from the European Heart Rhythm Association survey

Premature ventricular complexes: Assessing burden density in a large national cohort to better define optimal ECG monitoring duration

Monomorphic premature ventricular contractions in patients without cardiac structural changes: clinical and prognostic significance and evaluation of therapy effectiveness (clinical and experimental study)

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