Risk factors for ventricular septal defect in finland

Tikkanen, J.; Heinonen, Olli P.

doi:10.1016/s0033-3506(05)80283-5

Cited by 64 publications

(45 citation statements)

References 24 publications

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“…152 In a casecontrol study of 90 patients with conotruncal abnormalities and 150 with VSDs born in Finland between 1982 and 1983, the effect of maternal alcohol use was compared with 756 controls. 119 Although more mothers of infants with conotruncal malformations consumed any alcohol, consumed alcohol regularly every week, and consumed Ͼ1 drink per occasion, these results did not reach statistical significance. Maternal alcohol consumption during the first trimester of pregnancy was more common among the mothers of infants with VSDs (47%) than among those of controls (38%; PϽ0.05).…”

Section: Alcoholmentioning

confidence: 92%

“…No association with maternal use of diazepam during the first trimester of pregnancy was seen in case-control studies of 150 children with VSDs. 91,119 The frequencies of congenital anomalies were not significantly increased among infants of women occasionally treated with amobarbital (FDA category D) as a hypnotic. However, the frequency of cardiac malformations was increased (RR, 2.6; 95% CI, 1.0 to 5.2).…”

Section: Art Dyesmentioning

confidence: 98%

“…Maternal alcohol consumption during the first trimester of pregnancy was more common among the mothers of infants with VSDs (47%) than among those of controls (38%; PϽ0.05). 119 A case-control study of conotruncal defects in Atlanta showed no association with maternal reports of alcohol consumption (OR, 0.72; 95% CI, 0.49 to 1.06) or "binge" drinking (OR, 0.44; 95% CI, 0.13 to 1.46). 36 A more recent case-control study that examined the risk of congenital anomalies with different sporadic and daily doses of alcohol consumption in Spain reported an increased risk of congenital heart defects as a group only with the highest level of maternal consumption of alcohol per day (ie, Ͼ92 g/d).…”

Section: Alcoholmentioning

confidence: 98%

“…Reports of exposure to degreasing or other solvents have been associated with an increased risk of hypoplastic left heart syndrome, coarctation of the aorta, pulmonic stenosis, transposition of the great arteries with intact ventricular septum, tetralogy of Fallot, total anomalous pulmonary venous return, nonchromosomal atrioventricular septal defects, and Ebstein's anomaly. 6 Maternal reports of occupational exposure to organic solvents have been associated with an increased risk of VSDs 119,175 ; dyes, lacquers, and paints with conotruncal malformations 150 ; and mineral oil products with coarctation of the aorta. 176 Herbicides, Pesticides, and Rodenticides A study suggesting an association of maternal employment in the agricultural industry with an increased risk of conotruncal defects 36 suggested a possible association with chemicals used in agriculture.…”

Section: Organic Solventsmentioning

confidence: 99%

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Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Jenkins¹,

Correa²,

Feinstein³

et al. 2007

Circulation

712

336

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Abstract-Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although relatively less information has been available on noninherited modifiable factors that may have an adverse effect on the fetal heart, there is a growing body of epidemiological literature on this topic. This statement summarizes the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects. Information is summarized for periconceptional multivitamin or folic acid intake, which may reduce the risk of cardiac disease in the fetus, and for additional types of potential exposures that may increase the risk, including maternal illnesses, maternal therapeutic and nontherapeutic drug exposures, environmental exposures, and paternal exposures. Information is highlighted regarding definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis. Caveats regarding interpretation of possible exposure-outcome relationships from case-control studies are given because this type of study has provided most of the available information. Guidelines for prospective parents that could reduce the likelihood that their child will have a major cardiac malformation are given. Issues related to pregnancy monitoring are discussed. Knowledge gaps and future sources of new information on risk factors are described.

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Section: Alcoholmentioning

confidence: 92%

Section: Art Dyesmentioning

confidence: 98%

Section: Alcoholmentioning

confidence: 98%

Section: Organic Solventsmentioning

confidence: 99%

See 2 more Smart Citations

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Jenkins¹,

Correa²,

Feinstein³

et al. 2007

Circulation

712

336

View full text Add to dashboard Cite

show abstract

“…It is estimated that in 4% of cases a chromosomal or genetic defect exists (1,8). A role of environmental and chemical factors has also been suggested (9). In addition, a review of the literature shows that various maternal diseases, e.g., diabetes mellitus, infections, fever, as well as the treatment applied, may induce VSDs (1-3,9,10).…”

Section: Introductionmentioning

confidence: 99%

Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors

Burdan

Szumiło

Dudka

et al. 2006

Braz J Med Biol Res

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Ventricular septal defects (VSDs) are common congenital abnormalities which have been reported to be associated with maternal fever and various environmental factors. The aim of the present study was to evaluate the effect of prenatal exposure to cyclooxygenase (COX) inhibitors on heart defects. A retrospective statistical analysis was performed using data collected in our laboratory during various teratological studies carried out on albino CRL:(WI)WUBR Wistar strain rats from 1997 to 2004. The observations were compared with concurrent and historic control data, as well as findings from other developmental toxicological studies with selective and nonselective COX-2 inhibitors. Despite the lack of significant differences in the frequency of VSDs between drug-exposed and control groups, statistical analysis by the two-sided Mantel-Haenszel test and historical control data showed a higher incidence of heart defects in offspring exposed to nonselective COX inhibitors (30.06/10,000). Unlike other specific inhibitors, aspirin (46.26/10,000) and ibuprofen (106.95/ 10,000) significantly increased the incidence of the VSD when compared with various control groups (5. 38-19.72/10,000). No significant differences in length or weight were detected between fetuses exposed to COX inhibitors and born with VSD and non-malformed offsprings. However, a statistically significant increase of fetal body length and decrease of body mass index were found in fetuses exposed to COX inhibitors when compared with untreated control. We conclude that prenatal exposure to COX inhibitors, especially aspirin and ibuprofen, increased the incidence of VSDs in rat offspring but was not related to fetal growth retardation.

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Geographic and Occupational Risk Factors for Ventricular Septal Defects

Batra¹,

Heike²,

Phillips³

et al. 2007

Arch Pediatr Adolesc Med

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Objective: Ventricular septal defect (VSD) is currently the most common congenital cardiac malformation in the United States, but little is known about its etiology. The objective of this study was to address the hypothesis that parents' residence in eastern Washington, a region heavily dominated by the agricultural industry, and employment in agriculturally related occupations can influence the presence of a VSD in their offspring.Design: Population-based case-control study. Patients: Children aged 0 to 2 years diagnosed as having a VSD (n=3489), and other infants selected at random as control subjects (n = 13 290). Results: The risk of VSD was greater for infants whose mothers resided in eastern Washington (odds ratio, 1.30; 95% confidence interval, 1.03-1.65). The risk of VSD with other cardiac malformations (n=1205) exhibited a stronger geographic association than did isolated VSD (n=2284). Analyses restricted to eastern Washington did not reveal a clear relationship between the risk of VSD and an increasing proportion of agricultural land in the mother's county of residence. Parental occupation in agriculture was not associated with the presence of VSD.Conclusion: Although these findings suggest regional variation in Washington State in the occurrence of VSD, the basis for this variation remains to be determined. Med. 2007;161:89-95 Arch Pediatr Adolesc

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Risk factors for ventricular septal defect in finland

Cited by 64 publications

References 24 publications

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors

Geographic and Occupational Risk Factors for Ventricular Septal Defects

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