Risk factors of gestational diabetes mellitus in Wuhan city of China--a case control study

Abstract

Objective: To explore the main risk factors of gestational diabetes mellitus in Wuhan, China.Methods: 206 women with gestational diabetes mellitus who were diagnosed in Hubei Maternal and Child Health Hospital between January 2014 and December 2015 were selected as case group. Meanwhile, 286 healthy pregnant women, who were delivered at the same time, were selected as control group. Maternal age, occupation, race/ethnicity, gestation status, and family history, etc. were obtained from the face-to-face interviews as well as their medical records. Univariate logistic regression analysis and multivariate logistic regression analysis were conducted to explore the risk factors. Results:The factors included into multivariate logistic regression model were maternal age, menarche age, history of menstrual cycle disorder, spontaneous abortion frequency, maternal history of diabetes, and paternal history of diabetes. The Odds Ratios (95%CI) were 1.50 (1.14～2.04), 0. 36 (0.16～0.84), 3.85 (1. 59～9. 36), 3.00 (1.56～5.77), 3.89 (1.15～13.17) and 6.54 (2.42～17.69), respectively. Conclusion:The risk factors of gestational diabetes mellitus were advanced maternal age, history of menstrual cycle disorder, spontaneous abortion frequency, maternal history of diabetes, and paternal history of diabetes, while advanced menarche age was a protective factor for gestational diabetes mellitus.

Comparison of Maternal and Fetal Outcomes in Parturients With and Without a Diagnosis of Gestational Diabetes

“…In a case-control study 12 ( n = 206 cases and n = 286 controls) in China, older maternal age was also associated with risk of developing GD. Findings in Southern Brazil of two cohorts 13 of women with GD, separated by 20 years, showed a mean age of 31 ± 7 years ( n = 375) and 30 ± 6 years ( n = 216). This relationship between age and GD was evident in the present study, in which the mean age of the cases was higher than that of the controls.…”

“…This relationship between age and GD was evident in the present study, in which the mean age of the cases was higher than that of the controls. [12][13][14] The cases had a greater chance of being overweight and obese than the controls. Feleke 14 also relates the previous BMI and a higher chance of developing GD in a case-control study developed in Ethiopia in the period from January to June 2016, in which the cases had 2.96 times greater chance of having a BMI !…”

“…This relationship between age and GD was evident in the present study, in which the mean age of the cases was higher than that of the controls. 12 13 14 …”