Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study

Okamura, Hiroki; Ishikawa, Kentaro; Kudo, Yoshifumi; Matsuoka, Akira; Maruyama, Hiroshi; Emori, Haruka; Yamamura, Ryo; Hayakawa, Chikara; Tani, Soji; Tsuchiya, Kiyoshi; Shirahata, Toshiyuki; Toyone, Tomoaki; Nagai, Takashi; Inagaki, Kenji

doi:10.1371/journal.pone.0237454

Cited by 28 publications

(32 citation statements)

References 40 publications

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“…The association between frailty and osteosarcopenia has been well investigated; however, the association appears to vary depending on the definition of frailty. The frailty phenotype [41] is frequently used to define frailty and has been reported to be associated with osteosarcopenia [8,23]. An association between frailty and osteosarcopenic obesity has also been reported.…”

Section: Frailtymentioning

confidence: 99%

“…An association between osteosarcopenia and chronic diseases has been reported. The associations between osteosarcopenia and peptic disease [24], inflammatory arthritis [24], diabetes (only in men) [23], and kidney dysfunction [8] have been reported. There are reports of an association between a number of chronic diseases (3 or more) [23] and osteosarcopenia.…”

Section: Comorbiditymentioning

confidence: 99%

“…Sarcopenia is strongly associated with falls, disability, disease, hospitalization, and death [7]. Osteopenia/osteoporosis and sarcopenia have proven their association in a meta-analysis [8]. Therefore, considering both osteopenia/osteoporosis and sarcopenia at the same time is a key strategy to prevent disability and poor QOL.…”

Section: Introductionmentioning

confidence: 99%

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Related Factors and Clinical Outcomes of Osteosarcopenia: A Narrative Review

et al. 2021

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Osteopenia/osteoporosis and sarcopenia are common geriatric diseases among older adults and harm activities of daily living (ADL) and quality of life (QOL). Osteosarcopenia is a unique syndrome that is a concomitant of both osteopenia/osteoporosis and sarcopenia. This review aimed to summarize the related factors and clinical outcomes of osteosarcopenia to facilitate understanding, evaluation, prevention, treatment, and further research on osteosarcopenia. We searched the literature to include meta-analyses, reviews, and clinical trials. The prevalence of osteosarcopenia among community-dwelling older adults is significantly higher in female (up to 64.3%) compared to male (8–11%). Osteosarcopenia is a risk factor for death, fractures, and falls based on longitudinal studies. However, the associations between osteosarcopenia and many other factors have been derived based on cross-sectional studies, so the causal relationship is not clear. Few studies of osteosarcopenia in hospitals have been conducted. Osteosarcopenia is a new concept and has not yet been fully researched its relationship to clinical outcomes. Longitudinal studies and high-quality interventional studies are warranted in the future.

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Section: Frailtymentioning

confidence: 99%

Section: Comorbiditymentioning

confidence: 99%

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Related Factors and Clinical Outcomes of Osteosarcopenia: A Narrative Review

et al. 2021

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“…Gender, low body mass index, comorbidities, such as diabetes and kidney dysfunction, low levels of Vitamin D, reduced insulin-like growth factor-1, and malnutrition have been associated with osteosarcopenia. 24 Our findings showed that in patients with osteosarcopenia, female patients were significantly more common and body mass index was significantly lower compared to patients without osteosarcopenia. On the other hand, there were no differences in comorbidities (diabetes and cardiovascular disease), serum creatinine level (0.77 vs 0.79 mg/dL; P = .32), serum calcium level (9.2 vs 9.1 mg/dL; P = .44), serum Alb level (3.9 vs 3.8 g/dL; P = .72), serum prealbumin level (23.6 vs 23.9 mg/ dL; P = .59), serum transferrin level (227 vs 245 mg/dL; P = .17), and serum retinol-binding protein level (2.8 vs 2.9 mg/dL; P = .49)…”

Section: Discussionmentioning

confidence: 45%

Osteosarcopenia is a potential predictor for the prognosis of patients who underwent hepatic resection for colorectal liver metastases

Furukawa

Haruki

Taniai

et al. 2021

Annals of Gastroent Surgery

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Aim: We investigated the prognostic impact of osteosarcopenia, which is the combination of osteopenia and sarcopenia, in patients with colorectal liver metastases (CRLM) after hepatic resection.Methods: One hundred and eighteen patients were analyzed retrospectively.Osteopenia was evaluated with computed tomographic measurement of pixel density in the midvertebral core of the 11th thoracic vertebra. Sarcopenia was evaluated with psoas muscle areas at the third lumbar vertebra. Osteosarcopenia was defined as the concomitant occurrence of osteopenia and sarcopenia.Results: Osteosarcopenia was identified in 38 (32%) of the patients. In univariate analysis, the overall survival was significantly worse in patients with lymph node metastases (P = .01), extrahepatic lesion (P = .01), sarcopenia (P = .02), osteosarcopenia (P < .01), Glasgow Prognostic Score (GPS) 1 or 2 (P = .05), and curability R 1 or 2 (P = .04). In multivariate analysis, lymph node metastases (P < .01), osteosarcopenia (P < .01), and GPS 1 or 2 (P = .03) were independent and significant predictors of the overall survival. In patients with osteosarcopenia, there were more women than men and body mass index was lower compared to patients without osteosarcopenia. Conclusion:Osteosarcopenia was the strong predictor for outcomes in patients who underwent liver resection for CRLM.

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“…Osteosarcopenia is a newly described syndrome that entails the co-existence of osteoporosis and sarcopenia [ 7 ]. It is reportedly associated with chronic diseases [ 8 , 9 ], the endocrine system [ 10 , 11 ], frailty [ 8 , 12 ], nutritional status [ 13 ], and physical function [ 14 ]. While osteosarcopenia is associated with declining physical function, sarcopenia and osteoporosis independently are not always associated with physical function in community-dwelling older adults [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Osteosarcopenia, the co-existence of osteoporosis and sarcopenia, is associated with social frailty in older adults

et al. 2021

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Background Osteosarcopenia is a newly described, aging-associated condition. Social frailty is an important condition whose prevalence may have risen by physical distancing during the coronavirus disease 2019 pandemic. However, the relationship between these two remains unclear. Aims To examine the association between osteosarcopenia and social frailty. Methods This cross-sectional study was conducted using data from outpatients visiting general geriatric hospital frailty clinics. Bone mineral density (BMD) and muscle mass were measured using dual X-ray absorptiometry. Osteoporosis was defined as a BMD of < 70% of the young adult mean, according to the Japan Osteoporosis Society. Sarcopenia was diagnosed as per the Asian Working Group for Sarcopenia 2019 recommendation. Osteosarcopenia was defined as the co-existence of osteoporosis and sarcopenia. We defined social frailty using a questionnaire comprising four items: general resources, social resources, social behavior, and basic social needs. Ordinal logistic regression analysis was performed with social frailty status and osteosarcopenia as the dependent and independent variables, respectively. Results We included 495 patients (mean age = 76.5 ± 7.2 years) in the analysis; of these, 58.2% were robust and 17.2%, 13.5%, and 11.1% had osteoporosis alone, sarcopenia alone, and osteosarcopenia, respectively. Social frailty prevalence increased stepwise from 8.0% in robust patients to 11.8%, 17.9%, and 29.1% among those with osteoporosis alone, sarcopenia alone, and osteosarcopenia, respectively ( P < 0.001). Logistic regression analysis revealed that only osteosarcopenia was significantly associated with social frailty (pooled odds ratio: 2.117; 95% confidence interval: 1.104–4.213). Discussion Comprehensive assessment of osteosarcopenia and social frailty is needed for disability prevention in older adults.

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Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study

Cited by 28 publications

References 40 publications

Related Factors and Clinical Outcomes of Osteosarcopenia: A Narrative Review

Related Factors and Clinical Outcomes of Osteosarcopenia: A Narrative Review

Osteosarcopenia is a potential predictor for the prognosis of patients who underwent hepatic resection for colorectal liver metastases

Osteosarcopenia, the co-existence of osteoporosis and sarcopenia, is associated with social frailty in older adults

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