Risk for Late-onset Blood-culture Proven Sepsis in Very-low-birth Weight Infants Born Small for Gestational Age

Tröger, Birte; Göpel, Wolfgang; Faust, Kirstin; Müller, Thomas S.; Jorch, Gerhard; Felderhoff-Müser, Ursula; Gortner, Ludwig; Heitmann, Friedhelm; Hoehn, Thomas; Kribs, Angela; Laux, Reinhard; Roll, Claudia; Emeis, Michael; Mögel, Michael; Siegel, Jens; Vochem, Matthias; Wense, A. von der; Wieg, Christian; Herting, Egbert; Härtel, Christoph

doi:10.1097/inf.0000000000000031

Cited by 82 publications

(59 citation statements)

References 27 publications

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“…Again, these are known risk factors for the development of sepsis in this population. [12][13][14] In all cases a p value of 5% or less was set as the definition of statistical significance.…”

Section: Methodsmentioning

confidence: 99%

Greater Mortality and Morbidity in Extremely Preterm Infants Fed a Diet Containing Cow Milk Protein Products

Abrams

Schanler

Lee³

et al. 2014

Breastfeeding Medicine

152

120

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Background: Provision of human milk has important implications for the health and outcomes of extremely preterm (EP) infants. This study evaluated the effects of an exclusive human milk diet on the health of EP infants during their stay in the neonatal intensive care unit. Subjects and Methods: EP infants <1,250 g birth weight received a diet consisting of either human milk fortified with a human milk protein-based fortifier (HM) (n = 167) or a diet containing variable amounts of milk containing cow milk-based protein (CM) (n = 93). Principal outcomes were mortality, necrotizing enterocolitis (NEC), growth, and duration of parenteral nutrition (PN). Results: Mortality (2% versus 8%, p = 0.004) and NEC (5% versus 17%, p = 0.002) differed significantly between the HM and CM groups, respectively. For every 10% increase in the volume of milk containing CM, the risk of sepsis increased by 17.9% ( p < 0.001). Growth rates were similar between groups. The duration of PN was 8 days less in the subgroup of infants receiving a diet containing <10% CM versus ‡10% CM ( p < 0.02). Conclusions: An exclusive human milk diet, devoid of CM-containing products, was associated with lower mortality and morbidity in EP infants without compromising growth and should be considered as an approach to nutritional care of these infants.

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Section: Methodsmentioning

confidence: 99%

Greater Mortality and Morbidity in Extremely Preterm Infants Fed a Diet Containing Cow Milk Protein Products

Abrams

Schanler

Lee³

et al. 2014

Breastfeeding Medicine

152

120

View full text Add to dashboard Cite

show abstract

“…Tröger et al 25 reported that SGA increased the incidence of late onset culture proven sepsis in VLBW in fants. Thymic atrophy and lymphopenia and deficiencies in humoral responses in SGA infants were reported.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Pregnancy Disorders Causing Preterm Delivery on In-Hospital Outcomes in Preterm Infants at Less than 32 Weeks of Gestation

et al. 2017

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Objective:We assessed the influence of small for gestational age (GA) with placental disorders (SGAP) and histologic chorioamnionitis (HCA) on the inhospital outcomes of preterm infants. Methods: Preterm infants with a GA <32 weeks born at Seoul National University Hospital between 2007 and 2014 were included and divided into 4 groups according to the presence of SGAP and HCA: group 1, SGAP only; group 2, HCA only; group 3, both SGAP and HCA; and group 4, no SGAP or HCA. Multivariate logistic regression was done to compare neonatal outcomes including death, moderate to severe bronchopulmonary dysplasia (BPD) or death, patent ductus arteriosus with treat ment, sepsis, necrotizing enterocolitis ≥stage 2b, and intraventricular hemorrhage ≥grade 3. Results: A total of 572 infants were included. There were 77 patients (13.5%) in group 1, 226 patients (39.5%) in group 2, and 24 patients (4.2%) in group 3. After adjusting for GA, cesarean section, 5 minute Apgar score, multiple pregnancy, premature rupture of membrane before 18 hours prior to delivery, and preeclampsia, group 1 showed higher risks of mortality (adjusted odds ratio [aOR] 3.15, 95% confidence interval [CI] 1.138.80), moderate to severe BPD or death (aOR 9.12, 95% CI 3.98 20.90), sepsis (aOR 2.12, CI 1.014.46), and pulmonary hypertension (aOR 3.26, 95% CI 1.159.22) compared with group 4. There were no significant differences in mortality and inhospital outcomes between groups 2 and 4 or between groups 3 and 4. Conclusion: Close monitoring and early intervention are suggested in SGAP infants.

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“…Erken başlangıçlı sepsis riski; prematürelik, bağışıklık sisteminin olgunlaşmaması, maternal Group B Streptococcal kolonizasyon, erken membran rüptürü ve maternal intra-amniyotik infeksiyonlarla ilişkilidir (4) . (7) .…”

Section: Prematüritelik Ve Infeksiyon Sorunuunclassified

The expected problems in very low birth weight prematures and outcomes

Celayir¹

2015

Tccd

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Risk for Late-onset Blood-culture Proven Sepsis in Very-low-birth Weight Infants Born Small for Gestational Age

Abstract: SGA contributes to the risk of late-onset sepsis in VLBW infants. Future studies are needed to investigate the underlying pathophysiology to guide individualized preventive measures in this vulnerable subgroup.

Cited by 82 publications

References 27 publications

Greater Mortality and Morbidity in Extremely Preterm Infants Fed a Diet Containing Cow Milk Protein Products

Greater Mortality and Morbidity in Extremely Preterm Infants Fed a Diet Containing Cow Milk Protein Products

The Influence of Pregnancy Disorders Causing Preterm Delivery on In-Hospital Outcomes in Preterm Infants at Less than 32 Weeks of Gestation

The expected problems in very low birth weight prematures and outcomes

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