Risk indicators for recurrent aphthous ulcers among adults in the US

Chattopadhyay, Amit; Chatterjee, Sharmila

doi:10.1111/j.1600-0528.2007.00329.x

Cited by 69 publications

(61 citation statements)

References 30 publications

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“…The hypotheses of its pathogenesis are numerous. Several studies have reported a relationship between RAS and various causes but the results are conflicting (Scully 2006;Chattopadhyay and Chatterjee 2007). Different subgroups of patients appear to have different causes for the occurrence of RAS.…”

confidence: 99%

Increased Anxiety Level and High Salivary and Serum Cortisol Concentrations in Patients with Recurrent Aphthous Stomatitis

Albanidou-Farmaki

Poulopoulos

Epivatianos

et al. 2008

Tohoku J. Exp. Med.

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Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal disorders. The aim of the study was to determine any association between anxiety levels and concentrations of salivary and serum cortisol in patients with RAS. It has been suggested that stress with its presumed effects on the immune system, constitutes one of the major causative agents of RAS. The concentrations of salivary and serum cortisol were measured in 38 patients with recurrent aphthous stomatitis, and 38 healthy controls. Salivary and serum cortisol levels were measured using a Luminenscent Immunoassay (LIA) method. Anxiety levels were evaluated using Spielberger's State-Trait Anxiety Inventory which measures both trait anxiety as a general aspect of personality (STAI-T) and state anxiety as a response to a specific situation (STAI-S). The salivary cortisol levels were 1.44 (± 0.58) μ g dl -1 in RAS patients and 0.91 (± 0.56) μ g dl -1 in controls ( p = 0.001), while the serum cortisol levels were 3.13 (± 1.59) μ g dl -1 in RAS patients and 1.89 (± 1.11) μ g dl -1 in controls ( p = 0.001). The state anxiety levels (STAI-S) were 48.85 (± 9.7) in RAS group and 39.45 (± 7.5) in control group ( p = 0.001). The trait anxiety levels (STAI-T) were 49.78 (± 13.02) in RAS group and 38.49 (± 10.31) in control group ( p = 0.001). Salivary and serum cortisol concentrations and state and trait anxiety levels in RAS were significantly higher than those in the control group. Our results suggest that stress may be involved in the pathogenesis of RAS. recurrent aphthous stomatitis; anxiety; salivary cortisol; serum cortisol; pathogenesis.Tohoku

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confidence: 99%

Increased Anxiety Level and High Salivary and Serum Cortisol Concentrations in Patients with Recurrent Aphthous Stomatitis

Albanidou-Farmaki

Poulopoulos

Epivatianos

et al. 2008

Tohoku J. Exp. Med.

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“…It is clinically diagnosed by painful, recurrent, yellowish white or grey, single or multiple, and round or oval ulcers with erythematous margins mainly confined to non-keratinized oral mucosa. 7,18,23,24 Its pathogenesis remains uncertain but is probably multifactorial. 7,18,23,24 The need for consideration of psychological factors in the pathogenesis of oral disease has been increasingly acknowledged over the last decades and many studies have highlighted the psycho-social impact of oral conditions.…”

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confidence: 99%

“…7,18,23,24 Its pathogenesis remains uncertain but is probably multifactorial. 7,18,23,24 The need for consideration of psychological factors in the pathogenesis of oral disease has been increasingly acknowledged over the last decades and many studies have highlighted the psycho-social impact of oral conditions. Oral health and status impacts on people's daily living, quality of life and overall well-being, therefore, the clinical status, psychological factors, dental needs and patients' perceptions should be assessed.…”

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confidence: 99%

Psychological profiles in patients with recurrent aphthous ulcers

AL‐Omiri

Karasneh

Lynch

2012

International Journal of Oral and Maxillofacial Surgery

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“…1 Family history is the most consistent factor associated with RAS. 2 Additional factors associated with the disease include nutritional deficiencies, stress, and systemic diseases.…”

Section: Discussionmentioning

confidence: 96%

Recurrent Oral Ulcers

Stoopler

Sollecito

2015

JAMA

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A 44-year-old man with a history of gastroesophageal reflux disease and anxiety presents for evaluation of mouth ulcers recurring for the past 2 years. The painful ulcers resolve within 2 weeks but recur on different mucosal surfaces. He denies new medications, foods, or oral hygiene products and involvement of cutaneous or other mucosal surfaces. He is uncertain whether he has a family history of oral ulcers. He was previously prescribed anesthetic rinses and fluconazole, without benefit. His current medications include omeprazole and lorazepam. Intraoral examination demonstrates an ulcer with a pseudomembrane and erythematous halo on the left lateral surface of the tongue (Figure). Physical examination results are otherwise normal.Quiz at jama.com WHAT WOULD YOU DO NEXT?

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Risk indicators for recurrent aphthous ulcers among adults in the US

Abstract: This study establishes the prevalence of RAU among adults in the US and demonstrates that whereas cigarette smoking is associated with lesser odds, low insulin levels might be independently associated with greater odds of RAU.

Cited by 69 publications

References 30 publications

Increased Anxiety Level and High Salivary and Serum Cortisol Concentrations in Patients with Recurrent Aphthous Stomatitis

Increased Anxiety Level and High Salivary and Serum Cortisol Concentrations in Patients with Recurrent Aphthous Stomatitis

Psychological profiles in patients with recurrent aphthous ulcers

Recurrent Oral Ulcers

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