Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of <b><i>TMC/EVER</i></b> Alterations

Abstract

Background: Renal transplant recipients (RTRs) have an increased risk of developing nonmelanoma skin cancer, mainly cutaneous squamous cell carcinoma (cSCC). Two genes (TMC6/EVER1 and TMC8/EVER2), mutated in epidermodysplasia verruciformis (EV) patients with an increased risk of cSCC development, contain numerous single-nucleotide polymorphisms (SNPs). Aim: To evaluate the effect of SNPs in both TMC/EVER genes on the different susceptibilities of RTRs to cSCC. Method: We determined the occurrence of cSCC in 105 RTRs who were transplanted at least 7 years previously and investigated the frequency of 26 SNPs within both TMC/EVER genes in severely affected (n = 16) as well as in nonaffected RTRs (n = 25). Results: Our data did not indicate a significant association between any SNP genotype and risk of cSCC development in RTRs. Conclusion: To clarify the correlation between SNPs in both TMC genes and cSCC development in RTRs, integrated investigations of large cohorts including both RTRs and immunocompetent individuals with consideration of cSCC status, SNP genotype and human papillomavirus status might be necessary.

Cutaneous Squamous Cell Carcinoma Arising in Immunosuppressed Patients: A Systematic Review of Tumor Profiling Studies

“… 2015 16 RTRs with SCC and 25 RTRs without SCC 26 SNVs within both TMC and EVER genes No significant association was found between any SNV genotype within TMC6/EVER1 and risk of SCC development in RTRs. TMC8/EVER2 Burger et al . 2015 16 RTRs with SCC and 25 RTRs without SCC 26 SNVs within both TMC and EVER genes No significant association was found between any SNV genotype within TMC8/EVER2 and risk of SCC development in RTRs.…”

Risk of penile tumor development in Caucasian individuals is independent of the coding variant rs7208422 in the TMC8 (EVER2) gene

“…It was not possible to analyse an internal healthy control group for comparison within the present study. Therefore, published genotype data (from peripheral blood) of rs7208422 from Caucasian control groups of several published case-control studies were used (9)(10)(11)(12)29,30). After merging these studies, genotype data from 3,810 control cases were available.…”

The role of analysis of EVER2 haplotypes in actinic keratosis

“…Wszystkie te wyniki uzyskano u pacjentów, którzy nie mieli istotnych zaburzeń immunologicznych [9,10,14,15]. Należy podkreślić, że w opublikowanym w 2015 r. badaniu przeprowadzonym u pacjentów leczonych immunosupresyjnie z powodu przeszczepów narządowych, u których dodatkowo występo-wały SCC, nie stwierdzono zaburzeń genów EVER, co pokazuje, że ich udział w kancerogenezie może być jeszcze przedmiotem dyskusji [16]. W przedstawionej pracy analizowaliśmy haplotypy genu EVER2 złożone z polimorfizmów, które uzyskały istotność statystyczną w poprzednich naszych pracach oraz w dostępnych badaniach nad AK i SCC.…”