Risk of Dyslipidemia in Obese Young Adult Subjects as Measured by Various Obesity Indices

Yudin, Roghaya; Aman, Andi Makbul; Rasyid, Haerani; Bakri, Syakib; Sanusi, Himawan; Daud, Nu’man As; Zainuddin, Andi Alfian

doi:10.14740/jem819

Cited by 8 publications

(9 citation statements)

References 17 publications

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“…The control group in the DZ population demonstrates a higher BMI, compared with the MZ population, along with higher levels of VLDL metabolites in the DZ control group and higher levels of HDL in the MZ control group. This is in line with previous reports on dyslipidemia and obesity 70 , 71 . To cope with this issue, future work should envision individual reference intervals, that exploit longitudinal subject-specific data rather than looking into population ranges 72 .…”

Section: Discussionsupporting

confidence: 94%

Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study

Delanote,

Correa Rojo,

Wells

et al. 2024

Sci Rep

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Mental disorders are complex disorders influenced by multiple genetic, environmental, and biological factors. Specific microbiota imbalances seem to affect mental health status. However, the mechanisms by which microbiota disturbances impact the presence of depression, stress, anxiety, and eating disorders remain poorly understood. Currently, there are no robust biomarkers identified. We proposed a novel pyramid-layer design to accurately identify microbial/metabolomic signatures underlying mental disorders in the TwinsUK registry. Monozygotic and dizygotic twins discordant for mental disorders were screened, in a pairwise manner, for differentially abundant bacterial genera and circulating metabolites. In addition, multivariate analyses were performed, accounting for individual-level confounders. Our pyramid-layer study design allowed us to overcome the limitations of cross-sectional study designs with significant confounder effects and resulted in an association of the abundance of genus Parabacteroides with the diagnosis of mental disorders. Future research should explore the potential role of Parabacteroides as a mediator of mental health status. Our results indicate the potential role of the microbiome as a modifier in mental disorders that might contribute to the development of novel methodologies to assess personal risk and intervention strategies.

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Section: Discussionsupporting

confidence: 94%

Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study

Delanote,

Correa Rojo,

Wells

et al. 2024

Sci Rep

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“…This relationship remained signi cant after adjusting for age and gender variables. Our nding is consistent with Yudin et al study (12). Various studies also reported that obesity contributes to the release of large amounts of free fatty acids by lipolysis, which leads to dyslipidemia (22,23).…”

Section: Discussionsupporting

confidence: 93%

“…Abnormalities in lipid pro le in obese patients include elevation in triglyceride (TG), very low-density lipoprotein (VLDL), apolipoprotein B (Apo B), nonhigh-density lipoprotein cholesterol (non-HDL), small dense low-density lipoprotein (sdLDL), low-density lipoprotein (LDL) levels, but decreasing in HDL and Apo A1 (10,11). Visceral adipose tissue (VAT), which is mainly increased in obese individuals, causes elevated TG, sdLDL, and low HDL; also, the accumulation of excess fat in the abdomen is the main cause of insulin resistance, which both are related to the development of atherosclerosis and signi cantly in uences coronary artery disease (12).…”

Section: Introductionmentioning

confidence: 99%

Associations between Body Mass Index (BMI) and Dyslipidemia: Results from the PERSIAN Guilan cohort study (PSCS)

Shahraz,

Joukar,

Yeganeh

et al. 2023

Preprint

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Background: Given the high prevalence of obesity and its relationship with dyslipidemia, both as risk factors for cardiovascular diseases, this study was conducted with the aim of investigating the relationship between BMI and dyslipidemia in the Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan cohort study (PGCS) population. Methods: In this cross-sectional study, demographic and biochemical data were collected from 10519 participants of the PGCS population aged 35-70 years in Some’e Sara County, Guilan, Iran. Participants were divided into two groups with and without dyslipidemia and were compared based on different levels of BMI. All data were analyzed using SPSS version 16 software with a significance level<0.05. Results: The average age of the participants is 51.52 ± 8.90 years. The prevalence of dyslipidemia in all participants was equal to 75.8 %. Most of the people with dyslipidemia were in the age group of 45-54 years. Among those with dyslipidemia, 41.2 % and 35.5 % had overweight and obesity, respectively. Furthermore, individuals with dyslipidemia demonstrated higher proportions of women, employed individuals, rural residents, those with higher socio-economic status, elevated BMI, and lower levels of physical activity, (P<0.001). In the unadjusted model, there was a positive association between BMI and the prevalence of dyslipidemia (OR=1.09, 95% confidence interval (CI): 1.08-1.10), indicating that for one-unit increase in participants' BMI, the probability of having dyslipidemia increased by 9%, which was remained statistically significant even after adjusting (OR=1.07, 95% CI: 1.06-1.08) (P<0.001). Conclusion: The risk of dyslipidemia increases in the group with high BMI and low physical activity compared to others. Therefore, weight loss should be recommended for all those with a high BMI. Also, community-based education would be helpful to increase public knowledge.

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“…Moreover, Yudin R et al concluded that Obesity based on BMI is related to HDL-C and TG when they observed the lower concentration of HDL-C and higher concentration of TG in obese patients similar to this study. 24 The pathophysiology behind Obesity is multifactorial, including hepatic overproduction of VLDL, decreased circulating TG lipolysis and impaired peripheral FFA trapping, increased FFA fluxes from adipocytes to the liver and other tissues, and the formation of small dense LDL in the case group compared to the control group in this study. 25 Ranganathan S, et al concurred with these findings, stating that people with high BMI had a higher risk of dyslipidaemia than those with normal BMI.…”

Section: Discussionmentioning

confidence: 67%

Effect of Increasing Body Mass Index On the Activity of Matrix Metalloproteinase-2

Jain

Das²,

Saxena

et al. 2022

Int J Life Sci Pharm Res

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The Increasing Body Mass Index is one of the major concerns in today's lifestyle, which may give rise to various disorders. Studies have suggested that Matrix Metalloproteinases (MMPs) are associated with Obesity and cardiovascular disease. This study aimed to evaluate the serum activity of Matrix Metalloproteinase-2 in overweight patients with anthropometric measurements to assess the effect of body mass index in MMP-2 activity. In this Age and sex matched case-control study the participants were selected in 2:1 ratio (219 cases and 108 controls). In this study Body Mass Index, Blood Pressure, and other biochemical parameters i.e. Fasting Blood Sugar (FBS), Total Cholesterol (TC), Triglycerides (TG), High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C) along with MMP-2 were measured through semi-autoanalyzer and ELISA respectively. There was an increased concentration of FBS in overweight patients compared to the control group, which was statistically significant. In the case of lipid profile, there was an elevated concentration of TC, TG, and LDLC in the overweight population when compared to the control group and the findings were statistically significant, while HDL-C was significantly elevated in the control group compared to the case group. With respect to blood pressure, a significant increase was observed in systolic and diastolic blood pressure. In this study, there was a significant elevation of MMP-2 in the case group compared to the control group, which was positively associated with Body Mass Index. The outcome of this study revealed that increasing body weight might be the root cause of developing several life-threatening risk factors if not considered at initial level. Furthermore, altered concentration of MMP-2 in overweight patients may highlight cardiovascular Risk in these patients. (authors need to rewrite the abstract systematically. In addition, there are many spelling and grammatical errors.)

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Risk of Dyslipidemia in Obese Young Adult Subjects as Measured by Various Obesity Indices

Cited by 8 publications

References 17 publications

Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study

Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study

Associations between Body Mass Index (BMI) and Dyslipidemia: Results from the PERSIAN Guilan cohort study (PSCS)

Effect of Increasing Body Mass Index On the Activity of Matrix Metalloproteinase-2

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