2023
DOI: 10.1016/j.heliyon.2023.e13811
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Risk score = LncRNAs associated with doxorubicin metabolism can be used as molecular markers for immune microenvironment and immunotherapy in non-small cell lung cancer

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Cited by 10 publications
(4 citation statements)
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“…As clinical features and TNM stage aggressiveness increased, mRNAsi scores also showed a gradual increase. Tumor stemness has been associated with cancer metastasis, drug resistance, recurrence, and poor prognosis 47 . Additionally, the lack of statistically significant difference in OS between the high mRNAsi group and the low mRNAsi group may suggest that tumor progression alone may not be the sole prognostic factor.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As clinical features and TNM stage aggressiveness increased, mRNAsi scores also showed a gradual increase. Tumor stemness has been associated with cancer metastasis, drug resistance, recurrence, and poor prognosis 47 . Additionally, the lack of statistically significant difference in OS between the high mRNAsi group and the low mRNAsi group may suggest that tumor progression alone may not be the sole prognostic factor.…”
Section: Discussionmentioning
confidence: 99%
“…Tumor stemness has been associated with cancer metastasis, drug resistance, recurrence, and poor prognosis. 47 Additionally, the lack of statistically significant difference in OS between the high mRNAsi group and the low mRNAsi group may suggest that tumor progression alone may not be the sole prognostic factor. Tumor tissue composition, including tumor cells and other cell types, can affect the assessment of clinical features by mRNAsi and partially explain the lack of statistical significance in OS differences between the two groups.…”
Section: Discussionmentioning
confidence: 99%
“…For example, lncRNA H19 has been shown to increase the HMGA2-mediated epithelial-mesenchymal transformation (EMT) in pancreatic ductal adenocarcinoma (PDAC) by antagonizing let-7, at least partially promoting PDAC cells [ 9 ]. In the future, lncRNA is expected to become a new biomarker to study the pathogenesis of diseases and guide disease treatment [ [10] , [11] , [12] , [13] , [14] ]. Therefore, it is of great significance to study the associations between lncRNA and diseases.…”
Section: Introductionmentioning
confidence: 99%
“…Although epigenetic modifiers have shown promise as targets for cancer treatment, their efficacy as standalone therapies remain limited. Combinatorial approaches that integrate epigenetic therapies with other anti-tumor treatments offer a more comprehensive strategy for maximizing therapeutic outcomes ( Ye et al, 2021 ; Li et al, 2022 ; Lin et al, 2023 ).…”
mentioning
confidence: 99%