Risks of recurrent stroke and all serious vascular events after spontaneous intracerebral haemorrhage: pooled analyses of two population-based studies

Li, Linxin; Poon, Michael T C; Samarasekera, Neshika; Perry, Luke A; Moullaali, Tom J; Rodrigues, Mark; Loan, James J M; Stephen, Jacqueline; Lerpiniere, Christine; Tuna, M A; Gutnikov, Sergei A.; Küker, Wilhelm; Silver, L E; Salman, Rustam Al-Shahi; Rothwell, Peter M.

doi:10.1016/s1474-4422(21)00075-2

Cited by 72 publications

(101 citation statements)

References 43 publications

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“…Event rates in RESTART were comparable to community-based studies in the UK. Blood pressure was controlled comparably between groups throughout follow-up. We minimized attrition bias by achieving greater than 97% completeness of extended follow-up.…”

Section: Discussionmentioning

confidence: 99%

“… Even after these risk factors are accounted for, survivors of spontaneous ICH are at higher risk of myocardial infarction and ischemic stroke than the general population, and their risk of all hemorrhagic or ischemic major vascular events is higher still at approximately 8% per year. Antiplatelet agents may benefit survivors of spontaneous ICH, but their effect on major vascular events is uncertain. …”

Section: Introductionmentioning

confidence: 99%

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Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage

et al. 2021

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IMPORTANCE The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up to 5 years after intracerebral hemorrhage (ICH) that had occurred during antithrombotic (antiplatelet or anticoagulant) therapy.OBJECTIVES To monitor adherence, increase duration of follow-up, and improve precision of estimates of the effects of antiplatelet therapy on recurrent ICH and major vascular events.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage

et al. 2021

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“…In the present single-center pilot study, we aimed to test the diagnostic value of FLP and SAH on admission CT in a cohort of symptomatic lobar ICH patients in whom pathological diagnosis was available mostly as hematoma evacuation sample. Furthermore, most patients survived the index event, as is true for the majority (≈57%) of the symptomatic lobar ICH population [ 5 ]. This cohort can be therefore considered paradigmatic of survivors from lobar ICH presentation in whom making a diagnosis of CAA has particular relevance.…”

Section: Introductionmentioning

confidence: 99%

Cerebral amyloid angiopathy-related acute lobar intra-cerebral hemorrhage: diagnostic value of plain CT

et al. 2021

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Background Diagnosing probable cerebral amyloid angiopathy (CAA) after lobar intra-cerebral hemorrhage (l-ICH) currently relies on the MR-based modified Boston criteria (mBC). However, MRI has limited availability and the mBC have moderate sensitivity, with isolated l-ICH being classified as “possible CAA”. A recent autopsy-based study reported potential value of finger-like projections (FLP) and subarachnoid hemorrhage (SAH) on acute CT. Here we assessed these markers’ performance in a cohort most of whom survived the index episode. Methods We included all patients from a prospective pathology database with non-traumatic l-ICH, admission CT and available tissue sample showing no alternative cause. CT was assessed by two blinded independent neuroradiologists. Interobserver reproducibility was almost perfect for SAH and substantial for FLP. Results Sixteen patients were eligible [age 65.8 ± 7.2 yrs; hematoma volume: 39(26, 71)mls; hematoma evacuation sample 15 patients; autopsy one patient]. MRI was available in 11 patients. ICH-related death affected six patients. Aβ40–42 immunohistochemistry revealed CAA in seven patients (44%). SAH and FLP were present in 12/16 (75%) and 10/16 (62%) patients, respectively. SAH had 100% sensitivity for CAA but low specificity; FLP had lower performance. Using either pathology or MRI as reference standard yielded essentially similar results. All patients with possible CAA on MRI but CAA on pathology had SAH. Conclusions In patients with moderate-size l-ICH who mostly survived the index event, SAH had perfect sensitivity and better performance than FLP. In addition, SAH appeared to add onto MRI in possible CAA, the clinically most relevant scenario. Studies in larger samples are however warranted.

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“… 2 Stroke was divided into two types, hemorrhagic and ischemic strokes. 3 It has been reported that ischemic stroke (IS) constitutes about 85% of all stroke patients. 4 Even though many efforts are being put into developing new strategies to treat ischemic stroke, the only effective treatment for stroke is intravascular thrombolysis or thrombectomy.…”

Section: Introductionmentioning

confidence: 99%

LncRNA FTX Regulates Angiogenesis Through miR-342-3p/SPI1 Axis in Stroke

Gao¹,

Wang²

2021

NDT

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Background Long non-coding RNAs (lnc-RNAs) and microRNAs (miRNAs) play key roles in the development of stroke. However, the role of lncRNA FTX in stroke is limited known. Methods Real-time polymerase chain reaction (real-time PCR) assays were used to measure the expression of lncRNA FTX, miR-342-3p and SPI1. Western blot assays were employed to examine SPI1 protein expression. The cell viability was measured by CCk8 assay. Cell migration was detected by wound healing assays and transwell assays. Angiogenesis was evaluated by matrigel tube formation assays. The interaction between lncRNA FTX, miR-342-3p and SPI1 was confirmed by site-directed mutagenesis and luciferase assays. Results The expression of lncRNA FTX was down-regulated in blood sample from stroke patients, MAO mice tissues and OGD/R treated BMECs. Overexpression of lncRNA FTX could increase the cell viability, migration and angiogenesis in OGD/R treated BMECs. LncRNA FTX could act as a ceRNA for miR-342-3p. Furthermore, miR-342-3p inhibition increased migration and angiogenesis in OGD/R-induced BMECs. Dual-luciferase reporter assay verified that SPI1 was a target of miR-342-3p. Conclusion In summary, lncRNA FTX enhanced the angiogenesis in stroke by acting as a sponge of miR-342-3p to regulate the expression of SPI1 level.

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Risks of recurrent stroke and all serious vascular events after spontaneous intracerebral haemorrhage: pooled analyses of two population-based studies

Cited by 72 publications

References 43 publications

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage

Cerebral amyloid angiopathy-related acute lobar intra-cerebral hemorrhage: diagnostic value of plain CT

LncRNA FTX Regulates Angiogenesis Through miR-342-3p/SPI1 Axis in Stroke

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