RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection

Abstract

RNA binding motif 3 (RBM3) is a highly conserved cold-induced RNA binding protein that is transcriptionally up-regulated in response to harsh stresses. Featured as RNA binding protein, RBM3 is involved in mRNA biogenesis as well as stimulating protein synthesis, promoting proliferation and exerting anti-apoptotic functions. Nowadays, accumulating immunohistochemically studies have suggested RBM3 function as a proto-oncogene that is associated with tumor progression and metastasis in various cancers. Moreover, emerging evidences have also indicated that RBM3 is equally effective in neuroprotection. In the present review, we provide an overview of current knowledge concerning the role of RBM3 in various cancers and neuroprotection. Additionally, its potential roles as a promising diagnostic marker for cancer and a possible therapeutic target for neuro-related diseases are discussed.

Cold‐inducible protein RBM3 mediates hypothermic neuroprotection against neurotoxin rotenone via inhibition on MAPK signalling

“…However, mild hypothermia is an aggressive clinical therapy, bearing side‐effects such as shivering, slurred speech or mumbling, slow and shallow breathing, low energy and weak pulse . This inspired the search for molecular targets with fewer side‐effects to replace therapeutic cooling and led to the discovery of RBM3 as a crucial mediator of hypothermia‐related neuroprotection …”

“…33,34 This inspired the search for molecular targets with fewer side-effects to replace therapeutic cooling and led to the discovery of RBM3 as a crucial mediator of hypothermia-related neuroprotection. [17][18][19] Researchers have previously demonstrated that ROT induces neurotoxicity by caspase activation and apoptotic cell death, accompanied by the activation of pro-apoptotic MAPK signalling pathways like p38 and JNK. [35][36][37][38][39] Our study not only corroborated these results but additionally revealed that the neuroprotective effects of mild hypothermia in a ROT-based PD cell model are mediated by RBM3.…”

“…There is growing evidence indicating that RBM3 is a crucial factor mediating hypothermia‐induced neuroprotective effects. In primary neurons and cortical organotypic slice cultures, mild hypothermia markedly increased RBM3 expression and rescued neuronal cells from forced apoptosis . In Alzheimer‐type and prion‐infected mouse models, RBM3 was identified as a crucial mediator of hypothermia‐induced neuroprotection, revealing that RBM3 induction/overexpression may provide protection not only in cases of acute brain injury but also in neurodegenerative diseases.…”

“…In primary neurons and cortical organotypic slice cultures, mild hypothermia markedly increased RBM3 expression and rescued neuronal cells from forced apoptosis. [17][18][19] In Alzheimer-type and prion-infected mouse models, RBM3 was identified as a crucial mediator of hypothermia-induced neuroprotection, 13 revealing that RBM3 induction/overexpression may provide protection not only in cases of acute brain injury but also in neurodegenerative diseases. We previously showed that the overexpression of RBM3 protects dopaminergic neuroblastoma cells SH-SY5Y from the apoptosis induced by nitric oxide (NO), ultra-violet (UV) irradiation and an overdose of retinoic acid (RA), whereas RBM3 knockdown revokes the neuroprotective effects of mild hypothermia in SH-SY5Y cells.…”

Correlation analysis of RBM3 expression in tumor stroma and prognosis of patients with non-small cell lung cancer

“…With the deepening of RBM3 research, the role of RBM3 protein in the occurrence and development of tumors has been paid more and more attention. More and more immunohistochemical studies have shown that RBM3 acts as a proto-oncogene and is associated with the progression and metastasis of various cancers[16]. The main reasons for RBM3 acting as a protooncogene were listed as follows.…”