RNA Editing is a Valuable Biomarker for Predicting Carcinogenesis in Ulcerative Colitis

Takahashi, Kazutaka; Shigeyasu, Kunitoshi; Kondo, Yoshitaka; Gotoh, Kazuyoshi; Yano, Shuya; Umeda, Yuzo; Inokuchi, Toshihiro; Xu, Caiming; Yoshida, Kazuhiro; Umeda, Hibiki; Takahashi, Toshiaki; Takeda, Sho; Yoshida, Ryuichi; Teraishi, Fuminori; Kishimoto, Hiroyuki; Mori, Yoshiko; Noma, Kazuhiro; Okugawa, Yoshinaga; Hiraoka, Sakiko; Michiue, Hiroyuki; Tazawa, Hiroshi; Matsushita, Osamu; Goel, Ajay; Fujiwara, Toshiyoshi

doi:10.1093/ecco-jcc/jjac186

Cited by 6 publications

(1 citation statement)

References 35 publications

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“…The most common types of RNA editing disorders in cancer cells are enhanced ADAR1 editing and decreased ADAR2 editing, with ADAR1 and ADAR2 being concurrently altered in some cancer cells [ 118 – 120 ]. Increased expression of ADAR1 leads to elevated RNA editing in antizyme inhibitor 1 (AZIN1), resulting in the production fo a recoded AZIN1-S376G protein that impacts cell proliferation [ 121 , 122 ]. In myeloma, excessive ADAR1 activity leads to the R701G mutation through RNA editing of Glioma-associated oncogene 1 (GLI1) transcription, affecting cancer cell proliferation and resistance to anticancer drugs [ 123 ].…”

Section: Biological Functions Of Rna Editingmentioning

confidence: 99%

RNA editing enzymes: structure, biological functions and applications

Zhang,

Zhu,

Gao

et al. 2024

Cell Biosci

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With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing. RNA editing is a ubiquitous modification in mammalian transcriptomes and is an important co/posttranscriptional modification that plays a crucial role in various cellular processes. There are two main types of RNA editing events: adenosine to inosine (A-to-I) editing, catalyzed by ADARs on double-stranded RNA or ADATs on tRNA, and cytosine to uridine (C-to-U) editing catalyzed by APOBECs. This article provides an overview of the structure, function, and applications of RNA editing enzymes. We discuss the structural characteristics of three RNA editing enzyme families and their catalytic mechanisms in RNA editing. We also explain the biological role of RNA editing, particularly in innate immunity, cancer biogenesis, and antiviral activity. Additionally, this article describes RNA editing tools for manipulating RNA to correct disease-causing mutations, as well as the potential applications of RNA editing enzymes in the field of biotechnology and therapy.

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Section: Biological Functions Of Rna Editingmentioning

confidence: 99%

RNA editing enzymes: structure, biological functions and applications

Zhang,

Zhu,

Gao

et al. 2024

Cell Biosci

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The role of ADAR1 through and beyond its editing activity in cancer

Jiao,

Xu,

Liu

et al. 2024

Cell Commun Signal

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Adenosine-to-inosine (A-to-I) editing of RNA, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, is a prevalent RNA modification in mammals. It has been shown that A-to-I editing plays a critical role in multiple diseases, such as cardiovascular disease, neurological disorder, and particularly cancer. ADARs are the family of enzymes, including ADAR1, ADAR2, and ADAR3, that catalyze the occurrence of A-to-I editing. Notably, A-to-I editing is mainly catalyzed by ADAR1. Given the significance of A-to-I editing in disease development, it is important to unravel the complex roles of ADAR1 in cancer for the development of novel therapeutic interventions.In this review, we briefly describe the progress of research on A-to-I editing and ADARs in cancer, mainly focusing on the role of ADAR1 in cancer from both editing-dependent and independent perspectives. In addition, we also summarized the factors affecting the expression and editing activity of ADAR1 in cancer.

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UDP-Glucuronosyltransferases 2A3 as a biomarker for ulcerative colitis and colon cancer

Chen

2024

Preprint

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Background Ulcerative colitis has a serious impact on the quality of life of patients and is more likely to progress to colon cancer. Early diagnosis and timely intervention of ulcerative colitis are of great significance. Methods Gene expression data of active ulcerative colitis were downloaded from the GEO database, and genes with significant differential expression were identified. Biochemical markers with diagnostic significance were selected through machine learning methods. The expression differences of the selected markers between COAD and normal control groups in the TCGA database were also understood, and the diagnostic efficacy of these markers for COAD was observed. In addition, the correlation between the selected markers and clinical indicators, as well as their predictive efficacy for the survival of COAD patients, was explored. Results Through machine learning and LASSO regression analysis, UGT2A3 was finally determined as a diagnostic marker for ulcerative colitis. It showed good diagnostic efficacy in both the training set and the external validation set. Meanwhile, UGT2A3 was significantly downregulated in COAD tissues compared to normal control tissues. The ROC curve suggested that UGT2A3 could serve as a diagnostic marker for COAD with high diagnostic efficacy, with an AUC of 0.969. Immune infiltration analysis indicated a significant negative correlation between the expression of UGT2A3 and neutrophils. Correlation analysis suggested the association of UGT2A3 with the pathological classification of colon cancer. Survival analysis showed that UGT2A3 is negatively correlated with OS, PPS, and RFS in colon cancer. Conclusion We identified UGT2A3 as a diagnostic marker for ulcerative colitis through bioinformatics methods, and verified its significant downregulation in colon cancer, as well as its predictive role in the survival of COAD patients. It may serve as a diagnostic marker for ulcerative colitis and colon cancer, and also provide certain guidance for the prognosis of colon cancer patients.

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RNA Editing is a Valuable Biomarker for Predicting Carcinogenesis in Ulcerative Colitis

Cited by 6 publications

References 35 publications

RNA editing enzymes: structure, biological functions and applications

RNA editing enzymes: structure, biological functions and applications

The role of ADAR1 through and beyond its editing activity in cancer

UDP-Glucuronosyltransferases 2A3 as a biomarker for ulcerative colitis and colon cancer

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