Abstract:Despite of the remarkable success of RNA interference (RNAi) application in the free-living nematode Caenorhabditis elegans, the exploitation of this powerful technique to helminths parasites with complex life-cycle has been a challenge for parasitologists. It has proved to be effective only for certain parasite species and specific target genes. To date, RNAi is the only methodology available for reverse genetics in trematodes and combined to rescue studies (such heterologous complementation) have been the on… Show more
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