RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate

Bountali, Aikaterini; Tonge, Daniel; Mourtada-Maarabouni, Mirna

doi:10.1016/j.ijbiomac.2019.03.005

Cited by 34 publications

(38 citation statements)

References 55 publications

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“…CASC15‐S has already been found to be a tumor suppressor in NB as mentioned above, 20 which is consistent with our findings. MIAT (Myocardial Infarction Associated Transcript) has recently been found to possess tumor‐promoting properties in glioblastoma and NB, which is contrary to our findings and need further investigation 33 . The rest of the other lncRNAs identified in this study have not been reported to be associated with NB before.…”

Section: Discussioncontrasting

confidence: 99%

Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma

et al. 2020

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Background:The association between long noncoding RNAs (lncRNAs) and spontaneous regression of neuroblastoma (NB) has rarely been investigated and remains unknown. Objective: To identify prognostic lncRNAs involved in the spontaneous regression of NB. Methods: Differential expression analyses were performed between those samples with an outcome of death in stage 4 NB group and those samples with an outcome of survival in stage 4S NB group in two independent public datasets, respectively.Univariate Cox proportional hazard regression survival analysis was performed in each of the entire cohort to identify those lncRNAs significantly associated with overall survival (OS). Those lncRNAs independently associated with OS were then identified by multivariate Cox survival analysis and used to construct an lncRNA risk score. Results: A total of 20 differentially expressed and survival-related lncRNAs were identified sharing between the two independent cohorts. The expression of each of these 20 lncRNAs was significantly correlated with the expression of NTRK1, which is a wellknown factor involved in NB spontaneous regression. Four lncRNAs (LNC00839, FIRRE, LOC283177, and LOC101928100) were identified to be significantly associated with survival independent with each other and a four-lncRNA signature risk score was constructed. Patients with high lncRNA signature risk score had a significantly poorer OS and event-free survival than those with low lncRNA signature risk score. The four-lncRNA signature has a good performance in predicting survival independent with MYCN amplification (nonamplified vs amplified), age status (<18 months vs ≥18 months), risk status (low risk vs high risk), and International Neuroblastoma Staging System (INSS) stage (INSS 1/2/3/4S vs INSS 4). Conclusions: We identified 20 survival-related lncRNAs that might be associated with the spontaneous regression of NB and developed a four-lncRNA signature risk score. The four-lncRNA signature is an independent prognostic factor for survival of NB patients. | 3801 MENG Et al.

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Section: Discussioncontrasting

confidence: 99%

Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma

et al. 2020

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“…Knockdown of lncRNA myocardial infarction associated transcript (MIAT) reduces cell growth and migration, and enhances apoptosis in NB cell line when compared with that in control [386]. Atmadibrata et al reported that linc00467 can increase cell viability and reduce apoptosis and cell cycle arrest in NB cells via suppressing DKK1 expression [387].…”

Section: Lncrnas In Neuroblastoma (Nb)mentioning

confidence: 99%

Long Non-Coding RNA in the Pathogenesis of Cancers

Chi

Wang

et al. 2019

Cells

645

452

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The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, and targeted drugs, their effectiveness is still limited. The overall survival rate of malignant cancers is still low. It is necessary to further study the mechanisms for malignant cancers, and explore new biomarkers and targets that are more sensitive and effective for early diagnosis, treatment, and prognosis of cancers than traditional biomarkers and methods. Long non-coding RNAs (lncRNAs) are a class of RNA transcripts with a length greater than 200 nucleotides. Generally, lncRNAs are not capable of encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions and functions at transcriptional, translational, and post-translational levels. In the past decade, it has been demonstrated that the dysregulated lncRNA profile is widely involved in the pathogenesis of many diseases, including cancer, metabolic disorders, and cardiovascular diseases. In particular, lncRNAs have been revealed to play an important role in tumor growth and metastasis. Many lncRNAs have been shown to be potential biomarkers and targets for the diagnosis and treatment of cancers. This review aims to briefly discuss the latest findings regarding the roles and mechanisms of some important lncRNAs in the pathogenesis of certain malignant cancers, including lung, breast, liver, and colorectal cancers, as well as hematological malignancies and neuroblastoma.

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“…Large quantities of studies have highlighted the role of lncRNAs in carcinomas. 5,[14][15][16] SNHG7 has been well-accepted as an oncogenic lncRNA in various carcinomas. 7,[17][18][19] In our study, we found that SNHG7 was upregulated in TC cells.…”

Section: Discussionmentioning

confidence: 99%

The function of SNHG7/miR‐449a/ACSL1 axis in thyroid cancer

Guo

Gao

et al. 2020

J of Cellular Biochemistry

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Thyroid cancer (TC) has been characterized as the most common malignant malady of the endocrine system. Small nucleolar RNA host gene 7 (SNHG7) has been reported to serve as a key regulator in a large number of human cancer types, but its role in TC and the underlying regulatory mechanism have never been evaluated yet. The present study indicated that the expression of SNHG7 was markedly higher in TC cell lines. Knockdown of SNHG7 led to a suppression of TC cell progression and migration. Acyl‐CoA synthetase long‐chain family member 1 (ACSL1) has also been demonstrated as an oncogene in many cancers. Herein an inhibition of ACSL1 after SNHG7 knockdown was captured. Further, the suppressing effects of SNHG7 knockdown on TC cell processes were counteracted by ACSL1 overexpression. Data from online bioinformatics analysis, RNA immunoprecipitation, and luciferase reporter assays validated the interaction between microRNA‐449a (miR‐449a) and SNHG7 or ACSL1. It was also verified that SNHG7 sequestered miR‐449a and therefore elevated ACSL1 expression levels. To conclude, the current study indicated that SNHG7 promoted proliferation and migration of TC cells by sponging miR‐449a and therefore upregulating ACSL1. The present study may provide more explorations about the molecular regulation mechanism of long noncoding RNAs in TC progression.

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RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate

Cited by 34 publications

References 55 publications

Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma

Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma

Long Non-Coding RNA in the Pathogenesis of Cancers

The function of SNHG7/miR‐449a/ACSL1 axis in thyroid cancer

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