RNA Versus Protein, How Structure Influences Targeting, a New Challenge for Drug Discovery

Bonetti, Alessandro; Lacroix, Aurélie; Walsh, Emma; Ghidini, Alice

doi:10.1007/978-3-031-36390-0_6

RNA Technologies

2023

DOI: 10.1007/978-3-031-36390-0_6

|View full text |Cite

RNA Versus Protein, How Structure Influences Targeting, a New Challenge for Drug Discovery

Alessandro Bonetti,

Aurélie Lacroix,

Emma Walsh

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

RNA-Binding Small Molecules in Drug Discovery and Delivery: An Overview from Fundamentals

Chen,

Mao,

Cheng

et al. 2024

J. Med. Chem.

View full text Add to dashboard Cite

RNA molecules, similar to proteins, fold into complex structures to confer diverse functions in cells. The intertwining of functions with RNA structures offers a new therapeutic opportunity for small molecules to bind and manipulate disease-relevant RNA pathways, thus creating a therapeutic realm of RNA-binding small molecules. The ongoing interest in RNA targeting and subsequent screening campaigns have led to the identification of numerous compounds that can regulate RNAs from splicing, degradation to malfunctions, with therapeutic benefits for a variety of diseases. Moreover, along with the rise of RNA-based therapeutics, RNA-binding small molecules have expanded their application to the modification, regulation, and delivery of RNA drugs, leading to the burgeoning interest in this field. This Perspective overviews the emerging roles of RNAbinding small molecules in drug discovery and delivery, covering aspects from their action fundamentals to therapeutic applications, which may inspire researchers to advance the field. ■ SIGNIFICANCEThis Perspective explores the principles of RNA structures and their interaction modes with small molecules. It also discusses some exciting RNA-binding small molecules along with emerging conjugates such as RiboTAC for targeted RNA degradation. A focus is placed on RNA-binding small molecules in drug delivery, in which their applications in siRNA delivery and gene circuit therapy are covered. Altogether this provides a new insight to the roles of RNA-binding small molecules in drug development.

show abstract

RNA-Binding Small Molecules in Drug Discovery and Delivery: An Overview from Fundamentals

Chen,

Mao,

Cheng

et al. 2024

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

RNA Versus Protein, How Structure Influences Targeting, a New Challenge for Drug Discovery

Cited by 1 publication

References 98 publications

RNA-Binding Small Molecules in Drug Discovery and Delivery: An Overview from Fundamentals

RNA-Binding Small Molecules in Drug Discovery and Delivery: An Overview from Fundamentals

Contact Info

Product

Resources

About