RNF6 as an Oncogene and Potential Therapeutic Target—A Review

Abstract

The RNF6 gene encodes Ring Finger Protein 6 (RNF6), which functions as a ubiquitin ligase. Its functions are not entirely known, but research shows that it is involved in human cancer development. Initially, this gene was considered to be a tumor suppressor. Numerous statistical analyses on cell lines and animals indicate, however, that RNF6 functions as an oncogene, involved in signaling pathways, including SHP1/STAT3, AKT/mTOR, Wnt/β-catenin, or ERα/Bcl-xL. Due to this fact, it has become a potential prognostic factor and therapeutic target. Studies in tumor cells and model organisms using inhibitors such as total saponins from Paris forrestii (TSPf), ellagic acid, or microRNA molecules show the effectiveness of inhibiting RNF6, and through it, the pathways of tumor cell proliferation. The results of the currently available studies are promising, but the function of RNF6 is not fully understood. More research is needed to assess the role of RNF6 and to check the safety and efficacy of inhibitors.

Deletion of the RNF6 gene in a patient with epileptic encephalopathy – a case report and literature review

“…As a ubiqui tin ligase, RNF6 is primarily associated with polyubiquiti nation and degradation of other proteins [13,14]. So far, research on this protein has focused mainly on its role in cancer [4,[15][16][17][18].…”

“…The RNF6 (Ring Finger Protein 6) gene, located on 13q12.13, encodes a zinc finger domain protein that acts as an E3 ubiquitin ligase. So far, abnormalities in this gene have been associated mainly with the development of tu mours [4]. The aim of the study is to draw attention to the chromosomal abnormality in a 3.5yearold girl, ascertain its possible impact on the clinical features, and consider the expression of the RNF6 gene as a possible aetiological factor of seizure disorders in children.…”

RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma via JAK2/STAT3 Signaling Pathway

“…RNF6 is an E3 ubiquitin ligase and increasing evidence has indicated that RNF6 is involved in the development of various cancers (7,8,12,23,24). As a ubiquitin ligase, RNF6 regulates numerous cellular processes by ubiquitin-dependent degradation of target proteins (25).…”

Recent Developments in Search of Effective Herbal Medicine for The Treatment of Leukemia

“…expression was significantly negatively correlated to the survival rate of AML patients [41]. The downregulation of RNF6 was linked to AKT/mTOR signaling inactivation by total saponins from Paris forrestii [38].…”