2023
DOI: 10.21203/rs.3.rs-3309460/v1
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RNNHC: A hybrid error correction algorithm for long reads based on Recurrent Neural Network

Rongshu Wang,
Jianhua Chen

Abstract: Long reads generated by third-generation sequencing technologies show irreplaceable advantages in downstream analysis by virtue of their ultra-long read lengths. However, their high error rate also affects the accuracy of downstream analysis. Meanwhile, deep learning has shown its talents in the processing of long gene sequence problems. In this work, a hybrid error correction algorithm is proposed, which uses the idea of processing multi-class tasks with a recurrent neural network to capture the long-term dep… Show more

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