Roadmap on wavefront shaping and deep imaging in complex media

Gigan, Sylvain; Katz, Ori; Aguiar, Hilton B. de; Andresen, Esben Ravn; Aubry, Alexandre; Bertolotti, Jacopo; Bossy, Emmanuel; Bouchet, Dorian; Brake, Joshua; Brasselet, Sophie; Bromberg, Yaron; Cao, Hui; Chaigne, Thomas; Cheng, Zhongtao; Choi, Wonshik; Čižmár, Tomáš; Cui, Meng; Curtis, Vincent R.; Defienne, Hugo; Hofer, Matthias; Horisaki, Ryoichi; Horstmeyer, Roarke; Ji, Na; LaViolette, Aaron K.; Mertz, Jérôme; Moser, Christophe; Mosk, Allard; Pégard, Nicolas C.; Piestun, Rafael; Popoff, Sébastien M.; Phillips, David B.; Psaltis, Demetri; Rahmani, Babak; Rigneault, Hervé; Rotter, Stefan; Tian, Lei; Vellekoop, Ivo M.; Waller, Laura; Wang, Lihong; Weber, T.; Xiao, Sheng; Xu, Chris; Yamilov, Alexey; Yang, Changhuei; Yılmaz, Hasan

doi:10.1088/2515-7647/ac76f9

Cited by 97 publications

(71 citation statements)

References 245 publications

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“…As only a fraction of the light is able to pass through the scattering medium and reach the camera, one risks having to take the difference between two small signals. Therefore, sensitive and fast detectors with a good dynamic range will be required for real-world applications 39 .…”

Section: Discussionmentioning

confidence: 99%

Tracking moving objects through scattering media via speckle correlations

2022

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Scattering can rapidly degrade our ability to form an optical image, to the point where only speckle-like patterns can be measured. Truly non-invasive imaging through a strongly scattering obstacle is difficult, and usually reliant on a computationally intensive numerical reconstruction. In this work we show that, by combining the cross-correlations of the measured speckle pattern at different times, it is possible to track a moving object with minimal computational effort and over a large field of view.

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Section: Discussionmentioning

confidence: 99%

Tracking moving objects through scattering media via speckle correlations

2022

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“…Finally, it is necessary to develop advanced AO techniques that can efficiently control higher-order multiple scattering for more dramatic improvements in imaging depth. It is generally accepted that focusing light beyond one transport mean free path (~ 1 mm in biological tissues), i.e., where the propagation direction of waves has been totally scrambled, is infeasible [3,7]. Until now, AO methods have primarily relied on the use of singly-scattered and forward multiply-scattered waves to focus light or inside a specimen.…”

Section: Discussionmentioning

confidence: 99%

“…9c. The field-of-view is 128 × 128 × 120 μm 3 Indirect wavefront sensing method can also be integrated with SIM [42]. In the image-based sensorless AO (IsoSense), Zernike polynomials were used as a standard basis for correction of sample-induced aberration.…”

Section: Indirect Wavefront Sensing For Ao Fluorescence Imagingmentioning

confidence: 99%

“…Specifically, it can provide precise subcellular and molecular information with high resolution at the wavelength level with minimal hazard. However, the imaging depth accessible by optical imaging is shallow, and the spatial resolution rapidly degrades along with the axial depth since the propagation of light waves significantly deteriorates within the biological tissues by specimen-induced aberrations and multiple light scattering [3,4]. Therefore, signal attenuation and limitations in imaging depth caused by wave distortion have been important issues in diverse fields of biophotonics over the past decades.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in optical imaging through deep tissue: imaging probes and techniques

et al. 2022

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Optical imaging has been essential for scientific observations to date, however its biomedical applications has been restricted due to its poor penetration through tissues. In living tissue, signal attenuation and limited imaging depth caused by the wave distortion occur because of scattering and absorption of light by various molecules including hemoglobin, pigments, and water. To overcome this, methodologies have been proposed in the various fields, which can be mainly categorized into two stategies: developing new imaging probes and optical techniques. For example, imaging probes with long wavelength like NIR-II region are advantageous in tissue penetration. Bioluminescence and chemiluminescence can generate light without excitation, minimizing background signals. Afterglow imaging also has high a signal-to-background ratio because excitation light is off during imaging. Methodologies of adaptive optics (AO) and studies of complex media have been established and have produced various techniques such as direct wavefront sensing to rapidly measure and correct the wave distortion and indirect wavefront sensing involving modal and zonal methods to correct complex aberrations. Matrix-based approaches have been used to correct the high-order optical modes by numerical post-processing without any hardware feedback. These newly developed imaging probes and optical techniques enable successful optical imaging through deep tissue. In this review, we discuss recent advances for multi-scale optical imaging within deep tissue, which can provide reseachers multi-disciplinary understanding and broad perspectives in diverse fields including biophotonics for the purpose of translational medicine and convergence science. Graphical Abstract Methodologies for multi-scale optical imaging within deep tissues are discussed in diverse fields including biophotonics for the purpose of translational medicine and convergence science. Recent imaging probes have tried deep tissue imaging by NIR-II imaging, bioluminescence, chemiluminescence, and afterglow imaging. Optical techniques including direct/indirect and coherence-gated wavefront sensing also can increase imaging depth.

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“…While prior wavefront shaping methods can overcome such effects to focus within thick tissue at high speeds, [ 8–10 ] significant engineering challenges remain to achieve deep‐tissue imaging in human subjects. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection

Xu¹,

Yang²,

Liu³

et al. 2022

Advanced Science

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Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep-tissue video reconstruction of decorrelation dynamics. In this work, a single-photon avalanche diode array camera is utilized to simultaneously monitor the temporal dynamics of speckle fluctuations at the single-photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. Then a deep neural network is applied to convert the acquired single-photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. The ability to reconstruct images of transient (0.1-0.4 s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter-scale resolution is demonstrated, and it is highlighted how the model can flexibly extend to monitor flow speed within buried phantom vessels.

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Roadmap on wavefront shaping and deep imaging in complex media

Cited by 97 publications

References 245 publications

Tracking moving objects through scattering media via speckle correlations

Tracking moving objects through scattering media via speckle correlations

Recent advances in optical imaging through deep tissue: imaging probes and techniques

Imaging Dynamics Beneath Turbid Media via Parallelized Single‐Photon Detection

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