“…Fractional anisotropy (FA) maps obtained by DTI analysis showed loss of WM integrity in the ipsilateral hemisphere (in the internal capsule and corpus callosum) [ 16 , 240 ] in a pig model of stroke. In addition, a stem cell vesicle-based treatment was found to preserve the integrity and functionality of WM [ 103 , 104 ].When focusing on the effects of hemorrhagic stroke, leakage of blood into the brain parenchyma of swine has been mostly measured using CT [ 180 , 206 , 208 , 214 ] or MRI FLAIR images or in T2*-weighted images [ 165 , 173 , 174 , 178 , 187 , 213 , 214 , 241 ]. To overcome possible artefacts, the iron from hemoglobin can be indirectly measured using the rate of transverse magnetization relaxation, R2*(1/T2*).…”