Robotic-Assisted Surgery for Upper Tract Urothelial Carcinoma: A Comparative Survival Analysis

Clements, Matthew; Krupski, Tracey L.; Culp, Stephen H.

doi:10.1245/s10434-018-6557-8

Cited by 39 publications

(22 citation statements)

References 24 publications

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“…Radical nephroureterectomy can be performed with open techniques as well as laparoscopically +/- robot-assisted with similar oncological and safety outcomes ( 49 , 50 ). The time of lymph node excision can independently be performed laparoscopically or through an open technique.…”

Section: Methodsmentioning

confidence: 99%

Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review

et al. 2022

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Although lymphonodal dissection is well-accepted for muscle-invasive bladder cancer management, its role is still debated during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). The aim of this study was to summarize the current knowledge concerning the indication, anatomical template, prognostic, and therapeutic roles of lymph node dissection (LND) performed at the time of RNU. Quality control markers, such as the number of lymph nodes (LN) removed, lymph node density, and safety of the different surgical approaches, were assessed. We performed a narrative review using the PubMed and ClinicalTrials.gov databases. We identified and analyzed articles based on the practice and the role of lymph node dissection for non-metastatic UTUC. There are no clear guidelines regarding the indication of LND for UTUC, but aggressive tumors may beneficiate from lymphadenectomy since lymph node invasion is a clear independent poor prognostic factor, allowing for adjuvant treatments. It seems that an extended lymphadenectomy may provide therapeutic advantages as a higher number of nodes removed may be related to the removal of undetected LNs micrometastases and a subsequent improvement in recurrence rate and cancer-specific survival. Clear anatomical templates are thus needed based on the location and the laterality of the primary tumor.

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Section: Methodsmentioning

confidence: 99%

Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review

et al. 2022

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“…The standard of care for high-risk carcinomas is RNU, with an open [ 39 ], laparoscopic [ 75 , 76 ] or robotic approach [ 77 , 78 ]. On the contrary, in patients with a solitary kidney and/or impaired renal function, kidney-sparing management should be considered on a case-by-case basis [ 79 ].…”

Section: Treatment Managementmentioning

confidence: 99%

MicroRNA Signatures in the Upper Urinary Tract Urothelial Carcinoma Scenario: Ready for the Game Changer?

Cinque

Capasso

Vago

et al. 2022

IJMS

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Upper urinary tract urothelial carcinoma (UTUC) represents a minor subgroup of malignancies arising in the urothelium of the renal pelvis or ureter. The estimated annual incidence is around 2 cases per 100,000 people, with a mean age at diagnosis of 73 years. UTUC is more frequently diagnosed in an invasive or metastatic stage. However, even though the incidence of UTUC is not high, UTUC tends to be aggressive and rapidly progressing with a poor prognosis in some patients. A significant challenge in UTUC is ensuring accurate and timely diagnosis, which is complicated by the non-specific nature of symptoms seen at the onset of disease. Moreover, there is a lack of biomarkers capable of identifying the early presence of the malignancy and guide-tailored medical treatment. However, the growing understanding of the molecular biology underlying UTUC has led to the discovery of promising new biomarkers. Among these biomarkers, there is a class of small non-coding RNA biomarkers known as microRNAs (miRNAs) that are particularly promising. In this review, we will analyze the main characteristics of UTUC and focus on microRNAs as possible novel tools that could enter clinical practice in order to optimize the current diagnostic and prognostic algorithm.

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“…However, the development of minimally invasive nephroureterectomies has led to greater use of laparoscopic or robot-assisted nephroureterectomy. 26 Given the widespread use of RNU procedures in low grade UTUC, there is growing interest in determining the costs and health care use incurred by RNU procedures. 10,19e26 Nine observational and population based studies evaluated total up-front treatment costs and health care use (length of stay or operative time) associated with RNU procedures, which are summarized in the supplementary table (https:// www.urologypracticejournal.com).…”

Section: Burden Of Radical Utuc Interventionsmentioning

confidence: 99%

“…10,22,23,25 Total hospital charges ranged from $33,054 to $53,869 for ONU, $36,596 to $50,596 for LNU and $49,791 to $63,186 for RANU. 21,26 The primary cost drivers behind the total direct cost per patient were supply costs and operating room costs. 10 Tinay et al reported results from a population based study that evaluated use trends and costs associated with ONU (17,254 patients), LNU (13,317) and RANU (3,774) in patients with diagnoses of renal pelvis or ureteric neoplasms from 2004 to 2013, using the Premier Hospital Database.…”

Section: Burden Of Radical Utuc Interventionsmentioning

confidence: 99%

Understanding the Economic Burden of Treating Low-Grade Upper Tract Urothelial Cancer in the United States

Thacker¹,

Raman

McLean

et al. 2021

Urology Practice

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Introduction: Low grade upper tract urothelial cancer is an uncommon urothelial tumor for which treatment involves multiple ureteroscopic interventions and potentially radical nephroureterectomy. Given the burden of these procedures, there is growing interest in determining how the utilization, complications and morbidities associated with treatment contribute to the burden of care for upper tract urothelial cancer. The aim of this study was to conduct a systematic literature review to understand the economic burden of treating low grade upper tract urothelial cancer.

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Robotic-Assisted Surgery for Upper Tract Urothelial Carcinoma: A Comparative Survival Analysis

Cited by 39 publications

References 24 publications

Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review

Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review

MicroRNA Signatures in the Upper Urinary Tract Urothelial Carcinoma Scenario: Ready for the Game Changer?

Understanding the Economic Burden of Treating Low-Grade Upper Tract Urothelial Cancer in the United States

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