2016
DOI: 10.1016/j.bmc.2016.07.023
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Robust design of some selective matrix metalloproteinase-2 inhibitors over matrix metalloproteinase-9 through in silico/fragment-based lead identification and de novo lead modification: Syntheses and biological assays

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Cited by 51 publications
(24 citation statements)
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“…Moreover, the association of biphenyl function with the ring aromatic features of pharmacophore mapping suggests that the ring aromaticity may play important roles in higher MMP‐2 inhibition. The structure‐based contour map of the most potent compound (Cpd 48 ) also justify these observations (Figure ).…”
Section: Resultssupporting
confidence: 52%
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“…Moreover, the association of biphenyl function with the ring aromatic features of pharmacophore mapping suggests that the ring aromaticity may play important roles in higher MMP‐2 inhibition. The structure‐based contour map of the most potent compound (Cpd 48 ) also justify these observations (Figure ).…”
Section: Resultssupporting
confidence: 52%
“…Therefore, designing potent and selective MMP‐2 inhibitors is still in demand to combat the dreaded disease cancer. Though several alignment‐based 3D‐QSAR studies were performed earlier on different MMP‐2 inhibitors, none of these highlighted any robust alignment dependent QSARs . Zheng et al .…”
Section: Introductionmentioning
confidence: 99%
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