Robust Hydroxyapatite Coating by Laser‐Induced Hydrothermal Synthesis

Abstract

Owing to enhanced biocompatibility and osseointegration, hydroxyapatite (HAp) coatings are often applied to biomedical devices that are implanted directly on the bone. Although various HAp coating techniques have been developed, they are restricted due to the time-consuming HAp synthesis and additional coating processes. Herein, the development of a rapid single-step method for simultaneous synthesis and coating of HAp via nanosecond laser surface treatment is described. In the conventional HAp-coating method, the resulting interface between the HAp layer and the base material is clearly distinguished. However, in this method, HAp synthesis and coating occur simultaneously via the melting of the base material (i.e., titanium, polyetheretherketone, and polycaprolactone) to form a gradient HAp-base material composite coating layer. The resultant coating layer on a titanium surface exhibits a binding force of 31.7-47.2 N, which is sufficient for medical implant applications. Changing the laser irradiation conditions provides quantitative adjustment of the HAp formation process and coating layer thickness. Furthermore, the resulting HAp coating layer better facilitates the attachment of bone cells. These results offer a breakthrough in the surface treatment of bone-bonding sites of metal and polymer biomedical devices.

Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning

“…HA-coated on the titanium surface used in this study has a Ca/P ratio of 1.67 and has relatively low crystallinity [ 37 ]. Although it is known that the Ca/P ratio and crystallinity of HA affect the adhesion and growth of bone cells [ 58 , 59 ], this study studied the behavior of cells in the area where HA was removed through CMH.…”

“…By allowing different materials to be exposed together, this technique affords a topographical effect and simultaneously provides the benefits from the exposure of two different material surfaces. We applied and developed the results of our existing research that can coat HA using a nanosecond laser [ 37 ] to form various types of HA patterns. This new technique promotes and controls cell migration while maintaining the advantages of the existing apatite, and it is applicable to all areas where such apatite is used.…”

Citric Acid-Mediated Microwave-Hydrothermal Synthesis of Mesoporous F-Doped HAp Nanorods from Bio-Waste for Biocidal Implant Applications

“…[ 3 ]. HAp is the most widely used material for different biomedical applications, such as dermal filler [ 4 ], wound healing [ 5 ], scaffolds [ 6 , 7 , 8 ], biomedical coating [ 9 ], tissue engineering [ 10 ], and bone regeneration application [ 11 , 12 ]. Even though HAp is widely used, its usage for surgical purposes in implantation is limited due to bacterial infection.…”

Improvement of Yttrium Oxyfluoride Coating with Modified Precursor Solution for Laser-Induced Hydrothermal Synthesis

“…Recently, our group developed a technology for synthesizing and coating ceramic materials using laser heat treatment [24]. The laser-induced single-step coating (LISSC) technology offers numerous advantages, because it allows coating at the same time as particle synthesis [25][26][27].…”