Robust ICG Theranostic Nanoparticles for Folate Targeted Cancer Imaging and Highly Effective Photothermal Therapy

Zheng, Mingbin; Zhao, Pengfei; Luo, Zhenyu; Gong, Ping; Zheng, Cuifang; Zhang, Pengfei; Yue, Caixia; Gao, Duyang; Ma, Yifan; Cai, Lintao

doi:10.1021/am5004393

Cited by 238 publications

(206 citation statements)

References 34 publications

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“…Indocyanine dyes having an absorbance in NIR range around 800 nm have been widely used as photothermal agents. The most commonly used Indocyanine dye is the Indocyanine Green (ICG) which has been explored for multimodal imaging and photothermal agent [20][21][22][23]. The poor aqueous solubility, short half-life and photobleaching properties of ICG limit its use as a good photothermal agent.…”

Section: Introductionmentioning

confidence: 99%

IR 820 dye encapsulated in polycaprolactone glycol chitosan: Poloxamer blend nanoparticles for photo immunotherapy for breast cancer

Kumar

Srivastava

2015

Materials Science and Engineering: C

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In the present study, we have fabricated biocompatible and biodegradable monodisperse IR 820 encapsulated polycaprolactone (PCL) glycol chitosan (GC): Poloxamer blend nanoparticles (PP-IR NPs) for imaging and effective photo-immunotherapy. IR 820 has been used as an imaging and photothermal agent whereas glycol chitosan (GC) as an immunostimulatory agent. The combination of IR 820, poloxamer, and GC can be used effectively for photoimmunotherapy for cancer, drug-resistant and TNF-α resistant estrogen positive breast cancer. PP-IR NPs are stable in aqueous solution. The uniform size of 100-220 nm with a high zeta value of +38 ± 2 mV led them to accumulate in cancer cells. Laser treatment did not affect the morphology of PP-IR NPs as observed under the transmission electron microscope (TEM). In vitro cytotoxicity studies on MCF-7 cells showed enhanced toxicity upon laser treatment. Further, we validated the cell death by reactive oxygen species (ROS) production. Our studies thus showed that PP-IR NPs are effective in suppressing metastatic cancer as the combinational therapy leads to the formation of apoptotic bodies in MCF-7 cells.

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Section: Introductionmentioning

confidence: 99%

IR 820 dye encapsulated in polycaprolactone glycol chitosan: Poloxamer blend nanoparticles for photo immunotherapy for breast cancer

Kumar

Srivastava

2015

Materials Science and Engineering: C

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“…48 These results demonstrate the high internalization of FA-RIPNPs, with excellent positive targeting capabilities by U87 cells.…”

mentioning

confidence: 67%

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

Xin

Yang

2016

IJN

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“…To overcome these limitations, many nanocomplexes, such as micelles self-assembled from amphiphilic polymers, containing NIR dyes have therefore been developed as photothermal nano-agents for cancer treatment. For example, ICG-containing nanostructures self-assembled with phospholipidpolyethylene glycol (PL-PEG) showed much better stability than free ICG [24,48,49]. Irradiation of tumors by an 808-nm laser after intravenous (i.v.)…”

Section: Nir Dye-containing Micellesmentioning

confidence: 99%

Recent advances in the development of organic photothermal nano-agents

2014

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Recently, photothermal therapy (PTT) has attracted tremendous attention because of its high efficacy in tumor ablation and minimal damage to normal tissues. While many inorganic nanomaterials, especially various gold nanostructures and nanocarbons, have been extensively explored for near-infrared (NIR) light triggered PTT in the past decade, a variety of organic photothermal agents have also emerged in recent years, aiming at replacing their inorganic counterparts which usually are not biodegradable. In this mini-review, we will summarize several typical classes of recently developed NIR-absorbing organic PTT nanoagents, which include NIR dye-containing micelles, porphysomes, protein-based agents, conjugated polymers, and organic/inorganic nanocomposites. The development of imaging-guided PTT and combination therapy will be introduced as well. Finally, the perspectives and challenges in the future development of PTT will be discussed.

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Robust ICG Theranostic Nanoparticles for Folate Targeted Cancer Imaging and Highly Effective Photothermal Therapy

Cited by 238 publications

References 34 publications

IR 820 dye encapsulated in polycaprolactone glycol chitosan: Poloxamer blend nanoparticles for photo immunotherapy for breast cancer

IR 820 dye encapsulated in polycaprolactone glycol chitosan: Poloxamer blend nanoparticles for photo immunotherapy for breast cancer

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

Recent advances in the development of organic photothermal nano-agents

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