2023
DOI: 10.21203/rs.3.rs-2797422/v1
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Robust immunogenic potential of N and C-terminal deleted variant of dengue virus NS1 protein (dNS1)

Abstract: NS1 is an elusive dengue protein which assists in viral replication, assembly, pathogenesis, and immune evasion. It is secreted in blood plasma, where its levels are positively related to disease severity. It interacts with immune receptors and endothelial cells and triggers the production of inflammatory cytokines leading to severe clinical implications like thrombocytopenia, hemorrhage, and vascular leakage. Despite its pathogenic roles, NS1 is being used in various vaccine formulations due to its sequence c… Show more

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