Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction

Vermeij, T.A.C.; Edelbroek, Peter M.

doi:10.1016/j.jchromb.2007.06.023

Cited by 91 publications

(71 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Multiple analytical methodologies have been reported for the measurement of 10-hydroxycarbazepine in plasma/serum including GC [129], GC/MS [130], HPLC [131,132], LC/MS [133], LC/MS/MS [134] and micellar electrokinetic chromatography [135]. TDM is justified when changes are expected that might alter 10-hydroxycarbazepine clearance including changes in renal function, pregnancy, and concomitant use of liver enzyme-inducing drugs.…”

Section: Oxcarbazepinementioning

confidence: 99%

Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications

Krasowski

2010

Pharmaceuticals

View full text Add to dashboard Cite

In the past twenty years, 14 new antiepileptic drugs have been approved for use in the United States and/or Europe. These drugs are eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, rufinamide, stiripentol, tiagabine, topiramate, vigabatrin and zonisamide. In general, the clinical utility of therapeutic drug monitoring has not been established in clinical trials for these new anticonvulsants, and clear guidelines for drug monitoring have yet to be defined. The antiepileptic drugs with the strongest justifications for drug monitoring are lamotrigine, oxcarbazepine, stiripentol, and zonisamide. Stiripentol and tiagabine are strongly protein bound and are candidates for free drug monitoring. Therapeutic drug monitoring has lower utility for gabapentin, pregabalin, and vigabatrin. Measurement of salivary drug concentrations has potential utility for therapeutic drug monitoring of lamotrigine, levetiracetam, and topiramate. Therapeutic drug monitoring of the new antiepileptic drugs will be discussed in managing patients with epilepsy.

show abstract

Section: Oxcarbazepinementioning

confidence: 99%

Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications

Krasowski

2010

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…There are some indications that phenytoin has other effects, including anxiety control and mood stabilization, although it has never been approved for those purposes by the FDA [1]. sodium Several methods have been reported for the determination of phenytoin sodium using HPLC [2][3][4][5][6][7], LC-MS [8,9], GC [10][11][12], spectrophotometry [13,14], capillary zone electrophoresis [15], polarography [16], potentiometry [17]. This work describes two different implementation of a new and selective type of membrane sensors: plastic membrane and coated wire electrodes for the determination of phenytoin sodium in pure solutions, pharmaceutical preparations and biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Construction of different types of ion-selective electrodes and validation of direct potentiometric determination of phenytoin sodium

et al. 2010

View full text Add to dashboard Cite

Abstract:The construction and performance characteristics of phenytoin sodium selective electrodes are detailed. Two types of electrodes:plastic membrane I and coated wire II, were constructed based on the incorporation of phenytoin sodium with tungstosilicic acid. -6 M with a detection limit 1.3×10 -6 M and 2.5×10 -7 M for electrode I and II, respectively. The electrodes gave average selective precision and were usable within the pH range 6-10. Interference studies from common cations, alkaloids, sugars, amino acids and drug excipients are reported. The results obtained by the proposed electrodes were also applied successfully for the determination of the drug in pharmaceutical preparations and biological fluids.

show abstract

“…Most common method for LMT analysis in biological fluids is HPLC procedures with UV detection and short run times within 2 min can be easily obtained on regular columns. Setting of UV detector to wavelength of about 310 nm allows a high specificity of detection because all other AEDs and their metabolites are UV-transparent at this wavelength with very few exceptions [76,170,171]. Assays developed over past 15 years have focus more on separating older and newer AEDs [64].…”

Section: Lamotrigine (Lmt)mentioning

confidence: 99%