Once the concept of chiral molecules was proposed, the task of chiral resolution has accompanied around in the related area. Naturally, scientists need fast and accurate methods to distinguish different chiralities. Here, we show a feasible method based on non-adiabatic holonomic quantum computation (NHQC), which can achieve over 99% discrimination of different chiralities. Based on the original scheme, we studied the modified version, NHQC+. The experimental data proved that it has better robustness than the original protocol, indicating a promising development in the relevant fields.