With the increasing frequency of emergencies in recent years, the emergency response capacity of the emergency management system needs to be improved. Based on safety stock strategy, this paper proposes a multilevel siting model on the topic of mobile emergency response. We modeled the emergency response needs during emergencies by incorporating the population distribution of each region. The uncertainty of emergencies is modeled by aggregating the frequency of crises in each region over the past 20 years. The site selection model minimizes contingency logistics costs that include transshipment, deployment, inventory, and safety stock costs. In this paper, the IA (Immune Algorithm) is optimized to solve the constructed emergency site selection model. The experiments on the model were carried out with data from the area of Chongqing, Sichuan Province. The number of logistics centers and distribution storage warehouses was tested. The influence of safety stock strategy on the total cost of emergency logistics was analyzed. The research results found that the cost of safety stock is negatively related to the cost of transshipment. In addition, the total cost of emergency logistics has a lower bound. Adding distribution and storage warehouses does not further reduce the total emergency logistics cost.