Robustness evaluation of Intensity Modulated Proton Therapy plans using Dose Volume Population Histogram

Accurate assessment of a Dutch practical robustness evaluation protocol in clinical PT with pencil beam scanning for neurological tumors

“…It has, however, two limitations: (i) the error scenarios are fixed and limited in their number while the actual errors follow continuous distributions and (ii) it does not address systematic and random geometrical errors separately, which are different for each treatment and for each fraction. A priori, it remains uncertain how the clinical robustness settings relate to the actual patient errors, and it is not guaranteed that this approach leads to adequate robustness in treatment planning [19][20][21]. Furthermore, it is unclear what is the impact of a VWmin CTV underdose with the current clinical protocol.…”

Evaluation of alternative parameter settings for dose restoration and full plan adaptation in IMPT for prostate cancer

“…Intensity-modulated proton therapy (IMPT) is highly sensitive to anatomical variations, which can cause differences between the planned and delivered doses. A result of this can be insufficient target coverage during the course of treatment [1][2][3][4]. An approach to account for these anatomical variations, ensuring adequate target coverage in all treatment fractions while keeping the doses to the OARs acceptable, is to use adaptive treatment planning.…”