Rocuronium Bromide in Dental Day Case Anaesthesia—A Comparison with Atracurium and Vecuronium

Chetty, M. S.; Pollard, Brian; Wilson, A.; Healy, T.E.J.

doi:10.1177/0310057x9502300108

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…The results of these studies compares well with the results of the present study. The quality of intubating conditions at the point of successful intubation was also rated better after Rocuronium than with Vecuronium and Atracurium, which matched with the results demonstrated in previous investigations in adults [37]. Vecuronium tended to be superior also to Atracurium, but this difference was not considered statistically significant.…”

Section: Group a (N=50)supporting

confidence: 85%

Quality of Laryngoscopic View and Rapidity of Development of Intubating Conditions after Atracurium, Vecuronium and Rocuronium: A Randomized Controlled Study

Mitra¹,

Nag²

2013

J Bioequiv Availab

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Introduction: The choice of muscle relaxant for endotracheal intubation may be straightforward in selective cases, but in most patients, who are otherwise uncomplicated, poses a dilemma among anesthesiologists and intensivists. The authors examined the most commonly used muscle relaxants (Vecuronium, atracurium and rocuronium) in equipotent doses and compared the most vital parameters, i.e., rapidity of development of clinically acceptable intubating condition and quality of laryngoscopic view. Method: 150 adult patients of 18 to 50 y of age were recruited randomly into 3 equal groups having 50 patients (n=50) in each and equipotent dose of vecuronium, atracurium and rocuronium was administered. Endotracheal intubations were attempted every 30 seconds till excellent or good intubating conditions were achieved upto a maximum of 240 s. The available data were analyzed statistically. Results: The three study groups were comparable in terms of the demographic characteristics. The quality of intubating condition was rated significantly better with Rocuronium than with Vecuronium and Atracurium. Time required to achieve successful intubation was also significantly less with rocuronium than with Vecuronium (107.48 ± 1.98*6.583 s vs. 165.46 ± 1.98*6.790 s) and Atracurium (107.48 ± 1.98*6.583 s vs. 195.43 ± 1.98*6.583 s). Excellent laryngoscopic condition was found in more patients with rocuronium at 60 and 90 s and number of successful intubation was also higher. Conclusion: Therefore, the study confirms that rocuronium produces clinically acceptable intubating condition earlier than the other two drugs and the quality of intubating condition is better in terms of laryngoscopic view.

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Section: Group a (N=50)supporting

confidence: 85%

Quality of Laryngoscopic View and Rapidity of Development of Intubating Conditions after Atracurium, Vecuronium and Rocuronium: A Randomized Controlled Study

Mitra¹,

Nag²

2013

J Bioequiv Availab

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“…-38.7 vs -57.9 s, respectively). The difference in time onset of action between rocuronium 5 24 600 108 ± 24 24 80 204 ± 48 Magorian et al 6 10 600 89 ± 33 10 100 144 ± 39 10 900 75 ± 28 10 1200 55 ± 14 Alvarez-Gómez et al 8 20 600 135 ± 71 20 100 166 ± 46 McCoy et al 9 10 300 52 ± 11 10 40 136 ± 47 van den Broek et al 10 20 600 172 ± 71 20 100 192 ± 71 Audibert et al 11 10 600 300 ± 77 10 100 280 ± 74 Chetty et al 12 15 450 313 ± 74.3 8 75 331.9 ± 78.3 De Almeida et al 13 12 15 20 600 92 ± 46.9 20 100 112 ± 33.3 Lin et al 16 30 600 54.9 ± 10.9 30 100 102 ± 26.9 Posso et al 18 20 15 600 50 ± 3 1 5 100 154 ± 15 Kopman et al 21 10 350 246 ± 48 10 45 324 ± 51 Balcioglu et al 22 20 600 68 ± 9.8 20 100 105 ± 16.7 Ünlügenç et al 23 20 Data are the mean±SD. and vecuronium as measured by EMG was approximately 50% less than that determined by AMG or MMG.…”

Section: Resultsmentioning

confidence: 99%

“…1). 4–26 Two studies, each containing one effect size, did not report the mean and SD or SEM and were therefore excluded from the analysis. Thus, analysis in the present study was based on 21 studies containing 29 effect sizes (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Meta‐analysis of the Differences in the Time to Onset of Action Between Rocuronium and Vecuronium

Nava-Ocampo

Velázquez-Armenta

Moyao‐García

et al. 2006

Clin Exp Pharma Physio

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1. The aim of the present study was to conduct a meta-analysis of the magnitude of differences in the onset of action (T(max)) between rocuronium and vecuronium. 2. A search was made in PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register and Cochrane Database on Systematic Reviews. Studies comparing the T(max) at the adductor policies between rocuronium and vecuronium administered as an intravenous bolus were included in the study. Twenty-nine effect sizes obtained from 21 studies were included. 3. The result of the meta-analysis of differences was -57.9 s (95% confidence interval -71.4 to -44.3 s), favouring rocuronium over vecuronium. The smallest difference in T(max) between these neuromuscular-blocking agents was observed in children (-19.1 s). The difference in T(max) between rocuronium and vecuronium in female patients was -38.7 s. The difference in T(max) between rocuronium and vecuronium measured by electromyography was approximately 50% shorter than that determined by acceleromyography or mechanomyography. In a subanalysis between rocuronium 600 mg/kg versus vecuronium 100 mg/kg, the difference in T(max) between them was very similar to that obtained in the general meta-analysis. 4. According to subanalyses of patient age and sex, drug dose and neuromuscular monitoring systems, the T(max) of rocuronium was approximately 20-70 s faster than that of vecuronium.

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Sugammadex for the reversal of muscle relaxation in general anaesthesia: a systematic review and economic assessment

Chambers

Paulden²,

Paton³

et al. 2010

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of project...

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Rocuronium Bromide in Dental Day Case Anaesthesia—A Comparison with Atracurium and Vecuronium

Cited by 5 publications

References 13 publications

Quality of Laryngoscopic View and Rapidity of Development of Intubating Conditions after Atracurium, Vecuronium and Rocuronium: A Randomized Controlled Study

Quality of Laryngoscopic View and Rapidity of Development of Intubating Conditions after Atracurium, Vecuronium and Rocuronium: A Randomized Controlled Study

Meta‐analysis of the Differences in the Time to Onset of Action Between Rocuronium and Vecuronium

Sugammadex for the reversal of muscle relaxation in general anaesthesia: a systematic review and economic assessment

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