Rocuronium Use in Anaesthetics Protocol in Canine Patients with Orthopedic Disease

Abstract

In modern veterinary medicine, like in human medicine all major surgery procedures must be performed under balanced anaesthesia. This protocol contained substances that insure: neurovegetativ protection, analgesia, miorelaxation, hypnosis. Rocuronium represent a nondepolarizing agent, intermediate acting ( 60-120 seconds), with relative long effects ( 40-90 minutes), and with the posibility of effect reversal ( agents-Sugammadex). The aim of this study was monitorization of clinical, haematological and biochemical parameters perioperative in dogs scheduled for orthopedic procedures. This study was performed on ive canine patients (different breed, with age between 4 months to 11 years), scheduled for femoral had resection procedure. In this dogs balanced anaesthesia was performed: induction with propofol to effect, maintained with sevo lurane 2.5%; analgesic component: fentanyl 3μg/kg b.w.-bolus followed by CRI 5 μg/kg b.w./min, the neuromuscular blocking agent was represented by rocuronium 0.4 mg/kg b.w. Haematological analysis were performed with Abacus Junior Vet 3 diff analyzer, biochemical parameters with UV-VIS Screen Master Touch Hospitex Diagnostic spectrophotometer, and electrolytes with GEM Premier 2000 analyzer. The majority of biochemical and mineral parameters suffered only small changes, without statistical importance. After the surgery we determined only a slight reduction of erythrocyte number, haemoglobin and PCV, a mild increase of γ-globulin. Regarding the clinical parameters only internal temperatures was modi ied. We recommend the use of rocuronium in orthopedic procedures for the advantages offered in the surgical act (profound miorelaxation) without any major biochemical, haematological, electrolytes alteration.

Application of neuromuscular blockade using Rocuronium for performing different surgeries and its reversal by Neostigmine-Glycopyrrolate combination in dogs

“…All the values of ALT and AST at different time intervals were well within the normal physiological limits. A similar trend of decrease in ALT and AST postoperatively was also recorded by Popovici et al (2014) in their study on dogs undergoing orthopaedic surgery. Improved supply of blood to the liver as a result of administering propofol might have caused a fall in the ALT and AST in dogs (Khurana 2014).…”

“…Decrease in the values of TLC, Hb and PCV could be the result of pooling of blood cells in the circulatory system into the spleen or other reservoirs due to sympathetic activity (Wagner et al 1991). Popovici et al (2014) stated that the decrease in TLC might be due to the migration of white blood cells from circulation to the site of surgery.…”

“…Easy reduction of the fracture with minimal tissue trauma was possible and bone nibbling was not required for reduction of the fracture ends. Popovici et al (2014) in their study used rocuronium for orthopaedic surgeries in dogs and concluded that rocuronium provided very good muscle relaxation. In ovariohysterectomy surgeries, the appropriate level of abdominal muscle relaxation and overall easiness in surgical handling was observed which further helped in the easy exteriorization of the ovarian stump.…”

Quantitative evaluation of the biomechanical and viscoelastic properties of the dog patellar tendon in response to neuromuscular blockade at different stifle angles

“…The effects of different treatments (control and muscle relaxation) on PT tone depended on stifle angle position. In the normal position, PT tone was significantly higher in the control group (22.99 ± 0.99 Hz) than in the muscle relaxation group (18.81 ± 0.44 Hz) (F [ 1 , 24 ] = 372.825; P < 0.001), with a mean difference of 4.18 Hz (95% CI [3.73, 4.62]). In the extended position, PT tone was significantly higher in the control group (27.66 ± 0.55 Hz) than in the muscle relaxation group (24.67 ± 0.54 Hz) (F [ 1 , 24 ] = 2,361.062; P < 0.001), with a mean difference of 2.99 Hz; (95% CI [2.86, 3.11]).…”

“…In the extended position, PT tone was significantly higher in the control group (27.66 ± 0.55 Hz) than in the muscle relaxation group (24.67 ± 0.54 Hz) (F [ 1 , 24 ] = 2,361.062; P < 0.001), with a mean difference of 2.99 Hz; (95% CI [2.86, 3.11]). In the flexed position, PT tone was also significantly higher in the control group (31.61 ± 0.46 Hz) than in the muscle relaxation group (27.68 ± 0.53 Hz) (F [ 1 , 24 ] = 1,486.196; P < 0.001), with a mean difference of 3.93 Hz (95% CI [3.72, 4.14]).…”