Rodent-associated<i>Bartonella</i>Febrile Illness, Southwestern United States

Iralu, Jonathan; Bai, Ying; Crook, Larry; Tempest, Bruce; Simpson, Gary L.; McKenzie, Taylor; Koster, Frederick

doi:10.3201/eid1207.040397

Cited by 37 publications

(28 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The genus Bartonella is associated with aerobic, fastidious, gram-negative, slow-growing bacteria and consists of 20 species and three subspecies at the present time (19). These microorganisms infect the erythrocytes of their mammalian hosts, and some species cause a wide spectrum of illness, such as chronic bacteremia, fever, and endocarditis.…”

mentioning

confidence: 99%

Prevalence and Genetic Diversity of Bartonella Species Isolated from Wild Rodents in Japan

Inoue

Maruyama

Kabeya

et al. 2008

Appl Environ Microbiol

View full text Add to dashboard Cite

Here, we describe for the first time the prevalence and genetic properties of Bartonella organisms in wild rodents in Japan. We captured 685 wild rodents throughout Japan (in 12 prefectures) and successfully isolated Bartonella organisms from 176 of the 685 rodents (isolation rate, 25.7%). Those Bartonella isolates were all obtained from the rodents captured in suburban areas (rate, 51.8%), but no organism was isolated from the animals captured in city areas. Sequence analysis of rpoB and gltA revealed that the Bartonella isolates obtained were classified into eight genetic groups, comprising isolates closely related to B. grahamii (A-I group), B. tribocorum and B. elizabethae (B-J group), B. tribocorum and B. rattimassiliensis (C-K group), B. rattimassiliensis (D-L group), B. phoceensis (F-N group), B. taylorii (G-O group), and probably two additional novel Bartonella species groups (E-M and H-P). B. grahamii, which is one of the potential causative agents of human neuroretinitis, was found to be predominant in Japanese rodents. In terms of the relationships between these Bartonella genetic groups and their rodent species, (i) the A-I, E-M, and H-P groups appear to be associated with Apodemus speciosus and Apodemus argenteus; (ii) the C-K, D-L, and F-N groups are likely implicated in Rattus rattus; (iii) the B-J group seems to be involved in Apodemus mice and R. rattus; and (iv) the G-O group is probably associated with A. speciosus and Clethrionomys voles. Furthermore, dual infections with two different genetic groups of bartonellae were found in A. speciosus and R. rattus. These findings suggest that the rodent in Japan might serve as a reservoir of zoonotic Bartonella infection.

show abstract

mentioning

confidence: 99%

Prevalence and Genetic Diversity of Bartonella Species Isolated from Wild Rodents in Japan

Inoue

Maruyama

Kabeya

et al. 2008

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…positivity in mice and the role of ticks in the transmission of these agents (21). Iralu et al (2006) reported rodent-originated Bartonella infection in 9 of 76 patients (12%) with fever of unknown origin, diagnosed serologically with seroconversion and antibody presence in high titers (16). According to the present data, Bartonella infections should be among the differential diagnosis of cases with fever of unknown origin, which may be due to tick bites, and further studies should be performed accordingly.…”

Section: Resultsmentioning

confidence: 99%

Detection of Bartonella spp. in field mice (Microtus socialis) by culture and PCR

ÇELEBİ¹

2013

Ankara Üniversitesi Veteriner Fakültesi Dergisi

View full text Add to dashboard Cite

Summary:The species within the genus Bartonella are intracellular bacteria causing long-lasting bacteremia in humans and animals. Eleven Bartonella species isolated from animals have zoonotic characteristics. The four of zoonotic Bartonella species have been reported in rodents. In this study, Bartonella spp. in 42 field mice, (Microtus socialis), captured from one spot in Central Anatolia Region were investigated by culture and molecular methods. The positivity of Bartonella was 16.6% (7/42) by culture, and 57.1% (24/42) by PCR (Polymerase Chain Reaction) from liver tissues of field mice. The citrate synthesis gene regions (gltA) of the isolated seven strains were identified by DNA sequencing analysis. It was determined that five isolates were Bartonella taylorii, and two isolates were Bartonella grahamii which are zoonotic. This study is the first report for the presence of Bartonella spp. in rodents in Turkey.Key words: Bartonella, Microtus socialis, PCR. Tarla farelerinde (Microtus socialis) Bartonella Spp. varlığının kültür ve PCR yöntemleriyle belirlenmesiÖzet: Bartonella genusundaki türler insanlarda ve hayvanlarda uzun süreli bakteriyemiye neden olan hücre içi bakterilerdir.Hayvanlardan izole edilen onbir Bartonella türü zoonoz karakterdedir. Zoonoz Bartonella türlerinden dördü rodentlerde bildirilmiştir. Bu çalışmada Orta Anadolu Bölgesinde bir odaktan yakalanan 42 Microtus socialis türü tarla faresinde kültür ve moleküler yöntemlerle Bartonella spp. araştırıldı. Tarla farelerinde, karaciğer dokusundan kültür ile % 16.6 (7/42), PCR (Polimeraz Zincir Reaksiyonu) ile % 57,1 (24/42) Bartonella pozitifliği tespit edildi. Kültürde izole edilen yedi izolatın, sitrat sentez gen bölgesi (gltA) DNA dizi analizi ile tür tanımlamaları yapıldı. İzolatlardan beşi Bartonella taylorii, ikisi zoonotik bir tür olan Bartonella grahamii olarak belirlendi. Bu çalışma ile ülkemizde rodentlerde ilk defa Bartonella türlerinin varlığı bildirilmektedir.

show abstract

“…positivity in mice and the role of ticks as a transmitting agent (24). Iralu et al reported rodentborne Bartonella infection in 9 (12%) of 76 patients with fever of unknown origin, diagnosed serologically with seroconversion and high antibody titers (15). According to the available data in Turkey related to tick-borne infections with fever of unknown reason encourages us to study further.…”

Section: Discussionmentioning

confidence: 99%

Bartonella species in wild small mammals in Western Black Sea Region of Turkey

KARAGÖZ¹

2015

Ankara Üniversitesi Veteriner Fakültesi Dergisi

View full text Add to dashboard Cite

show abstract

Rodent-associatedBartonellaFebrile Illness, Southwestern United States

Abstract: Patients showed seroconversion to rodent-associated Bartonella antigens, but not to Bartonella pathogenic for humans.

Cited by 37 publications

References 30 publications

Prevalence and Genetic Diversity of Bartonella Species Isolated from Wild Rodents in Japan

Prevalence and Genetic Diversity of Bartonella Species Isolated from Wild Rodents in Japan

Detection of Bartonella spp. in field mice (Microtus socialis) by culture and PCR

Bartonella species in wild small mammals in Western Black Sea Region of Turkey

Contact Info

Product

Resources

About