RodentSQL: A Software Suite for Colony Management of Animal Protocols

Pawar, Shrikant; Batra, Harshul

doi:10.4155/fsoa-2018-0054

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…2 In addition, the regulation in place requires thorough tracking of individual animals, data capture and scientific data management. Recently, diverse freely available non-commercial programs and commercially distributed management systems were developed 3,4 to allow accurate data integration and management in accord with specific requirements of the institution. Most of these systems are designed to increase workflow efficiency, data security and animal welfare, 5 but do not allow efficient sharing of information to promote a reduction in animal numbers.…”

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confidence: 99%

3R Blackboard: A platform for animal and organ sharing

et al. 2022

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Since the embedding of the principles of the 3Rs (Replacement, Reduction and Refinement) in national and international regulations on the use of animals, scientists have been challenged to find ways to reduce the number of animals in their research. Here, we present a digital platform, called ‘3R Backboard’, linked to a laboratory animal management system, which facilitates sharing of surplus biological materials from animals (e.g. tissues, organs and cells) to other research teams. Based on information provided, such as genotype, age and sex, other animal workers were able to indicate their interest in collecting specific tissues and to communicate with the person providing the animals. A short pilot study of this approach conducted in a limited academic environment presented strong evidence of its effectiveness and resulted in a notable reduction of the number of mice used. In addition, the use of 3R Blackboard led to resource saving, knowledge exchange and even establishment of new collaboration.

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confidence: 99%

3R Blackboard: A platform for animal and organ sharing

et al. 2022

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TopoDB: a novel multifunctional management system for laboratory animal colonies

et al. 2020

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Animal models are widely employed in basic research to test mechanistic hypotheses in a complex biological environment as well as to evaluate the therapeutic potential of candidate compounds in preclinical settings. Rodents, and in particular mice, represent the most common in vivo models for their small size, short lifespan and possibility to manipulate their genome. Over time, a typical laboratory will develop a substantial number of inbred strains and transgenic mouse lines, requiring a substantial effort, in both logistic and economic terms, to maintain an animal colony for research purposes and to safeguard the integrity of results. To meet this need, here we present TopoDB, a robust and extensible web-based platform for the rational management of laboratory animals. TopoDB allows an easy tracking of individual animals within the colony and breeding protocols as well as the convenient storage of both genetic and phenotypic data generated in the different experiments. Altogether, these features facilitate and enhance the design of in vivo research, thus reducing the number of necessary animals and the housing costs. In summary, TopoDB represents a novel valuable tool in modern biomedical research. Database URL : https://github.com/UCSF-MS-DCC/TopoDB

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MyVivarium: A cloud-based lab animal colony management application with near-realtime ambient sensing

Vidva,

Raza,

Prabhakaran

et al. 2024

Preprint

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Research-animal colony management is a critical determinant of scientific productivity in labs conducting preclinical research. However, labs generally usead hocpaper-based or spreadsheet-based methods to manage animal colonies. Current software-based solutions are limited based on cost, ease of implementation and deployment, and lack of remote access. In addition, most current solutions lack integration of realtime monitoring of ambient variables that affect colony wellbeing and breeding efficiency. Keeping these functionalities in mind, we builtMyVivarium– a cloud-based animal colony database management web application that can be easily deployed and sustained for a cost comparable to starting and maintaining a lab website. For mouse colony management, MyVivarium allows for the tracking of individual mice or litters within holding-cage and breeding-cage records by multiple users at designated levels of access. Physical identities of cages are mapped onto the database using printable cage-card templates with cage-specific QR codes, enabling quick record updating using mobile devices. Tasks can be easily assigned with reminders for experiments or cage maintenance. Finally, MyVivarium integrates near-realtime internet-of-things (IoT)-based ambient sensing using low-cost open-source hardware to track humidity, temperature, vivarium-worker activity, and room illuminance. Taken together, MyVivarium is a novel open-source cloud-based application template that can serve as a low-cost, simple, and efficient solution for digital management of research animal colonies.

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RodentSQL: A Software Suite for Colony Management of Animal Protocols

Cited by 3 publications

References 6 publications

3R Blackboard: A platform for animal and organ sharing

3R Blackboard: A platform for animal and organ sharing

TopoDB: a novel multifunctional management system for laboratory animal colonies

MyVivarium: A cloud-based lab animal colony management application with near-realtime ambient sensing

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