Rodlet cells, fish immune cells and a sentinel of parasitic harm in teleost organs

Dezfuli, Bahram Sayyaf; Pironi, Flavio; Maynard, Barbara; Simoni, Edi; Bosi, G.

doi:10.1016/j.fsi.2021.09.045

Cited by 18 publications

(28 citation statements)

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“…Extensive literature exists on histopathology caused by helminth parasitism of fish intestine and a recent review of Sayyaf Dezfuli et al . (2021 a , 2023 b ) provides update on this issue. With regards to cestode fish parasites, there have been numerous light investigations on histopathology of order Caryophyllidea (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The intestine is a particularly competitive ecological environment; infection of the alimentary canal by helminths has detrimental effects on digestive function; intestinal inhabitants have found ways to utilize the host to achieve a competitive advantage in this nutrient-rich environment (Loke and Harris, 2023). Attachment organ of endoparasitic worms often induces intense inflammation (Karanis and Taraschewski, 1993; Williams et al ., 2011; Sayyaf Dezfuli et al ., 2021 a , 2022). Inflammation is the host response to invasion by foreign organisms as well as to physical injury and serves to protect the host by evoking specific chemical and morphological alterations to the injured tissues (Johansson and Hansson, 2014; Birchenough et al ., 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Enteric helminth infections commonly incite inflammation of the digestive tract and in several records it was documented that the occurrence of a parasite within a host can induce the formation and/or recruitment of various inflammatory cells, at the site of infection (Molnár et al ., 2003; Sayyaf Dezfuli et al ., 2021 a ; Scholz et al ., 2021). Some of most common cell types associated with enteric parasite infections in fish are mast cells also known as eosinophilic granular cells (MCs) (Reite and Evensen, 2006; Sayyaf Dezfuli et al ., 2021 a ), rodlet cells (RCs) (Sayyaf Dezfuli et al ., 2022, 2023 a , 2023 b ), neutrophils (Dezfuli et al ., 2011) and mucous cells (Bosi et al ., 2017, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Infection of endemic chub Squalius tenellus with the intestinal tapeworm Caryophyllaeus brachycollis (Cestoda): histopathology and ultrastructural surveys

Sayyaf Dezfuli,

Franchella,

Bernacchia

et al. 2023

Parasitology

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The endemic chub Squalius tenellus (Heckel, 1843) was introduced more than 100 years ago to Lake Blidinje (Bosnia-Herzegovina). Only 1 species of enteric helminth was found in a sample of 35 chubs, the tapeworm Caryophyllaeus brachycollis (Janiszewska, 1953). The paper includes histopathological investigation with identification of innate immune cells involved in host reaction and molecular data allowed correct designation of the cestode species. Of 35 specimens of chub examined, 21 (60%) harboured individuals of C. brachycollis and a total of 1619 tapeworms were counted, the intensity of infection ranged from 1 to 390 worms per fish (46.2 ± 15.3, mean ± s.e.). Histopathological and ultrastructural investigations showed strict contact between the worm's body and the epithelia and increase in the number of mucous cells, rodlet cells among the epithelial cells. Within the tunica propria-submucosa, beneath the site of scolex attachment, numerous neutrophils and mast cells were noticed. This is the first study of the occurrence of C. brachycollis in chub from Lake Blidinje and on the response of the innate immune cells of S. tenellus to this tapeworm. Interestingly, in 3 very heavily infected chubs, perforation of the intestinal wall was documented; this is uncommon among cestodes which use fish as a definitive host.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Infection of endemic chub Squalius tenellus with the intestinal tapeworm Caryophyllaeus brachycollis (Cestoda): histopathology and ultrastructural surveys

Sayyaf Dezfuli,

Franchella,

Bernacchia

et al. 2023

Parasitology

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“…Intestinal parasites often induce changes in the morphology of the host tissue that might affect organ physiology (Fairweather, 1997). Inflammation due to fish enteric helminths is well documented (Dezfuli et al ., 2000, 2011 a , 2011 b ; Taraschewski, 2000; Sayyaf Dezfuli et al ., 2021 a , 2022) and consists of a complex series of homoeostatic mechanisms involving circulatory, immune, nervous and endocrine systems (Serna-Ducque and Esteban, 2020; Sayyaf Dezfuli et al ., 2021 a ). In at least some host–parasite systems, changes in host physiology are caused by parasite action on the fish neuroendocrine system (NES) (Øverli et al ., 2001; Herbison, 2017; Helland-Riise et al ., 2020).…”

Section: Introductionmentioning

confidence: 99%

Parasites and the neuroendocrine control of fish intestinal function: an ancient struggle between pathogens and host

et al. 2022

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Most individual fish in wild and farmed populations can be infected with parasites. Fish intestines can harbour protozoans, myxozoans and helminths, which include several species of digeneans, cestodes, nematodes and acanthocephalans. Enteric parasites often induce inflammation of the intestine; the pathogen provokes changes in the host physiology, which will be genetically selected for if they benefit the parasite. The host response to intestinal parasites involves neural, endocrine and immune systems and interaction among these systems is coordinated by hormones, chemokines, cytokines and neurotransmitters including peptides. Intestinal fish parasites have effects on the components of the enteric nervous and endocrine systems; mechanical/chemical changes impair the activity of these systems, including gut motility and digestion. Investigations on the role of the neuroendocrine system in response to fish intestinal parasites are very few. This paper provides immunohistochemical and ultrastructural data on effects of parasites on the enteric nervous system and the enteric endocrine system in several fish–parasite systems. Emphasis is on the occurrence of 21 molecules including cholecystokinin-8, neuropeptide Y, enkephalins, galanin, vasoactive intestinal peptide and serotonin in infected tissues.

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“…Butyrate increased eosinophil and rodlet cell area even after 1 week of feeding, while reduced the presence of mucus cells overtime (Figure 7), features associated with (chemically-induced) intestinal inflammation in zebrafish . Rodlet cells were first reported to act against fish parasites and later studies disclosed their granulocyte nature and include them as part of the innate fish immune system, increasing in number when exogeneous stressors were present (Iger and Abraham, 1997;Manera and Dezfuli, 2004;Reite and Evensen, 2006;Dezfuli et al, 2022).…”

Section: A B Discussionmentioning

confidence: 99%

What is up with that gut? : Using zebrafish to model host-microbe-feed interactions

Nadal

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Chapter 1 General introductionChapter 2 Exposure to antibiotics affects saponin immersion-induced immune stimulation and shift in microbial composition in zebrafish larvae Chapter 3 Environmental microbes determine macrophage response towards saponin-induced inflammation in zebrafish larvae Chapter 4 Zebrafish display cxcl8a-dependent selective thermal preference during inflammation Chapter 5 Feed, microbiota, and gut immunity: using the zebrafish model to understand fish health Chapter 6 Intestinal microbiota and immune modulation in zebrafish by fucoidan from Okinawa Mozuku (Cladosiphon okamuranus) Chapter 7 Omics and imaging combinatorial approach reveals butyrate-induced inflammatory effects in the zebrafish gut Chapter 8 General discussion Summary About the author List of publications Training and Supervision Plan (TSP) Acknowledgments Gut-associated terminologyApical: side of the cell membrane that faces the lumen.Basal: side of the cell membrane that faces the underlying connective tissue.Commensal bacteria: Naturally-occurring non-harmful bacteria for the host.Enterocyte: columnar absorptive cell of the gut epithelium.Epithelium: protective cell layer that marks the border between the outside (lumen) and the inside (tissue) of the gut.Lumen: cavity or channel that makes up the inside of the bowel.Microvilli: microscopic cellular membrane protrusions that increase the surface area to maximize nutrient absorption.Mucosal fold (villi): surface-enlarging finger-like projection that extends into the lumen of the gut. Tight junction: protein complexes (containing claudins, desmosomes, occludins and cadherins) that seal the space between the enterocytes in the gut epithelia.

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Rodlet cells, fish immune cells and a sentinel of parasitic harm in teleost organs

Cited by 18 publications

References 110 publications

Infection of endemic chub Squalius tenellus with the intestinal tapeworm Caryophyllaeus brachycollis (Cestoda): histopathology and ultrastructural surveys

Infection of endemic chub Squalius tenellus with the intestinal tapeworm Caryophyllaeus brachycollis (Cestoda): histopathology and ultrastructural surveys

Parasites and the neuroendocrine control of fish intestinal function: an ancient struggle between pathogens and host

What is up with that gut? : Using zebrafish to model host-microbe-feed interactions

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