Rol del Consumo de Alcohol y Antioxidantes sobre la Metilación Global del ADN y Cáncer

Sandoval, Cristian; Vásquez, Bélgica; Souza-Mello, Vanessa; Mandarim-de-Lacerda, Carlos Alberto; Sol, Mariano del

doi:10.4067/s0717-95022018000100367

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…A positive relationship between ADH activity and leukocyte ascorbic acid concentration has been discovered in people with liver disease [69]. Furthermore, the acetaldehyde produced has been associated with ethanolinduced hepatotoxicity [70,71], and when paired with hepatic CYP2E1 activation, these factors enhance oxidative stress in hepatocytes [12,33,72,73]. On the other hand, vitamin C has been demonstrated to protect against the detrimental effects of acetaldehyde in animal experiments [74].…”

Section: Vitamin Cmentioning

confidence: 99%

“…Vitamin E deficiency, according to earlier research, makes the liver more sensitive to alcohol [97]. In this sense, vitamin E has been demonstrated to have hepatoprotective characteristics in rat models, including membrane stability, reduced nuclear factor-kappa B activation, decreased TNF-α generation, and suppressed hepatic stellate cell activation [12,33,73,95].…”

Section: Vitamin Ementioning

confidence: 99%

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Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review

Sandoval¹,

Farías²,

Zamorano³

et al. 2022

Which Factors Contribute to Innovative Performance? A Case Study Applied to the Food and Beverage Industry

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Several studies have shown that blood vitamin levels are low in alcoholic patients. In effect, alcohol use abuse is considered a chronic disease that promotes the pathogenesis of many fatal diseases, such as cancer and liver cirrhosis. The alcohol effects in the liver can be prevented by antioxidant mechanisms, which induces enzymatic as well as other nonenzymatic pathways. The effectiveness of several antioxidants has been evaluated. However, these studies have been accompanied by uncertainty as mixed results were reported. Thus, the aim of the present review article was to examine the current knowledge on vitamin deficiency and its role in chronic liver disease. Our review found that deficiencies in nutritional vitamins could develop rapidly during chronic liver disease due to diminished hepatic storage and that inadequate vitamins intake and alcohol consumption may interact to deplete vitamin levels. Numerous studies have described that vitamin supplementation could reduce www.videleaf.com hepatotoxicity. However, further studies with reference to the changes in vitamin status and the nutritional management of chronic liver disease are in demand.

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Section: Vitamin Cmentioning

confidence: 99%

Section: Vitamin Ementioning

confidence: 99%

Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review

Sandoval¹,

Farías²,

Zamorano³

et al. 2022

Which Factors Contribute to Innovative Performance? A Case Study Applied to the Food and Beverage Industry

View full text Add to dashboard Cite

show abstract

“…Pancreatic acinar cells use both oxidative and nonoxidative pathways to metabolize alcohol [16][17][18]. In fact, previous studies have demonstrated that alcohol probably alters the class II alcohol dehydrogenase (ADH2) [19] and ADH3 isoforms [19,20] to inhibit acinar ethanol oxidation.…”

Section: Introductionmentioning

confidence: 99%

β-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview

Sandoval,

Vera,

Birditt

et al. 2024

IJMS

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Alcohol is believed to harm acinar cells, pancreatic ductal epithelium, and pancreatic stellate cells. After giving ethanol and/or β-carotene to C57BL/6 mice, our goal was to evaluate their biochemistry, histology, and morpho-quantitative features. There were six groups of C57BL/6 mice: 1. Group C (control), 2. Group LA (low-dose alcohol), 3. Group MA (moderate-dose alcohol), 4. Group B (β-carotene), 5. Group LA + B (low-dose alcohol combined with β-carotene), and 6. Group MA + B (moderate-dose alcohol combined with β-carotene). After the animals were euthanized on day 28, each specimen’s pancreatic tissue was taken. Lipase, uric acid, and amylase were assessed using biochemical assessment. Furthermore, the examination of the pancreatic structure was conducted using Ammann’s fibrosis scoring system. Finally, the morpho-quantitative characteristics of the pancreatic islets and acinar cells were determined. In the serum of the MA + B group, there were higher amounts of total amylase (825.953 ± 193.412 U/L) and lower amounts of lipase (47.139 ± 6.099 U/L) (p < 0.05). Furthermore, Ammann’s fibrosis punctuation in the pancreas revealed significant variations between the groups (p < 0.001). Finally, the stereological analysis of pancreatic islets showed that the groups were different (p < 0.001). These findings suggest that antioxidant treatments might help decrease the negative effects of ethanol exposure in animal models.

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Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review

et al. 2022

View full text Add to dashboard Cite

Several studies have shown that blood vitamin levels are low in alcoholic patients. In effect, alcohol use abuse is considered a chronic disease that promotes the pathogenesis of many fatal diseases, such as cancer and liver cirrhosis. The alcohol effects in the liver can be prevented by antioxidant mechanisms, which induces enzymatic as well as other nonenzymatic pathways. The effectiveness of several antioxidants has been evaluated. However, these studies have been accompanied by uncertainty as mixed results were reported. Thus, the aim of the present review article was to examine the current knowledge on vitamin deficiency and its role in chronic liver disease. Our review found that deficiencies in nutritional vitamins could develop rapidly during chronic liver disease due to diminished hepatic storage and that inadequate vitamins intake and alcohol consumption may interact to deplete vitamin levels. Numerous studies have described that vitamin supplementation could reduce hepatotoxicity. However, further studies with reference to the changes in vitamin status and the nutritional management of chronic liver disease are in demand.

show abstract

Rol del Consumo de Alcohol y Antioxidantes sobre la Metilación Global del ADN y Cáncer

Cited by 5 publications

References 40 publications

Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review

Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review

β-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview

Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review

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