Role and Results of Segmental Allografts for Acetabular Segmental Bone Deficiency

Garbuz, Donald S.; Penner, Murray

doi:10.1016/s0030-5898(05)70325-4

Cited by 12 publications

(2 citation statements)

References 45 publications

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“…Depending on the location and size of the defect, structured or morcellised allografts are used (13, 14). Structured allografts provide more stability and support for the implant (3, 15), whereas morcellised bone grafts enable rapid osteointegration and remodelling (8, 16–17–18).…”

Section: Introductionmentioning

confidence: 99%

Major Acetabular Defects Treated with the Burch-Schneider Antiprotrusion Cage and Impaction Bone Allograft in a Large Series: A 5- to 7- Year Follow-up Study

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Major Acetabular Defects Treated with the Burch-Schneider Antiprotrusion Cage and Impaction Bone Allograft in a Large Series: A 5- to 7- Year Follow-up Study

et al. 2016

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“…Both experimental and clinical studies have demonstrated that live autologous grafts are superior to processed or devitalized allografts when analyzing bone incorporation, repair, and remodeling [1, 2]. However, due to the limited availability of autologous bone grafts, and problems with chronic pain at the donor site [3, 4], processed allografts remain an attractive substitute for bone grafting.…”

Section: Introductionmentioning

confidence: 99%

The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice

et al. 2014

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Structural bone allografts are widely used in the clinic to treat critical sized bone defects, despite lacking the osteoinductive characteristics of live autografts. To address this, we generated revitalized structural allografts wrapped with mesenchymal stem/progenitor cell (MSC) sheets, which were produced by expanding primary syngenic bone marrow derived cells on temperature-responsive plates, as a tissue engineered periosteum. In vitro assays demonstrated maintenance of the MSC phenotype in the sheets, suggesting that short-term culturing of MSC sheets is not detrimental. To test their efficacy in vivo, allografts wrapped with MSC sheets were transplanted into 4-mm murine femoral defects and compared to allografts with direct seeding of MSCs and allografts without cells. Evaluations consisted of x-ray plain radiography, 3D microCT, histology, and biomechanical testing at 4- and 6-weeks post-surgery. Our findings demonstrate that MSC sheets induce prolonged cartilage formation at the graft-host junction and enhanced bone callus formation, as well as graft-host osteointegration. Moreover, a large periosteal callus was observed spanning the allografts with MSC sheets, which partially mimics live autograft healing. Finally, biomechanical testing showed a significant increase in the structural and functional properties of MSC sheet grafted femurs. Taken together, MSC sheets exhibit enhanced osteogenicity during critical sized bone defect repair, demonstrating the feasibility of this tissue engineering solution for massive allograft healing.

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Aseptic Loosening of Total Hip Replacements - Acetabulum

Gollwitzer

Eisenhart-Rothe

Gradinger

2014

European Surgical Orthopaedics and Traumatology

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Role and Results of Segmental Allografts for Acetabular Segmental Bone Deficiency

Cited by 12 publications

References 45 publications

Major Acetabular Defects Treated with the Burch-Schneider Antiprotrusion Cage and Impaction Bone Allograft in a Large Series: A 5- to 7- Year Follow-up Study

Major Acetabular Defects Treated with the Burch-Schneider Antiprotrusion Cage and Impaction Bone Allograft in a Large Series: A 5- to 7- Year Follow-up Study

The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice

Aseptic Loosening of Total Hip Replacements - Acetabulum

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