Role of adult bone marrow stem cells in the repair of ischemic myocardium: Current state of the art

Charwat, Silvia; Gyöngyösi, Mariann; Lang, Irene M.; Graf, Senta; Beran, Gilbert; Hemetsberger, Rayyan; Nyolczas, Noémi; Sochor, Heinz; Glogar, Dietmar

doi:10.1016/j.exphem.2008.01.005

Cited by 61 publications

(46 citation statements)

References 86 publications

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“…No cellbased therapeutics are currently on the market for treating stroke, which had an estimated cost of over $68.9 billion dollars to patients in both direct and indirect costs in the United States alone in 2009 (LloydJones et al 2009). Pre-clinical animal studies point to benefit derived from transplanted stem cells following ischemic injury in the CNS (Chen et al 2001c;Chen et al 2003b;Li and Chopp 2009;Ohtaki et al 2008;Shyu et al 2006;Yasuhara et al 2008;Yasuhara et al 2006b;Zhao et al 2002), in the heart (reviewed in (Charwat et al 2008;Ting et al 2008)), the peripheral vasculature (Aranguren et al 2008) and other inflammatory injury models (Aggarwal and Pittenger 2005;Kovacsovics-Bankowski et al 2008;Kovacsovics-Bankowski et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke

Mays¹,

Borlongan²,

Yasuhara³

et al. 2010

J Exp Stroke Transl Med

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Section: Introductionmentioning

confidence: 99%

Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke

Mays¹,

Borlongan²,

Yasuhara³

et al. 2010

J Exp Stroke Transl Med

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“…The effect of irradiation separates from marrow engraftment cannot be ruled out in these studies, but appears unlikely. Similarly, work by Zhao et al [20], as well as studies of the effects of marrow cells infusions on ischemic myocardium in both animals and patients, has also shown functional effects which did not seem to be explained by marrow cells converting to differentiated organ-specifi c cells [23,[28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Marrow Cell Infusion Attenuates Vascular Remodeling in a Murine Model of Monocrotaline-Induced Pulmonary Hypertension

Aliotta

Keaney

Warburton

et al. 2009

Stem Cells and Development

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There have been reports of marrow cells converting into pulmonary epithelial cells after marrow transplantation in irradiated mice. We evaluated the impact of whole bone marrow (WBM) infusion in mice, with or without total body irradiation (TBI), treated with saline or monocrotaline (MCT), which induces pulmonary hypertension (PH). C57BL/6 mice were injected with MCT or saline weekly for 4 weeks. Cohorts were then infused with saline vehicle (vehicle) or WBM from C57BL/-Tg(UBC-GFP)30Scha/J mice, with or without previous TBI (WBM or WBM/ TBI). Four weeks later, right ventricular peak pressures (RVPP), right ventricular free wall-to-body weight ratios (RV/BW), and pulmonary vessel wall thickness-to-blood vessel diameter ratios (PVWT/D) were determined. WBM infusion and WBM following TBI induced increases in RVPP and RV/BW in saline-treated mice, while only TBI-exposed mice showed additional increases in PVWT/D. MCT increased RVPP, RV/BW, and PVWT/D in mice given vehicle or WBM alone, but not in mice given WBM/TBI. RVPP and RV/BW were not signifi cantly lower in MCT mice given WBM/TBI than in MCT mice treated with vehicle, but MCT-treated mice given WBM or TBI/ WBM had signifi cantly lower PVWT/D compared to MCT-treated mice given saline vehicle. No donor WBMderived pulmonary vascular cells were detected, suggesting that the observed effects of WBM infusion may be due to paracrine effects separate from cell conversions. The observation of PH after marrow infusion suggests an additional mechanism for lung toxicity seen in marrow transplantation. In conclusion, WBM alone appears to increase RVPP and RV/BW in normal mice but the combination of WBM and TBI attenuates MCT-induced PH.

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“…Adult BM is a rich source of HSCs and hematopoietic progenitor cells (HPCs) (35,36,38). These undifferentiated cells are able to differentiate into various cell types including myeloid and endothelial cells.…”

Section: Adult Bm-derived Progenitors Differentiate Into Endothelial mentioning

confidence: 99%

“…Other, less common diseases of the retina such as macular telangiectasia (MacTel) and retinal angiomatous proliferation (RAP) involve focal vascular abnormalities that may also be associated with neuronal (e.g., cone photoreceptor) loss. "Crosstalk" between local vascular networks and the tissues they supply may help maintain physiological homeostasis and function in a variety of tissues including the retina (35)(36)(37). In fact, endothelial cells are known to provide trophic substances that greatly stimulate self renewal and directed differentiation of neural stem cells in the central nervous system (38) as well as hepatocytes during liver regeneration in response to injury (39).…”

Section: Stem Cells and Therapy Of Retinal Vascular Diseasesmentioning

confidence: 99%

Stemming vision loss with stem cells

Marchetti¹,

Krohne²,

Friedlander³

et al. 2010

J. Clin. Invest.

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Dramatic advances in the field of stem cell research have raised the possibility of using these cells to treat a variety of diseases. The eye is an excellent target organ for such cell-based therapeutics due to its ready accessibility, the prevalence of vasculo-and neurodegenerative diseases affecting vision, and the availability of animal models to demonstrate proof of concept. In fact, stem cell therapies have already been applied to the treatment of disease affecting the ocular surface, leading to preservation of vision. Diseases in the back of the eye, such as macular degeneration, diabetic retinopathy, and inherited retinal degenerations, present greater challenges, but rapidly emerging stem cell technologies hold the promise of autologous grafts to stabilize vision loss through cellular replacement or paracrine rescue effects.

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Role of adult bone marrow stem cells in the repair of ischemic myocardium: Current state of the art

Cited by 61 publications

References 86 publications

Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke

Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke

Marrow Cell Infusion Attenuates Vascular Remodeling in a Murine Model of Monocrotaline-Induced Pulmonary Hypertension

Stemming vision loss with stem cells

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