Role of age and comorbidities in mortality of patients with infective endocarditis

Abstract

When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged < 65 years(p < 0.001) for both in-hospital and 1-year mortality. Conclusion: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the < 65-year group.

Differences in mortality in patients undergoing surgery for infective endocarditis according to age and valvular surgery

“…In patients ≥80 years the in-hospital mortality was 34.7% and age ≥ 80 years were associated with an increased mortality. From our data, an in-hospital mortality of 20.3% was identified among patients ≥75 years [ 34 ]. A single-center study from Australia, investigated 465 patients undergoing cardiac surgery for IE and found, among other factors, that increasing age, active bacterial endocarditis, and a high European System for Cardiac Operative Risk Evaluation score were associated with an increased risk of in-hospital mortality [ 35 ].…”

Potential Fossilized Sulfide-Oxidizing Bacteria in the Upper Miocene Sulfur-Bearing Limestones From the Lorca Basin (SE Spain): Paleoenvironmental Implications

“…This trend toward more restricted conditions culminated with deposition of two evaporitic units consisting of gypsum (Main Gypsum Unit; Rouchy et al, 1998) and halite (García-Veigas, 1993; Ayora et al, 1994; García-Veigas et al, 1994). These evaporitic units document the total isolation of the basin and the subsequent establishment of continental conditions (Montenat et al, 1990; Ortí et al, 1993; Rouchy et al, 1998; Krijgsman et al, 2000; Playà et al, 2000). The age of the Tripoli Fm.…”

Multimodality imaging in the diagnosis and management of prosthetic valve endocarditis: A contemporary narrative review

“…There is conflicting data regarding the age group most susceptible to develop PVE. In the Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES) Database registry, which included 3120 patients with IE, patients 65-79 years old (elderly) had a significantly higher incidence of PVE compared with those < 65 years (young) and ≥ 80 years old (octogenarian) (37.3% vs 24.4% and 26.3%, respectively, P < 0.001)[ 28 ]. This observation was also demonstrated by López et al [ 29 ], studying a cohort of 600 Left-sided IE patients 40% of whom had PVE, showing a similar age distribution[ 29 ].…”

“…In patients with PVE, there is male predominance with 3:1 ratio across various studies[ 14 , 28 - 30 ]. This ratio changes towards 1:1 in the octogenarian group[ 28 - 30 ].…”

“…In patients with PVE, there is male predominance with 3:1 ratio across various studies[ 14 , 28 - 30 ]. This ratio changes towards 1:1 in the octogenarian group[ 28 - 30 ]. Interestingly, in an observational study of 621 patients with left-sided IE, mitral mechanical valve PVE was more common in women than in men[ 31 ].…”