Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Dewailly, Didier; Barbotin, Anne‐Laure; Agathe, Dumont; Catteau-Jonard, Sophie; Robin, Geoffroy

doi:10.3389/fendo.2020.00641

Cited by 63 publications

(58 citation statements)

References 72 publications

(120 reference statements)

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“…There was an inverse relationship between serum FSH and AMH levels in PCOS patients, which has been reported in previous studies (11,33,34) and remains unexplained to date (35,36). Our opinion is consistent with a previous study (36) in which it is not believed that the negative impact of FSH on the production of AMH was responsible for the phenomenon. In contrast, there is evidence showing the positive impact of FSH on the production of AMH in the case of congenital gonadotrophic insufficiency (37).…”

Section: Discussionsupporting

confidence: 92%

“…Decreased AMH production by the follicle unit instead of hemodilution may contribute to reduced AMH with increasing BMI (31). There was an inverse relationship between serum FSH and AMH levels in PCOS patients, which has been reported in previous studies (11,33,34) and remains unexplained to date (35,36). Our opinion is consistent with a previous study (36) in which it is not believed that the negative impact of FSH on the production of AMH was responsible for the phenomenon.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, ovarian hyperstimulation and the associated high estrogen-induced endometrial receptivity damage no longer affects the FET cycle outcome. Although there are data showing that high AMH concentration may cause disturbed folliculogenesis in PCOS ( 33 , 36 , 54 – 56 ), our data suggested that higher AMH may have little effect on oocyte quality compared to medium high AMH level or the increase in oocyte production may counteract the decrease in oocyte quality. Further clinical studies and molecular biology experiments were needed to explore the possible impact of AMH on PCO folliculogenesis and oocyte quality.…”

Section: Discussioncontrasting

confidence: 80%

“…As for the explanation of the correlation between higher AMH and poor reproductive outcome in fresh cycle in PCOS women, firstly, AMH excess in GCs from PCO would be involved in the follicle excess of PCO (54)(55)(56) and the follicular arrest in anovulatory patients (33,36), thus high AMH levels may result in the disturbed folliculogenesis of PCOS. In addition, as mentioned above, AMH levels are related to the severity of PCOS, and a positive link between AMH c oncentration and s everity of hyperandrogenemia has been found (16,32,34,57), which has a detrimental effect on oocyte quality and therefore contributes to lower fertilization rates (58).…”

Section: Discussionmentioning

confidence: 99%

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High Serum Anti-Müllerian Hormone Concentrations Are Associated With Poor Pregnancy Outcome in Fresh IVF/ICSI Cycle but Not Cumulative Live Birth Rate in PCOS Patients

Guo

Liu

et al. 2021

Front. Endocrinol.

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ObjectiveTo investigate the association between baseline serum Anti-Müllerian hormone (AMH) levels and IVF/ICSI outcomes in women with polycystic ovary syndrome (PCOS).DesignRetrospective study.SettingReproductive medicine center in a hospital.Population2436 PCOS patients (Rotterdam criteria) who underwent their first fresh IVF/ICSI cycles were divided into three groups on the basis of the <25th (Group 1, n=611), 25 to 75th (Group 2, n=1216), or >75th (Group 3, n=609) percentile of baseline serum AMH level.Intervention(s)Baseline serum AMH levels measured on the 2-3 days of spontaneous menstrual cycle before IVF/ICSI treatment.Main Outcome Measure(s)Live birth rate (LBR), cumulative live birth rate (CLBR), clinical pregnancy rate (CPR), and normal fertilization rate (FR).Result(s)The LBR, CPR, and FR were significantly increased in Group 1 than Group 2 and Group 3, however, CLBR was similar between the three groups. The LBR were 46.6%, 40.5%, and 39.4% in Group 1, Group 2, and Group 3 respectively. The CPR were 53.0%, 47.0%, and 45.5%, respectively. The FR was highest in Group 1 (61.7%, P<0.05), but there was no uniform reverse trend with the AMH level. CLBR were 68.7%, 70.4%, and 71.3%, respectively. Although women in Group 1 were older (p < 0.05) and had higher body mass index (BMI) (p < 0.05), binomial logistic regression analysis used age, BMI, FSH, and AMH as independent variables indicated that only AMH was significantly associated with LBR and CPR. Nevertheless, binomial logistic regression analysis used age, BMI, FSH, AMH, and the number of retrieved oocytes as independent variables indicated that only the number of retrieved oocytes was significantly correlated with CLBR. After stratifying by age, the negative relationship between baseline AMH level and LBR and CPR remained only in the patients <30 years old.Conclusion(s)Higher baseline AMH level in PCOS women resulted in lower LBR, CPR, and FR but did not influence CLBR.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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High Serum Anti-Müllerian Hormone Concentrations Are Associated With Poor Pregnancy Outcome in Fresh IVF/ICSI Cycle but Not Cumulative Live Birth Rate in PCOS Patients

Guo

Liu

et al. 2021

Front. Endocrinol.

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“…On the other hand, women with PCOS display increased circulating anti-müllerian hormone (AMH) that correlates with the number of antral follicles, and the AMH measurement diagnostic efficacy is superior to follicular count [15]. Besides, it seems to be a specific PCOS and reproducible marker from one menstrual cycle to another [16]. Metabolic syndrome components and indexes of insulin resistance, including homeostasis model assessment IR index (HOMA-IR), are frequently altered in patients with PCOS [10,11].…”

Section: Introductionmentioning

confidence: 99%

Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Pérez‐López

Ornat

López‐Baena

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: This systematic review and meta-analysis aimed to summarize the available evidence regarding circulating kisspeptin and anti-müllerian hormone (AMH) and the homeostasis model assessment of insulin resistance (HOMA-IR) index in adolescents and women with and without polycystic ovary syndrome (PCOS).Method: We performed a comprehensive literature search in Medline, Embase, Cochrane, Scopus, and Web of Science for studies evaluating circulating kisspeptin levels in women with and without PCOS published until September 24th, 2020. Coprimary outcomes were the HOMA-IR index and AMH. The quality of included studies was assessed using the Newcastle-Ottawa Scale. Random-effects models were used to estimate outcomes, and effects reported as mean difference (MD) or standardized MD (SMD) and their 95% confidence interval (CI). The systematic review and meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO) as number CRD42020205030. Results: We evaluated 18 studies including, 1,282 PCOS cases and 977 controls. Participants with PCOS were younger (MD=-2.38 years, 95%CI -4.32 to -0.44), with higher BMI (MD=1.16, 95% CI 0.54 to 1.78), waist-to-hip ratio (MD=0.04, 95%CI 0.02 to 0.05), circulating kisspeptin (SMD=1.15, 95%CI 0.68 to 1.62), luteinizing hormone (SMD=1.29, 95%CI 0.76 to 1.83), AMH (SMD=0.97, 95%CI 0.60 to 1,34), total testosterone (SMD=2.48, 95%CI 1.73 to 3.23), free testosterone (SMD=1.37, 95%CI 0.56 to 2.17), and dehydroepiandrosterone sulfate (SMD=0.72, 95%CI 0.32 to 1.13) levels, and Ferriman-Galweg score (SMD = 5.08, 95%CI 2.76 to 7.39), and lower sex hormone-binding globulin level (SMD=-1.34, 95%CI -2.15 to -0.52). Besides, participants with PCOS had higher HOMA-IR index (SMD=0.76, 95%CI 0.35 to 1.17), and circulating insulin (SMD=0.75, 95%CI 0.30 to 1.19), leptin (SMD=2.82, 95%CI 1.35 to 4.29), and triglycerides (SMD=2.15, 95%CI 1.08 to 3.23) levels than participants without the syndrome. The meta-regression did not identify significant factors influencing circulating kisspeptin. Conclusion:Patients with PCOS showed higher kisspeptin, LH, insulin, AMH, and androgen levels and HOMA-IR index, and lower sex hormone-binding globulin levels than those without the syndrome.

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Ovarian reserve in patients with multiple sclerosis: A systematic review and meta‐analysis

Carbone

Girolamo

Conforti

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo summarize recent evidence about ovarian reserve markers in women affected by multiple sclerosis (MS) compared with healthy controls, as women with MS seem to be characterized by lower anti‐Müllerian hormone (AMH) levels.MethodsThe research was conducted using PubMed (MEDLINE), Scopus, ClinicalTrial.gov, OVID and Cochrane Library from inception of each database to June 30, 2022. Studies comparing ovarian reserve markers between women with MS and healthy controls were considered eligible for inclusion. The primary outcome was serum AMH (ng/mL) levels. Results were reported as pooled odds ratio (OR) for categorical outcomes and as mean difference (MD) for continuous variables, with their 95% confidence intervals (CIs). The random effect model of DerSimonian and Laird was adopted for all analyses. A P‐value less than 0.05 was considered significant.ResultsSerum AMH circulating levels were not significantly different (MD −0.25, 95% CI −0.83 to 0.32; P = 0.390), as well as blood levels of follicle‐stimulating hormone or ovarian volume. However, antral follicle count (AFC) and estradiol blood levels were significantly lower, and luteinizing hormone (LH) levels were significantly higher in women with MS than in controls.ConclusionA significant difference in AFC, estradiol and LH levels was observed, but not for AMH levels.

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Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Cited by 63 publications

References 72 publications

High Serum Anti-Müllerian Hormone Concentrations Are Associated With Poor Pregnancy Outcome in Fresh IVF/ICSI Cycle but Not Cumulative Live Birth Rate in PCOS Patients

High Serum Anti-Müllerian Hormone Concentrations Are Associated With Poor Pregnancy Outcome in Fresh IVF/ICSI Cycle but Not Cumulative Live Birth Rate in PCOS Patients

Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Ovarian reserve in patients with multiple sclerosis: A systematic review and meta‐analysis

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