Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig.

Nakashima, Yoko; Sanada, Hiroo; Suzue, Ryokuero; Kawada, Shoji

doi:10.3177/jnsv.22.355

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…1986;Morita et al 1986). In addition, AA may also be required for the biosynthesis of the neurotransmitters DA (Nakashima et al 1970(Nakashima et al , 1976 and serotonin (5-HT) (Cooper 1961;Cooper and Melcer 1961;Freedland 1963;Nakashima et al 1970). In thg biosynthesis of 5-HT, AA may facilitate the conversion of tryptophan (Trp) to 5-hydroxytryptophan (5-HTrp) by Trp 5-monooxygenase (EC 1.14.16.4) by maintaining the cofactot tetrahydrofolate (THFA) in its active, reduced form (Stone and Townsley 1973;Basu and Schorah 1982).…”

Section: Introductionmentioning

confidence: 99%

Relationships between dietary ascorbic acid status and deficiency, weight gain and brain neurotransmitter levels in juvenile rainbow trout,Salmo gairdneri

Johnston

MacDonald

Hilton

1989

Fish Physiol Biochem

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A study was conducted to determine the interrelationships between dietary ascorbic acid (AA) concentrations, brain neurotransmitter levels and weight gain in juvenile rainbow trout. At the end of 4 weeks and until the end of 12 weeks of feeding test diets of varying AA concentrations (0-320 mg AA/kg diet), increased weight gain was noted in fish fed the AA-free diet. However, by the end of 13 weeks and until the end of the experiment this phenomenon was no longer evident; instead the fish showed the more classical deficiency signs of anorexia and decreased weight gain. After 12 and 24 weeks, there were no significant differences in brain serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE) or dopamine (DA) between fish reared on the different test diets. However, after 12 weeks of feeding the test diets, brain 5-HT, brain AA and weight gain were significantly correlated with one another. No such relationships were found for brain NE or brain DA. After 24 weeks of feeding the diets, the relationships between brain 5-HT, brain AA and weight gain were no longer apparent. Similarly, after 24 weeks brain NE and DA were also unrelated to brain AA and weight gain. These results provide evidence that in very young rainbow trout, AA deficiency, brain 5-HT levels and weight gain were related. However in fish reared on the diets for 24 weeks these relationships were no longer evident.

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Section: Introductionmentioning

confidence: 99%

Relationships between dietary ascorbic acid status and deficiency, weight gain and brain neurotransmitter levels in juvenile rainbow trout,Salmo gairdneri

Johnston

MacDonald

Hilton

1989

Fish Physiol Biochem

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Differential effects of transection of the spinal cord and splanchnic nerve on adrenal tyrosine hydroxylase and catecholamines

Gagner

Gauthier

1985

Neuroscience

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Effects of High Ascorbic Acid Intake on the Metabolism of Catecholamines in the Rat

Behrens¹,

Madère²

1980

The Journal of Nutrition

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The effect of high dietary ascorbic acid intake on the homeostasis of ascorbic acid and on the metabolism of catecholamine was studied in rats. In order to eliminate changes in serum levels due to stress, blood was obtained without anesthesia through implanted cannulas. Rats with a high intake of ascorbic acid (20 g/kg diet, for 7-9 weeks) had significantly higher levels of ascorbic acid in serum (83%), liver (28%), kidney (47%) and superior cervical ganglia (43%). The values were slightly, but not significantly higher in adrenal gland, brain and interscapular brown adipose tissue. However, no significant differences were observed in the levels of noradrenalin, adrenalin and dopamine in any of the tissues analyzed. Dopamine beta-hydroxylase activity was also unchanged. There was thus no evidence of an effect of high dietary intakes of ascorbic acid on the metabolism of catecholamines in the intact rat.

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Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig.

Cited by 5 publications

References 5 publications

Relationships between dietary ascorbic acid status and deficiency, weight gain and brain neurotransmitter levels in juvenile rainbow trout,Salmo gairdneri

Relationships between dietary ascorbic acid status and deficiency, weight gain and brain neurotransmitter levels in juvenile rainbow trout,Salmo gairdneri

Differential effects of transection of the spinal cord and splanchnic nerve on adrenal tyrosine hydroxylase and catecholamines

Effects of High Ascorbic Acid Intake on the Metabolism of Catecholamines in the Rat

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