Role of cerebral lateralization in control of immune processes in humans

Meador, Kimford J.; Loring, David W.; Ray, Paul H.; Helman, Sandra W.; Vázquez, Blanca; Neveu, Pierre J.

doi:10.1002/ana.20105

Cited by 57 publications

(37 citation statements)

References 25 publications

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“…Bauer et al (2009) showed that patients with well-characterized TLE led to immediate and long lasting posictal increase in systemic IL-6 levels; however this rise of IL-6 was lacking in patients with hippocampal sclerosis. The authors in accord with Meador et al,(2004) suggest the cerebral lateralization of immune functions. On the other hand, there was expression of proinflammatory molecules in neurons and glia in brain tissue obtained from patients surgically treated for drug-resistant epilepsies (Crespel et al, 2002;Maldonado et al, 2003).…”

Section: Temporal Lobe Epilepsy (Tle)supporting

confidence: 72%

Adaptive Immune Response in Epilepsy

Orozco‐Suárez¹,

Feria-Romero²,

Rayo³

et al. 2012

Recent Advances in Immunology to Target Cancer, Inflammation and Infections

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Section: Temporal Lobe Epilepsy (Tle)supporting

confidence: 72%

Adaptive Immune Response in Epilepsy

Orozco‐Suárez¹,

Feria-Romero²,

Rayo³

et al. 2012

Recent Advances in Immunology to Target Cancer, Inflammation and Infections

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“…Future studies also need to investigate why the right cerebellum, and not the left or both cerebella, was hyperactive in the malignancy cases, given known lateralization and immunity findings (20). Finally, the prognostic role of these findings should also be investigated in the future.…”

Section: Discussionmentioning

confidence: 96%

Brain Mapping of Patients with Lung Cancer and Controls: Inquiry into Tumor-to-Brain Communication: FIGURE 1.

Golan¹,

Kennedy²,

Frenkel³

et al. 2009

J Nucl Med

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Recent converging evidence suggests that the brain may receive stimuli and possibly modulate tumor progression via the vagus nerve. The present study aimed to compare brain metabolism in patients with and without lung cancer and to assess if significant differences exist in regions associated with the vagus nerve. Methods: Eighteen patients with lung malignancy and 19 controls underwent 18 F-FDG PET of the brain. Brain metabolism was compared using statistical parametric mapping. Results: Patients with lung malignancy showed a statistically significantly higher right cerebellar metabolism. Conclusion: This finding may be related to the role of the cerebellum in immune regulation, because of its proximity to the nucleus tractus solitarius innervated by the vagus and its connections with the hypothalamus. This higher metabolism in the right cerebellum may reflect an attempt to reinstate homeostasis in functions such as respiration and immunity pertinent to lung malignancy. Cancer research has shifted from solely focusing on genetic aspects and defining the intracellular etiology of tumorigenesis to also assessing interactions between tumors and their microenvironment (1). Furthermore, there is increasing interest in assessing the potential presence of bidirectional links between peripheral malignant tumors and the brain, in the form of tumor-to-brain communication and modulation (2).The inflammatory microenvironment plays a crucial role early during tumorigenesis (3,4) and later for angiogenesis and tumor invasion (5). The brain receives signals from peripheral inflammatory processes by several routes, including the vagus (6), through interleukin-1 receptors on its paraganglia. There are conflicting reports on the rate of cancer-related death in vagotomized ulcer patients (7,8). However, chemical and surgical vagotomy prevents tumorassociated anorexia in mice (9) and enhances the metastasizing rate of peripheral malignant tumors (10). In view of these studies, it has been hypothesized that the vagus (and potentially other neural routes) may provide signals about the presence of malignancy-related inflammation to the brain with possible subsequent modulation of tumorigenesis (2,11).The present study aimed to examine brain metabolism in patients with lung malignancy, addressing most of the limitations of prior studies (12-15). Most patients included in the study were evaluated because of pulmonary nodules detected on CT. Both patients and physicians were unaware of the final diagnosis with respect to the presence of active malignancy at the time of imaging, which was performed before any treatment. MATERIALS AND METHODS Patients and Control SubjectsEighteen patients with lung malignancy and 19 controls were included. The malignancy group consisted only of newly diagnosed, histologically proven cases of cancer and included 16 patients with non-small cell lung cancer ( The control group comprised a subgroup of 8 patients with lymphoma in remission for at least 4 y (the LymC group), including Hodgkin lymphoma (n 5 2, s...

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“…Likewise, women were recently reported to harbor more single cysticercotic calcified lesions in their right cerebral hemisphere than in the left. Presumably, lateralization of calcified cysticerci reflects the differential immunological abilities between the cerebral hemispheres (Meador et al, 2004). Although no sexual differences in these cerebral abilities have been notified, cysticercus lateralization is not found in male neurocysticercotic patients.…”

Section: Experimental T Solium Taeniosis/cysticercosismentioning

confidence: 96%