Role of chemoradiation in advanced cervical cancer

Singh, TB; Singh, Irungbam Deven; Sharma, Dhaneshor; Singh, Nongmaithem Romi

doi:10.4103/0019-509x.13062

Cited by 15 publications

(1 citation statement)

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“…Stress factors influence the body neurochemically, hormonally, and immunologically, and these factors have an impact on the carcinogenic process, suggesting a relationship between them and stress-induced changes in tumour growth [266]. Social stress influences tumour growth [267].…”

Section: Discussionmentioning

confidence: 99%

Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

Drochioiu

2023

Stresses

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Oncogenes are thought to play an important role in aberrant regulation of growth factors, which is believed to be an initiation event of carcinogenesis. However, recent genetic and pharmacological studies have shown that the Warburg effect (WE) is needed for tumour growth. It refers to extensively studied aerobic glycolysis over the past decade, although its impact on cancer remains unclear. Meanwhile, a large body of evidence has indicated that oxidative stress (OS) is connected with the occurrence and progression of various forms of cancer. Psychosocial factors (PSF), such as chronic depression, sadness, stressful life experiences, stress-prone personality, and emotional distress or poor quality of life affect the immune system and contribute to cancer outcomes. Here, we examine the relationship between WE, OS, PSF, metal ions, other carcinogens, and the development of different cancers from the viewpoint of physiological and biochemical mechanisms.

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Section: Discussionmentioning

confidence: 99%

Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

Drochioiu

2023

Stresses

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Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix

Green

Kirwan

Tierney

et al. 2005

Cochrane Database of Systematic Reviews

274

183

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BackgroundThe National Cancer Institute (USA) alert in February 1999 stated that concomitant chemoradiotherapy should be considered for all patients with cervical cancer, based on evidence from five randomised controlled trials (RCTs). ObjectivesTo review all known RCTs comparing concomitant chemotherapy and radiation therapy with radiotherapy for locally advanced cervical cancer. Search strategyWe searched electronic databases, trials registers and reference lists of published trial reports and review articles were also searched. Selection criteriaThis review includes RCTs in cervical cancer comparing concomitant chemoradiation with radiotherapy in the experimental arm. Trials allowing further adjuvant chemotherapy or hydroxyurea were incuded. Trials using radiosensitisers or radioprotectors in the experimental arm were excluded. Data collection and analysisTwo authors reviewed trials for inclusion and extracted data. For meta-analyses of time-to-event outcomes (survival, progression-free survival), a hazard ratio (HR) was extracted or estimated from trial reports, where possible. Only overall rates of local and distant recurrence were presented in many reports so only odds ratios (OR) of recurrence rates could be calculated, which takes no account of time to recurrence or censoring. Few trials reported acute toxicity adequately, but where possible ORs were calculated for the main types and severities of acute toxicity. The HRs and ORs for individual trials were combined across all trials, using the fixed effect model. Late toxicity was rarely described in sifficient detail so could only be reviewed qualitatively.

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Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis

2010

Cochrane Database of Systematic Reviews

135

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Role of chemoradiation in advanced cervical cancer

Cited by 15 publications

References 0 publications

Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix

Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis

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