Role of circular RNA in myocardial ischemia and ageing-related diseases

Gao, Xiaolong; Tian, Xin; Huang, Yuanhao; Fang, Rong; Wang, Gendi; Li, Dan; Zhang, Junru; Li, Tian; Yuan, Ruihua

doi:10.1016/j.cytogfr.2022.04.005

Cited by 18 publications

(7 citation statements)

References 99 publications

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“…lncRNAs can alter gene expression networks in the nucleus and modulate mRNA stability, translation, and protein function in the cytoplasm by directly interacting with RNA, DNA, or protein [ 46 , 47 ]. The regulatory actions of circular RNAs include host gene regulation, scaffold, and molecular sponge function [ 48 ]. ncRNAs can influence the cellular function of all types of cardiac cell, and are critical regulators during MI/R injury [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis

et al. 2023

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Background Numerous studies on myocardial ischemia/reperfusion (MI/R) injury have been undertaken in recent years. Hotspots and developmental trends in MI/R research are being rapidly updated. However, there has been no bibliometric analysis that systematically evaluates existing literature on MI/R injury. Our study explores developments in MI/R research over the past decade, and provides a reference for future research. Materials and methods Both experimental and clinical publications on MI/R injury from 2012 to 2021 were retrieved from the Web of Science Core Collection database. The CiteSpace and VOSviewer tools were used to perform a bibliometric analysis. Results A total of 8419 papers were analyzed. The number of annual publications demonstrated an overall upward trend, rising from 629 publications in 2012 to 1024 publications in 2021. China, the USA, Germany, England, and Italy were the top five contributors to MI/R studies. The Fourth Military Medical University in China contributed the most publications (188, 2.23%), while the University College London in England cooperated the most with relevant research institutions. Derek J Hausenloy (University College London), Derek M Yellon (University College London), and Gerd Heusch (University of Essen Medical School) were the top three most active and influential scholars according to the H-index. Among the top 10 journals with the most publications, Basic Research in Cardiology had the highest impact factors. The top three co-cited journals were Circulation, Circulation Research, and Cardiovascular Research. According to a co-cited reference analysis, MI/R research can be divided across 10 major subfields of mitophagy, cardioprotection, inflammation, remote ischemic preconditioning, long non-coding RNA, melatonin, postconditioning, mitochondria, microvascular obstruction, and ferroptosis. After 2018, the keywords with strongest citation bursts included extracellular vesicles, long non-coding RNA, cell proliferation, microRNA, mitochondrial quality control, mitophagy, biomarker, and mitochondrial biogenesis. Conclusions The present study reveals the influential authors, cooperating institutions, and main research foci in the field of MI/R injury in the past decade. The latest hotspots are a more in-depth insight into the molecular mechanisms underlying MI/R injury, such as mitochondrial quality control, non-coding RNAs, cell proliferation, and extracellular vesicles.

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Section: Discussionmentioning

confidence: 99%

Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis

et al. 2023

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“…Cell senescence refers to a permanent arrest of the cell cycle, resulting in a steady loss of the cell function to proliferate, with the continuously decreased metabolic states such as autophagy function, energy metabolism regulation and anti-stress, despite the remaining cell viability and metabolic activity [ 126 ]. Aging is accompanied by the gradually declining structural integrity of an organism [ 19 ], during which the risk of death increases [ 5 , 22 , 26 , 27 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

Wei,

Li,

Chen

et al. 2024

Cell. Mol. Life Sci.

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Fibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis is a highly orchestrated process defined by sequences of cellular response and molecular signals mechanisms underlying the disease. In pathophysiologic conditions associated with organ fibrosis, a variety of injurious stimuli such as metabolic disorders, epigenetic changes, and aging may induce the progression of fibrosis. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions. In this review, we outline our current understanding of common principles of fibrogenic mechanisms and the functional role of SIRT3/6 in aging-related fibrosis. In addition, sequences of novel protective strategies have been identified directly or indirectly according to these mechanisms. Here, we highlight the role and biological function of SIRT3/6 focus on aging fibrosis, as well as their inhibitors and activators as novel preventative or therapeutic interventions for aging-related tissue fibrosis. Graphical abstract

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“…The synthesis of circRNAs relies on reverse splicing, which includes connection between the donor site and the upstream receptor site, making circRNAs containing a single exon or multiple exons [ 4 ]. Currently, the functions of circRNAs that have been revealed mainly include “microRNAs (miRNAs) sponges”, regulation of transcription, combination with RNA binding proteins (RBPs), and encoding small peptides [ 4 – 6 ]. Moreover, circRNAs have been shown to not only serve as biomarkers to assist diagnosis in diseases such as cerebrovascular disease, various cancers, and liver disease [ 7 – 9 ], but also as therapeutic targets for these diseases [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Exploration and bioinformatic prediction for profile of mRNA bound to circular RNA BTBD7_hsa_circ_0000563 in coronary artery disease

Guo,

Zhou,

Zhang

et al. 2024

BMC Cardiovasc Disord

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Background As a novel circRNA, BTBD7_hsa_circ_0000563 has not been fully investigated in coronary artery disease (CAD). Our aim is to reveal the possible functional role and regulatory pathway of BTBD7_hsa_circ_0000563 in CAD via exploring genes combined with BTBD7_hsa_circ_0000563. Methods A total of 45 peripheral blood mononuclear cell (PBMC) samples of CAD patients were enrolled. The ChIRP-RNAseq assay was performed to directly explore genes bound to BTBD7_hsa_circ_0000563. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were conducted to reveal possible functions of these genes. The interaction network was constructed by the STRING database and the Cytoscape software. The Cytoscape software were used again to identify clusters and hub genes of genes bound to BTBD7_hsa_circ_0000563. The target miRNAs of hub genes were predicted via online databases. Results In this study, a total of 221 mRNAs directly bound to BTBD7_hsa_circ_0000563 were identified in PBMCs of CAD patients via ChIRP-RNAseq. The functional enrichment analysis revealed that these mRNAs may participate in translation and necroptosis. Moreover, the interaction network showed that there may be a close relationship between these mRNAs. Eight clusters can be further subdivided from the interaction network. RPS3 and RPSA were identified as hub genes and hsa-miR-493-5p was predicted to be the target miRNA of RPS3. Conclusions BTBD7_hsa_circ_0000563 and mRNAs directly bound to it may influence the initiation and progression of CAD, among which RPS3 and RPSA may be hub genes. These findings may provide innovative ideas for further research on CAD.

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Role of circular RNA in myocardial ischemia and ageing-related diseases

Cited by 18 publications

References 99 publications

Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis

Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

Exploration and bioinformatic prediction for profile of mRNA bound to circular RNA BTBD7_hsa_circ_0000563 in coronary artery disease

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