Role of Complement-Derived and Bacterial Formylpeptide Chemotactic Factors in the In Vivo Migration of Neutrophils in Experimental Escherichia coli Pyelonephritis in Rats

Acute pyelonephritis is a potentially life-threatening infection of the upper urinary tract. Inflammatory response and the accompanying oxidative stress can contribute to kidney tissue damage, resulting in infection-induced intoxication that can become fatal in the absence of antibiotic therapy. Here, we show that pyelonephritis was associated with oxidative stress and renal cell death. Oxidative stress observed in pyelonephritic kidney was accompanied by a reduced level of mitochondrial B-cell lymphoma 2 (Bcl-2). Importantly, renal cell death and animal mortality were both alleviated by mitochondria-targeted antioxidant 10(6′-plastoquinonyl) decylrhodamine 19 (SkQR1). These findings suggest that pyelonephritis can be treated by reducing mitochondrial reactive oxygen species and thus by protecting mitochondrial integrity and lowering kidney damage.inflammation | phenoptosis | urological diseases | innate immunity | toll-like receptors

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“…This traffic results in elevation of the levels and activities of myeloperoxidase that persists after transformation to chronic type (35).…”

Section: Discussionmentioning

confidence: 99%