Role of conventional and diffusion weighted MRI in predicting treatment response after low dose radiation and chemotherapy in locally advanced carcinoma cervix

Das, Saikat; Chandramohan, Anuradha; Reddy, Jeba Karunya Rami; Mukhopadhyay, Sabyasachi; Kumar, Rajesh; Isiah, Rajesh; John, Subhashini; Oommen, Regi; Jeyaseelan, Visalakshi

doi:10.1016/j.radonc.2015.10.006

Cited by 23 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The standard ADC value acquired by us had a higher diagnostic efficacy in predicting the response to radiochemotherapy. For example, Das et al [5] showed that the AUC of ADC in predicting the response to radiochemotherapy was 0.814, while our study showed that the AUC of standard ADC was 0.865. The possible reason is that ADC value is calculated on the basis of two b values in the study by Das et al, while the standard ADC value is calculated on the basis of 12 b-values in the study by us.…”

Section: Discussioncontrasting

confidence: 48%

“…Theoretically, DWI parameters can be acquired on the basis of different mathematical modes, such as IVIM, SEM and Gaussian diffusion models. Das et al [5] investigated the performance of Gaussian diffusion model (mono-exponential mode) of DWI in predicting the response to treatment in locally advanced cervical cancer, and found that ADC value was a good predictor for pathological response of cervical cancer. Zhu et al [6] explored the application of IVIM DWI in predicting long-term prognosis in patients with advanced cervical cancer, and found that IVIM parameters were very useful for predicting longterm prognosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The value of DWI in predicting the response to synchronous radiochemotherapy for advanced cervical carcinoma: comparison among three mathematical models

Zhang

Zhou

et al. 2020

Cancer Imaging

View full text Add to dashboard Cite

Background: Diffusion weighted imaging(DWI) mode mainly includes intravoxel incoherent motion (IVIM), stretched exponential model (SEM) and Gaussian diffusion model, but it is still unclear which mode is the most valuable in predicting the response to radiochemotherapy for cervical cancer. This study aims to compare the values of three mathematical models in predicting the response to synchronous radiochemotherapy for cervical cancer. Methods: Eighty-four patients with cervical cancer were enrolled into this study. They underwent DWI examination by using 12 b-values prior to treatment. The imaging parameters were calculated on the basis of IVIM, SEM and Gaussian diffusion models respectively. The imaging parameters derived from three mathematical modes were compared between responders and non-responders groups. The repeatability of each imaging parameter was assessed. Results: The ADC, D or DDC value was lower in responders than in non-responders groups (P = 0.03, 0.02, 0.01). The α value was higher in responders group than in non-responders group (P = 0.03). DDC had the largest area under curves (AUC) (=0.948) in predicting the response to treatment. The imaging parameters derived from SEM had better repeatability (CCC for DDC and α were 0.969 and 0.924 respectively) than that derived from other exponential models. Conclusion: Three exponential modes of DWI are useful for predicting the response to radiochemotherapy for cervical cancer, and SEM may be used as a potential optimal model for predicting treatment effect.

show abstract

Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

The value of DWI in predicting the response to synchronous radiochemotherapy for advanced cervical carcinoma: comparison among three mathematical models

Zhang

Zhou

et al. 2020

Cancer Imaging

View full text Add to dashboard Cite

show abstract

“…[ 18 F]FDG-PET is an established prognostic imaging marker in cervical cancer, and more recently diffusion-weighted MRI has also emerged as a potential imaging marker [ 3 – 8 , 10 , 12 , 26 ]. The relationship between global tumor PET and diffusion MR imaging metrics, such as SUV max and the ADC min , has previously been evaluated in cervical cancer, with data suggesting that these metrics are related [ 13 , 17 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Spatial relationship of 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography and magnetic resonance diffusion imaging metrics in cervical cancer

et al. 2018

View full text Add to dashboard Cite

BackgroundThis study investigated the spatial relationship of 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography ([18F]FDG-PET) standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) derived from magnetic resonance (MR) diffusion imaging on a voxel level using simultaneously acquired PET/MR data.We performed an institutional retrospective analysis of patients with newly diagnosed cervical cancer who received a pre-treatment simultaneously acquired [18F]FDG-PET/MR. Voxel SUV and ADC values, and global tumor metrics including maximum SUV (SUVmax), mean ADC (ADCmean), and mean tumor-to-muscle ADC ratio (ADCT/M) were compared. The impacts of histology, grade, and tumor volume on the voxel SUV to ADC relationship were also evaluated. The potential prognostic value of the voxel SUV/ADC relationship was evaluated in an exploratory analysis using Kaplan-Meier/log-rank and univariate Cox analysis.ResultsSeventeen patients with PET/MR scans were identified. There was a significant inverse correlation between SUVmax and ADCmean, and SUVmax and ADCT/M. In the voxelwise analysis, squamous cell carcinomas (SCCAs) and poorly differentiated tumors showed a consistent significant inverse correlation between voxel SUV and ADC values; adenocarcinomas (AdenoCAs) and well/moderately differentiated tumors did not. The strength of the voxel SUV/ADC correlation varied with metabolic tumor volume (MTV). On log-rank analysis, the correlation between voxel SUV/ADC values was prognostic of disease-free survival (DFS).ConclusionsIn this hypothesis-generating study, a consistent inverse correlation between voxel SUV and ADC values was seen in SCCAs and poorly differentiated tumors. On univariate statistical analysis, correlation between voxel SUV and ADC values was prognostic for DFS.Electronic supplementary materialThe online version of this article (10.1186/s13550-018-0403-7) contains supplementary material, which is available to authorized users.

show abstract

“…Very few studies have been performed to monitor changes in ADC values over time and often are performed at different time points during treatment. [14][15][16] MR-RT systems allow daily imaging during treatment, including DWI, without significant changes to the standard treatment protocol. Direct application of ADC values from dedicated MRI systems to MR-RT systems may be difficult due to substantial differences in the design of the MRI components compared to conventional diagnostic systems.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of diffusion‐weighted MRI and geometric distortion on a 0.35T MR‐LINAC at multiple gantry angles

Lewis

Guta

Mackey

et al. 2021

J Applied Clin Med Phys

View full text Add to dashboard Cite

Diffusion-weighted imaging (DWI) provides a valuable diagnostic tool for tumor evaluation. Yet, it is difficult to acquire daily MRI data sets in the traditional radiotherapy clinical setting due to patient burden and limited resources. However, integrated MRI radiotherapy treatment systems facilitate daily functional MRI acquisitions like DWI during treatment exams. Before ADC values from MR-RT systems can be used clinically their reproducibility and accuracy must be quantified. This study used a NIST traceable DWI phantom to verify ADC values acquired on a 0.35 T MR-LINAC system at multiple gantry angles. A diffusion-weighted echo planar imaging sequence was used for all image acquisitions, with b-values of 0, 500, 900, 2000 s/mm 2 for the 1.5 T and 3.0 T systems and 0, 200, 500, 800 s/mm 2 for the 0.35 T system. Images were acquired at multiple gantry angles on the MR-LINAC system from 0°to 330°in 30°increments to assess the impact of gantry angle on geometric distortion and ADC values. CT images, and three fiducial markers were used as ground truth for geometric distortion measurements. The distance between fiducial markers increased by as much as 7.2 mm on the MR-LINAC at gantry angle 60°. ADC values of deionized water vials from the 1.5 T and 3.0 T systems were 8.30 × 10-6 mm 2 /s and −0.85 × 10-6 mm 2 /s off, respectively, from the expected value of 1127 × 10-6 mm 2 /s. The MR-LINAC system provided an ADC value of the pure water vials that was −116.63 × 10-6 mm 2 /s off from the expected value of 1127 × 10-6 mm 2 /s. The MR-LINAC also showed a variation in ADC across all gantry angles of 33.72 × 10-6 mm 2 /s and 20.41 × 10-6 mm 2 /s for the vials with expected values of 1127 × 10-6 mm 2 /s and 248 × 10-6 mm 2 /s, respectively. This study showed that variation of the ADC values and geometric information on the 0.35 T MR-LINAC system was dependent on the gantry angle at acquisition.

show abstract

Role of conventional and diffusion weighted MRI in predicting treatment response after low dose radiation and chemotherapy in locally advanced carcinoma cervix

Cited by 23 publications

References 24 publications

The value of DWI in predicting the response to synchronous radiochemotherapy for advanced cervical carcinoma: comparison among three mathematical models

The value of DWI in predicting the response to synchronous radiochemotherapy for advanced cervical carcinoma: comparison among three mathematical models

Spatial relationship of 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography and magnetic resonance diffusion imaging metrics in cervical cancer

Evaluation of diffusion‐weighted MRI and geometric distortion on a 0.35T MR‐LINAC at multiple gantry angles

Contact Info

Product

Resources

About