Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function

Kinlein, Scott A.; Phillips, Derrick J.; Keller, Chandler R.; Karatsoreos, Ilia N.

doi:10.1016/j.psyneuen.2018.12.010

Cited by 80 publications

(51 citation statements)

References 47 publications

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“…The value of circulating cortisol (or CORT) has been used as a criterion of stress response in humans and various animals [115][116][117]. Corticotrophinreleasing factor facilitates aggression [118,119], and related elevation of CORT (or cortisol) also affects neuroendocrine functions through binding to their receptors [120,121], causing neuron loss in the hippocampus [122], dysfunction of the serotonergic system [123], and inhibition of immunity (increased pro-inflammatory cytokines as neuroinflammatory response) within stress-sensitive brain regions [124]. These changes finally lead to the development of psychological disorders such as aggression [109,125].…”

Section: Social Stress and The Hypothalamic-pituitary-adrenal Axismentioning

confidence: 99%

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Cheng¹,

Jiang²,

Hu³

2019

Oral Health by Using Probiotic Products

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Intestinal bacteria release various neuroactive compounds directly or indirectly regulating brain function to modulate host health and behavior through the gut-brain axis. Probiotics have been used as dietary supplements to target gut microbiota (microbiome) for prevention or therapeutic treatment of various diseases including mental disorders. In our study, chickens were used as an animal model to assess, if dietary supplementation of probiotic, Bacillus subtilis, reduces aggressive behaviors following social challenge. Chickens of an aggressive line were housed in single-hen cages. At 24 weeks of age, the hens were paired with similar body weight to identify the dominance rank (day 0). The subordinate and dominant of each pair were fed a regular layer diet or the diet mixed with 250 ppm probiotics for 2 weeks, then the second behavior test was performed between the same pair (day 14). The display of aggressive behaviors in the regular diet-fed chickens was not affected between the levels at day 0 and day 14, while the frequency of threat and aggressive pecking were reduced in the probiotic-fed chickens compared to the levels at day 0. These results suggest dietary probiotic, Bacillus subtilis, could be a suitable strategy for increasing hosts' mental health.

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Section: Social Stress and The Hypothalamic-pituitary-adrenal Axismentioning

confidence: 99%

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Cheng¹,

Jiang²,

Hu³

2019

Oral Health by Using Probiotic Products

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“…The stressors responsible for inducing transport stress syndrome are complex, including temperature, wind, rain, hunger, thirst, crowding, shock, turbulence, social interaction, feed change, physical exertion, environmental change, and invasion of pathogenic bacteria ( Delic et al, 2014 ). Corticosterone secretion and lipid mobilization are normal phenomena under stress conditions ( Chirase et al, 2004 ; Kinlein et al, 2019 ). Although TSS gradually subside through vitamin in feed, however, in some cases, a few animals do not recover by vitamins supplement, eventually decrease the production efficiency or die ( Kegley et al, 2016 ; Takemoto et al, 2017 ; Takemoto et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Characterization of Short Distance Transport Stress in Beef Cattle Blood

Zhao

Tang

et al. 2021

Front. Genet.

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The transportation is a crucial phase in beef cattle industry, and the annual losses caused by beef cattle transport stress are substantial. Several studies have described the effect of long distance transportation stress on animal health, such as disorder in nervous, endocrine, immune, and metabolic system. However, molecular mechanisms underlying short distance transportation stress is still poorly understood. Present study aims to investigate the effect of short distance transportation by measuring the hematological indices and transcriptomic analysis. In this study, a total 10 Qinchuan cattle were used to compare the molecular characteristics of blood before and after transportation. We have found that a stress-related marker “white blood cell count (WBC)” increased significantly after transportation. The decrease in triglyceride (TG), cholestenone (CHO), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) showed that energy expenditure was increased after transportation, but not enough to activate fatty decomposition. Intriguingly, the decrease of malondialdehyde (MDA) showed that cattle were more resilience to oxidative stress. The RNA-seq showed that 1,092 differentially expressed genes (DEGs) were found (329 up-regulated and 763 down-regulated) between group before and group after. The GO and KEGG enrichment showed that the metabolic pathway and B cell function related pathways were enriched. Furthermore, median absolute deviation (MAD) top 5,000 genes were used to construct a co-expression network by weighted correlation network analysis (WGCNA), and 11 independent modules were identified. Combing with protein-protein interaction (PPI) analysis, the verification of quantitative real-time PCR (qPCR) and the correlation of B cell function, structural maintenance of chromosomes 3 (SMC3), jun proto-oncogene (JUN), and C-X-C motif chemokine ligand 10 (CXCL10) were suggested as potential molecular markers in identification of short distance transportation. Collectively, the blood RNA-seq analysis and WGCNA indicated that the disorder of B cell differentiation, proliferation, survival, and apoptosis were the potential molecular mechanism in short distance transportation stress. In conclusion, our results provide the novel insight about potential biomarkers for short distance transportation stress, which may serve as for diagnosing and preventing this condition in beef industry.

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“…Multiple psychological disorders associated with PS have been reported in humans and animal models including depression, anxiety, and attention deficit hyperactivity disorder (ADHD) (Weinstock, 2001;Walsh et al, 2019;Scheinost et al, 2020), which have in common a dysregulation of the stress response system (Ramocki and Zoghbi, 2008). Glucocorticoids can influence neural circuits in the developing brain at the time of stress exposure, which can have long-term effects on brain structure, function, and plasticity (Kinlein et al, 2019). Interestingly, these effects were shown to be sexually dimorphic (Schulz et al, 2011;Iturramena et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Differences in DNA Methylation Reprogramming Underlie the Sexual Dimorphism of Behavioral Disorder Caused by Prenatal Stress in Rats

Lei

et al. 2020

Front. Neurosci.

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Prenatal stress (PS) can lead to neuroendocrine and emotional disorders later in adolescence. Sexual dimorphism in these neurodevelopmental outcomes have been observed; however, the underlying mechanisms are not fully understood. To address this issue, we investigated whether there are sex differences in epigenetic reprogramming in rats exposed to PS. Pregnant female rats were subjected to chronic restraint stress from gestational day (G)12 to G18. From postnatal day (P)38 to P45, subgroups of offspring including both males and females were subjected to behavioral testing and brain tissue specimens were analyzed by DNA pyrosequencing, western blotting, and Golgi staining to assess changes in methylation pattern of glucocorticoid receptor (GR) gene, expression of DNA methyltransferase (DNMT) and DNA demethylase, and dendrite morphology, respectively. The DNA methyltransferase inhibitor decitabine was administered to rats prior to PS to further evaluate the role of methylation in the sexually dimorphic effects of PS. The results showed that PS increased anxiety-like behavior in offspring, especially in females, while depression-like behavior was increased in male offspring compared to control littermates. The methylation pattern in the promoter region of the GR gene differed between males and females. Sex-specific changes in the expression of DNMTs (DNMT1 and DNMT3a) and DNA demethylase (Tet methylcytosine dioxygenase 2) were also observed. Interestingly, decitabine alleviated the behavioral disorder caused by PS and restored dendrite density and morphology in female but not male rats. These findings suggest that different change patterns of DNMT and demethylase in the two sexes after PS are responsible for the sexually dimorphism, which could have implications for the clinical management of stress-related disorders.

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Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function

Cited by 80 publications

References 47 publications

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Transcriptome Characterization of Short Distance Transport Stress in Beef Cattle Blood

Differences in DNA Methylation Reprogramming Underlie the Sexual Dimorphism of Behavioral Disorder Caused by Prenatal Stress in Rats

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