Role of Diffusion Weighted MRI in Intra-Axial Brain Tumours

Bhandari, Gaurav; Agrawal, Alka; Tripathi, Purva; Nischal, Neha; Goel, Vibhu

doi:10.21276/sjams.2016.4.6.49

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…The ADCs in the surrounding T2/FLAIR hyperintense in all SOL was found to be overlapping of insignificant p-value of 0.087, therefore differentiation of peritumoral edema and infiltration wasn't possible. As seen in the study by Bhandari, Desbarats and Dorenbeck [2,12,18] . There were certain limitations of this study.…”

Section: Discussionmentioning

confidence: 86%

The Role of Diffusion Weighted MRI in Differentiation of Intra-Axial Cystic Brain Lesions

Darwish¹,

Hayder

2021

The Medical Journal of Cairo University

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Background: Intracranial cystic lesions are unnatural cavities in which the continuity of the brain parenchyma is disrupted because of different pathologies such as infections and tumors containing proteinaceous fluid and/or cellular/necrotic materials. Aim of Study:The purpose of this study is to investigate the value of DWI in differentiation of the common intracranial intra-axial cystic/necrotic lesions.Patients and Methods: This is a descriptive study, conducted from July 2019 till February 2021. It is included twenty-four adult patients of either sex with a cystic/necrotic intra-axial brain lesion with variable perifocal edema and rim enhancement on post-contrast study at MRI unit, radiology department, Ain Shams University (ASU) Hospital. All examinations carried out after signing the informed consent by the patient himself or his guardian if the patient is incapacitated by any means. Results:The inflammatory lesions, the wall ADC values were not uniform. We found the lowest ADC value in contrast enhanced part of the pyogenic abscess 0.922x10 -3 mm 2 /s and the highest ADC wall value 1.529x10 -3 mm 2 /s found in toxoplasmosis abscess. There was a significant difference in the wall ADC values of metastatic lesions mean ADC of contrast enhanced part was 1.32 ±0.18x10 -3 mm 2 /s and 0.80 ±0.13x10 -3 mm 2 /s found in PCNSL, with a cut off value, sensitivity, specificity, positive predictive value (PPV) negative predictive value (NPV) and p-value of: 1.035, 100%, 100%, 100%, 100% and 0.007 respectively. The mean ADC value of the surrounding edema in our study were measured 1.40 ±0.11x10 -3 mm 2 /s for abscess group and 1.59 ±0.31x10 -3 mm 2 /s for malignant group with insignificant p-value of 0.201. Conclusion:Further more MR techniques may be used for discrimination brain abscess from cystic or necrotic tumors, as diffusion tensor imaging (DTI), MR spectroscopy and perfusion weighted imaging as well as positron emission tomography computed tomography (PET-CT) may be helpful. The use of these additional techniques will help to improve the accuracy of MR in differentiating brain abscess from cystic or necrotic tumors.

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Section: Discussionmentioning

confidence: 86%

The Role of Diffusion Weighted MRI in Differentiation of Intra-Axial Cystic Brain Lesions

Darwish¹,

Hayder

2021

The Medical Journal of Cairo University

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“…Previous studies included the adult patient group, and calculations were made from the T2-hyperintense edematous areas for the differentiation of lymphoma, metastasis and high-grade tumors (12,13,6) . In a study by Gaurav et al (12) peritumoral edema was found in 27 of 50 tumors and peritumoral infiltration could not be differentiated by ADC values. Caravan et al (6) also found that peritumoral ADC values were more significant than intratumoral ADC values among highgrade tumors and brain metastases.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to intratumoral ADC measurements, ADC values calculated from the peritumoral area, especially from the edematous area have been also used in the histopathological differentiation of brain tumors (12,13) . In all of these studies it is stated that higher ADC values in the peritumoral zone are associated with lower ADC values in the intratumoral area.…”

Section: Introductionmentioning

confidence: 99%

Do Intratumoral And Peritumoral Apparent Diffusion Coefficient (ADC) Values Have A Role In The Diagnosis Of Pediatric Brain Tumors?

Doğan¹,

Sigirci²,

Taşolar³

et al. 2020

BUCH

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INTRODUCTION: The motion of water particles within biological tissues, which is called random Brownian motion, is detected at the microscopic level by Diffusion-Weighted Imaging (DWI) sequence of Magnetic Resonance Image technique. The Apparent Diffusion Coefficient (ADC) calculated on DWI has been used for tumor diagnosis and grading. The purpose of this study was to evaluate of ADC values in the differential diagnosis of supratentorial and infratentorial pediatric brain tumors and to reveal the difference of peritumoral ADC measurements of pediatric patients from adult patients. METHODS: All of the 56 pediatric patients included in this retrospective study had lesions >1 cm in diameter on magnetic resonance image and all of the diagnosies were confirmed by histopathology. Intratumoral and peritumoral ADC values and ratios were measured in diffusion weighted Magnetic Resonance Image. RESULTS: The 58.9% (n=33) of these tumors were supratentorial and 41.1% (n=23) were infratentorial. ADC values and ADC ratios were significantly lower in high-grade tumors than low-grade tumors (p<0.05). Peritumoral ADC values in high-grade tumors were lower than low grade tumors (p<0.05). The cut-off value of the ADC ratio between these two groups was 1 and the ADC cut-off value was 1.1*10-3 mm2/s. DISCUSSION AND CONCLUSION: In the differentiation of low and high-grade pediatric brain tumors, cut-off values of 1.1*10_3mm2/s for ADC Value and 1.0 for ADC Ratio may be useful. Although, peritumoral ADC values differ in children compared to the adult group, both intratumoral and peritumoral ADC values can help for grading pediatric brain tumors.

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Role of Diffusion Weighted MRI in Intra-Axial Brain Tumours

Cited by 2 publications

References 15 publications

The Role of Diffusion Weighted MRI in Differentiation of Intra-Axial Cystic Brain Lesions

The Role of Diffusion Weighted MRI in Differentiation of Intra-Axial Cystic Brain Lesions

Do Intratumoral And Peritumoral Apparent Diffusion Coefficient (ADC) Values Have A Role In The Diagnosis Of Pediatric Brain Tumors?

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